Keto-isovalerate decarboxylase enzymes and methods of use thereof
Abstract
Provided herein are polypeptides and polynucleotides encoding such polypeptides which have ketoisovalerate decarboxylase activity. Also provided are recombinant host cells comprising such polypeptides and polynucleotides and methods of use thereof.
- Inventors:
- Issue Date:
- Research Org.:
- Butamax Advanced Biofuels LLC, Wilmington, DE (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1236558
- Patent Number(s):
- 9238828
- Application Number:
- 13/560,147
- Assignee:
- Butamax Advanced Biofuels LLC
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
- DOE Contract Number:
- AR0000006
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Jul 27
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES
Citation Formats
McElvain, Jessica, O'Keefe, Daniel P., Paul, Brian James, Payne, Mark S., Rothman, Steven Cary, and He, Hongxian. Keto-isovalerate decarboxylase enzymes and methods of use thereof. United States: N. p., 2016.
Web.
McElvain, Jessica, O'Keefe, Daniel P., Paul, Brian James, Payne, Mark S., Rothman, Steven Cary, & He, Hongxian. Keto-isovalerate decarboxylase enzymes and methods of use thereof. United States.
McElvain, Jessica, O'Keefe, Daniel P., Paul, Brian James, Payne, Mark S., Rothman, Steven Cary, and He, Hongxian. Tue .
"Keto-isovalerate decarboxylase enzymes and methods of use thereof". United States. https://www.osti.gov/servlets/purl/1236558.
@article{osti_1236558,
title = {Keto-isovalerate decarboxylase enzymes and methods of use thereof},
author = {McElvain, Jessica and O'Keefe, Daniel P. and Paul, Brian James and Payne, Mark S. and Rothman, Steven Cary and He, Hongxian},
abstractNote = {Provided herein are polypeptides and polynucleotides encoding such polypeptides which have ketoisovalerate decarboxylase activity. Also provided are recombinant host cells comprising such polypeptides and polynucleotides and methods of use thereof.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2016},
month = {1}
}
Works referenced in this record:
Use of the valine biosynthetic pathway to convert glucose into isobutanol
journal, December 2010
- Savrasova, Ekaterina A.; Kivero, Aleksander D.; Shakulov, Rustem S.
- Journal of Industrial Microbiology & Biotechnology, Vol. 38, Issue 9
Biochemical and molecular characterization of α-ketoisovalerate decarboxylase, an enzyme involved in the formation of aldehydes from amino acids by Lactococcus lactis
journal, September 2004
- Plaza, Marta; Fernández de Palencia, Pilar; Peláez, Carmen
- FEMS Microbiology Letters, Vol. 238, Issue 2
Branched-Chain Keto Acid Decarboxylase from Lactococcus lactis (KdcA), a Valuable Thiamine Diphosphate-Dependent Enzyme for Asymmetric C-C Bond Formation
journal, June 2007
- Gocke, Dörte; Nguyen, Cong Luan; Pohl, Martina
- Advanced Synthesis & Catalysis, Vol. 349, Issue 8-9, p. 1425-1435
Application of α-keto acid decarboxylases in biotransformations
journal, June 1998
- Iding, H.; Siegert, P.; Mesch, K.
- Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, Vol. 1385, Issue 2
Engineering the isobutanol biosynthetic pathway in Escherichia coli by comparison of three aldehyde reductase/alcohol dehydrogenase genes
journal, July 2009
- Atsumi, Shota; Wu, Tung-Yun; Eckl, Eva-Maria
- Applied Microbiology and Biotechnology, Vol. 85, Issue 3
Structure of the branched-chain keto acid decarboxylase (KdcA) from Lactococcus lactis provides insights into the structural basis for the chemoselective and enantioselective carboligation reaction
journal, November 2007
- Berthold, Catrine L.; Gocke, Dörte; Wood, Martin D.
- Acta Crystallographica Section D Biological Crystallography, Vol. 63, Issue 12, p. 1217-1224
Aspartate-27 and glutamate-473 are involved in catalysis by Zymomonas mobilis pyruvate decarboxylase
journal, April 1999
- Chang, Alan K.; Nixon, Peter F.; Duggleby, Ronald G.
- Biochemical Journal, Vol. 339, Issue 2
The role of induced fit and conformational changes of enzymes in specificity and catalysis
journal, March 1988
- Herschlag, Daniel
- Bioorganic Chemistry, Vol. 16, Issue 1, p. 62-96
Identification, Cloning, and Characterization of a Lactococcus lactis Branched-Chain -Keto Acid Decarboxylase Involved in Flavor Formation
journal, January 2005
- Smit, B. A.; van Hylckama Vlieg, J. E. T.; Engels, W. J. M.
- Applied and Environmental Microbiology, Vol. 71, Issue 1
Determinants of substrate specificity in KdcA, a thiamin diphosphate-dependent decarboxylase
journal, December 2006
- Yep, Alejandra; Kenyon, George L.; McLeish, Michael J.
- Bioorganic Chemistry, Vol. 34, Issue 6, p. 325-336
Alcohol dehydrogenases (ADH) useful for fermentive production of lower alkyl alcohols
patent, July 2014
- Satagopan, Sriram; O'Keefe, Daniel; Gude, Janardhan
- US Patent Document 8,765,433