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Title: Preparation of 4-amino-2,4-dioxobutanoic acid

A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl 2-cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1243346
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM) New Mexico Highlands University (Las Vegas, NM) LANL
Patent Number(s):
9,290,442
Application Number:
14/486,423
Contract Number:
AC52-06NA25396
Resource Relation:
Patent File Date: 2014 Sep 15
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

Synthese von 1.5-Diaza-cyclooctan-dion-(4.8)-dicarbonsäure-(2.6)
journal, April 1954
  • Weygand, Friedrich; Dietrich, Heinz-Jürgen
  • Chemische Berichte, Vol. 87, Issue 4, p. 482-488
  • DOI: 10.1002/cber.19540870408

Biological functions of proline in morphogenesis and osmotolerance revealed in antisense transgenic Arabidopsis thaliana
journal, April 1999