Protein scaffolds for selective enrichment of metal ions

He, Chuan; Zhou, Lu; Bosscher, Michael

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Title: Protein scaffolds for selective enrichment of metal ions

Abstract

Polypeptides comprising high affinity for the uranyl ion are provided. Methods for binding uranyl using such proteins are likewise provided and can be used, for example, in methods for uranium purification or removal.

Inventors:: He, Chuan; Zhou, Lu; Bosscher, Michael

Issue Date:: Tue Feb 09 00:00:00 EST 2016

Research Org.:: The University of Chicago, Chicago, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1241347

Patent Number(s):: 9255019

Application Number:: 14/394,024

Assignee:: The University of Chicago (Chicago, IL)

Patent Classifications (CPCs):: C - CHEMISTRY C02 - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE C02F - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

Show more

C - CHEMISTRY C02 - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE C02F - TREATMENT OF WATER, WASTE WATER, SEWAGE, OR SLUDGE
C02F1/683 - {by addition of complex-forming compounds}
C02F2101/20 - Heavy metals or heavy metal compounds
C02F2303/18 - Removal of treatment agents after treatment
C02F2305/00 - Use of specific compounds during water treatment

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/00 - Peptides having more than 20 amino acids
C07K14/47 - from mammals

Show less

DOE Contract Number:: FG02-07ER15865

Resource Type:: Patent

Resource Relation:: Patent File Date: 2013 Mar 13

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    He, Chuan, Zhou, Lu, and Bosscher, Michael. Protein scaffolds for selective enrichment of metal ions.  United States: N. p., 2016. 
        Web.

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                    He, Chuan, Zhou, Lu, & Bosscher, Michael. Protein scaffolds for selective enrichment of metal ions.  United States.

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                    He, Chuan, Zhou, Lu, and Bosscher, Michael. Tue .  
        "Protein scaffolds for selective enrichment of metal ions".  United States.  https://www.osti.gov/servlets/purl/1241347.

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@article{osti_1241347,

  title        = {Protein scaffolds for selective enrichment of metal ions},

  author       = {He, Chuan and Zhou, Lu and Bosscher, Michael},

  abstractNote = {Polypeptides comprising high affinity for the uranyl ion are provided. Methods for binding uranyl using such proteins are likewise provided and can be used, for example, in methods for uranium purification or removal.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Feb 09 00:00:00 EST 2016},

  month        = {Tue Feb 09 00:00:00 EST 2016}

}

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Site-Selective Metal Binding by Designed α-Helical Peptides
journal, December 2005

Matzapetakis, Manolis; Pecoraro, Vincent L.
Journal of the American Chemical Society, Vol. 127, Issue 51
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Expanding the utility of proteins as platforms for coordination chemistry
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Similar Records

Title: Protein scaffolds for selective enrichment of metal ions

Abstract

Citation Formats

Affinity gradients drive copper to cellular destinations journal, May 2010

Characterization of a helical protein designed from first principles journal, August 1988

Crystal structure of a synthetic triple-stranded alpha-helical bundle journal, February 1993

Assessing the Integrity of Designed Homomeric Parallel Three-Stranded Coiled Coils in the Presence of Metal Ions journal, December 2006

Kinetics of Folding of Leucine Zipper Domains journal, March 1995

Artificial Metalloenzymes: Combining the Best Features of Homogeneous and Enzymatic Catalysis journal, October 2009

De Novo Design and Structural Characterization of Proteins and Metalloproteins journal, June 1999

Engineering enzymes journal, January 2011

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold journal, October 2011

Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils journal, July 2007

Site-Selective Metal Binding by Designed α-Helical Peptides journal, December 2005

Expanding the utility of proteins as platforms for coordination chemistry journal, April 2011

Design of functional metalloproteins journal, August 2009

Stereognostic coordination chemistry. 1. The design and synthesis of chelators for the uranyl ion journal, October 1992

Rational Design of Sequestering Agents for Plutonium and Other Actinides journal, November 2003

Engineering A Uranyl-Specific Binding Protein from NikR journal, February 2009

Highly Sensitive and Selective Colorimetric Sensors for Uranyl (UO 2 2+ ): Development and Comparison of Labeled and Label-Free DNAzyme-Gold Nanoparticle Systems journal, October 2008

Selective binding of uranyl cation by a novel calmodulin peptide journal, January 2006

Interactions of uranium and thorium with arsenazo III in an aqueous medium journal, April 1997

Display of β-lactamase on the Escherichia coli surface: outer membrane phenotypes conferred by Lpp′–OmpA′–β-lactamase fusions journal, January 1996

Chemical Forms of Uranium in Artificial Seawater journal, February 1982

Rational Design of Sequestering Agents for Plutonium and Other Actinides journal, November 2003

Affinity gradients drive copper to cellular destinations
journal, May 2010

Characterization of a helical protein designed from first principles
journal, August 1988

Crystal structure of a synthetic triple-stranded alpha-helical bundle
journal, February 1993

Assessing the Integrity of Designed Homomeric Parallel Three-Stranded Coiled Coils in the Presence of Metal Ions
journal, December 2006

Kinetics of Folding of Leucine Zipper Domains
journal, March 1995

Artificial Metalloenzymes: Combining the Best Features of Homogeneous and Enzymatic Catalysis
journal, October 2009

De Novo Design and Structural Characterization of Proteins and Metalloproteins
journal, June 1999

Engineering enzymes
journal, January 2011

Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
journal, October 2011

Identifying important structural characteristics of arsenic resistance proteins by using designed three-stranded coiled coils
journal, July 2007

Site-Selective Metal Binding by Designed α-Helical Peptides
journal, December 2005

Expanding the utility of proteins as platforms for coordination chemistry
journal, April 2011

Design of functional metalloproteins
journal, August 2009

Stereognostic coordination chemistry. 1. The design and synthesis of chelators for the uranyl ion
journal, October 1992

Rational Design of Sequestering Agents for Plutonium and Other Actinides
journal, November 2003

Engineering A Uranyl-Specific Binding Protein from NikR
journal, February 2009

Highly Sensitive and Selective Colorimetric Sensors for Uranyl (UO ₂ ²⁺ ): Development and Comparison of Labeled and Label-Free DNAzyme-Gold Nanoparticle Systems
journal, October 2008

Selective binding of uranyl cation by a novel calmodulin peptide
journal, January 2006

Interactions of uranium and thorium with arsenazo III in an aqueous medium
journal, April 1997

Display of β-lactamase on the Escherichia coli surface: outer membrane phenotypes conferred by Lpp′–OmpA′–β-lactamase fusions
journal, January 1996

Chemical Forms of Uranium in Artificial Seawater
journal, February 1982

Rational Design of Sequestering Agents for Plutonium and Other Actinides
journal, November 2003