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Title: Protein scaffolds for selective enrichment of metal ions

Polypeptides comprising high affinity for the uranyl ion are provided. Methods for binding uranyl using such proteins are likewise provided and can be used, for example, in methods for uranium purification or removal.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1241347
Assignee:
The University of Chicago (Chicago, IL) CHO
Patent Number(s):
9,255,019
Application Number:
14/394,024
Contract Number:
FG02-07ER15865
Resource Relation:
Patent File Date: 2013 Mar 13
Research Org:
The University of Chicago, Chicago, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Other works cited in this record:

Characterization of a helical protein designed from first principles
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Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils
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  • Touw, D. S.; Nordman, C. E.; Stuckey, J. A.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 29, p. 11969-11974
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Expanding the utility of proteins as platforms for coordination chemistry
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  • Coordination Chemistry Reviews, Vol. 255, Issue 7-8, p. 790-803
  • DOI: 10.1016/j.ccr.2010.10.010

Stereognostic coordination chemistry. 1. The design and synthesis of chelators for the uranyl ion
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Engineering A Uranyl-Specific Binding Protein from NikR
journal, February 2009
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  • Angewandte Chemie International Edition, Vol. 48, Issue 13, p. 2339-2341
  • DOI: 10.1002/anie.200805262

Interactions of uranium and thorium with arsenazo III in an aqueous medium
journal, April 1997

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