skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Keto-isovalerate decarboxylase enzymes and methods of use thereof

Abstract

Provided herein are polypeptides and polynucleotides encoding such polypeptides which have ketoisovalerate decarboxylase activity. Also provided are recombinant host cells comprising such polypeptides and polynucleotides and methods of use thereof.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Butamax Advanced Biofuels LLC, Wilmington, DE (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1236558
Patent Number(s):
9238828
Application Number:
13/560,147
Assignee:
Butamax Advanced Biofuels LLC
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AR0000006
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Jul 27
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES

Citation Formats

McElvain, Jessica, O'Keefe, Daniel P., Paul, Brian James, Payne, Mark S., Rothman, Steven Cary, and He, Hongxian. Keto-isovalerate decarboxylase enzymes and methods of use thereof. United States: N. p., 2016. Web.
McElvain, Jessica, O'Keefe, Daniel P., Paul, Brian James, Payne, Mark S., Rothman, Steven Cary, & He, Hongxian. Keto-isovalerate decarboxylase enzymes and methods of use thereof. United States.
McElvain, Jessica, O'Keefe, Daniel P., Paul, Brian James, Payne, Mark S., Rothman, Steven Cary, and He, Hongxian. Tue . "Keto-isovalerate decarboxylase enzymes and methods of use thereof". United States. https://www.osti.gov/servlets/purl/1236558.
@article{osti_1236558,
title = {Keto-isovalerate decarboxylase enzymes and methods of use thereof},
author = {McElvain, Jessica and O'Keefe, Daniel P. and Paul, Brian James and Payne, Mark S. and Rothman, Steven Cary and He, Hongxian},
abstractNote = {Provided herein are polypeptides and polynucleotides encoding such polypeptides which have ketoisovalerate decarboxylase activity. Also provided are recombinant host cells comprising such polypeptides and polynucleotides and methods of use thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {1}
}

Patent:

Save / Share:

Works referenced in this record:

Use of the valine biosynthetic pathway to convert glucose into isobutanol
journal, December 2010


Branched-Chain Keto Acid Decarboxylase from Lactococcus lactis (KdcA), a Valuable Thiamine Diphosphate-Dependent Enzyme for Asymmetric C-C Bond Formation
journal, June 2007


Application of α-keto acid decarboxylases in biotransformations
journal, June 1998


Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes
journal, July 2009


Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction
journal, November 2007


Aspartate-27 and glutamate-473 are involved in catalysis by Zymomonas mobilis pyruvate decarboxylase
journal, April 1999


The role of induced fit and conformational changes of enzymes in specificity and catalysis
journal, March 1988


Identification, Cloning, and Characterization of a Lactococcus lactis Branched-Chain  -Keto Acid Decarboxylase Involved in Flavor Formation
journal, January 2005


Determinants of substrate specificity in KdcA, a thiamin diphosphate-dependent decarboxylase
journal, December 2006