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Title: Keto-isovalerate decarboxylase enzymes and methods of use thereof

Provided herein are polypeptides and polynucleotides encoding such polypeptides which have ketoisovalerate decarboxylase activity. Also provided are recombinant host cells comprising such polypeptides and polynucleotides and methods of use thereof.
Inventors:
; ; ; ; ;
Issue Date:
OSTI Identifier:
1236558
Assignee:
Butamax Advanced Biofuels LLC ARPA-E
Patent Number(s):
9,238,828
Application Number:
13/560,147
Contract Number:
AR0000006
Resource Relation:
Patent File Date: 2012 Jul 27
Research Org:
Butamax Advanced Biofuels LLC, Wilmington, DE (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

Branched-Chain Keto Acid Decarboxylase from Lactococcus lactis (KdcA), a Valuable Thiamine Diphosphate-Dependent Enzyme for Asymmetric C-C Bond Formation
journal, June 2007
  • Gocke, Dörte; Nguyen, Cong Luan; Pohl, Martina
  • Advanced Synthesis & Catalysis, Vol. 349, Issue 8-9, p. 1425-1435
  • DOI: 10.1002/adsc.200700057

Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction
journal, November 2007
  • Berthold, Catrine L.; Gocke, Dörte; Wood, Martin D.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 63, Issue 12, p. 1217-1224
  • DOI: 10.1107/S0907444907050433

The role of induced fit and conformational changes of enzymes in specificity and catalysis
journal, March 1988

Determinants of substrate specificity in KdcA, a thiamin diphosphate-dependent decarboxylase
journal, December 2006
  • Yep, Alejandra; Kenyon, George L.; McLeish, Michael J.
  • Bioorganic Chemistry, Vol. 34, Issue 6, p. 325-336
  • DOI: 10.1016/j.bioorg.2006.08.005

Alcohol dehydrogenases (ADH) useful for fermentive production of lower alkyl alcohols
patent, July 2014

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