Polymer scaffold degradation control via chemical control
Abstract
A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.
- Inventors:
- Issue Date:
- Research Org.:
- Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1234693
- Patent Number(s):
- 9228042
- Application Number:
- 14/147,983
- Assignee:
- STC.UNM (Albuquerque, NM)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08G - MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- DOE Contract Number:
- AC04-94AL85000
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Jan 06
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
Citation Formats
Hedberg-Dirk, Elizabeth L., Dirk, Shawn, and Cicotte, Kirsten. Polymer scaffold degradation control via chemical control. United States: N. p., 2016.
Web.
Hedberg-Dirk, Elizabeth L., Dirk, Shawn, & Cicotte, Kirsten. Polymer scaffold degradation control via chemical control. United States.
Hedberg-Dirk, Elizabeth L., Dirk, Shawn, and Cicotte, Kirsten. Tue .
"Polymer scaffold degradation control via chemical control". United States. https://www.osti.gov/servlets/purl/1234693.
@article{osti_1234693,
title = {Polymer scaffold degradation control via chemical control},
author = {Hedberg-Dirk, Elizabeth L. and Dirk, Shawn and Cicotte, Kirsten},
abstractNote = {A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Jan 05 00:00:00 EST 2016},
month = {Tue Jan 05 00:00:00 EST 2016}
}
Works referenced in this record:
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Investigation of Maleate-Fumarate Isomerization in Unsaturated Polyesters by Nuclear Magnetic Resonance
journal, September 1964
- Curtis, L. G.; Edwards, D. L.; Simons, R. M.
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Non cross-linked block polyetherester, preparation and uses
patent, December 2003
- Ferruti, Paolo; Orsolini, Piero
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