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Title: Polymer scaffold degradation control via chemical control

A variety of polymers and copolymers suitable for use as biologically compatible constructs and, as a non-limiting specific example, in the formation of degradable tissue scaffolds as well methods for synthesizing these polymers and copolymers are described. The polymers and copolymers have degradation rates that are substantially faster than those of previously described polymers suitable for the same uses. Copolymers having a synthesis route which enables one to fine tune the degradation rate by selecting the specific stoichiometry of the monomers in the resulting copolymer are also described. The disclosure also provides a novel synthesis route for maleoyl chloride which yields monomers suitable for use in the copolymer synthesis methods described herein.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1234693
Assignee:
STC.UNM (Albuquerque, NM) SNL-A
Patent Number(s):
9,228,042
Application Number:
14/147,983
Contract Number:
AC04-94AL85000
Resource Relation:
Patent File Date: 2014 Jan 06
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

N.m.r. study of maleate (cis)—fumarate (trans) isomerism in unsaturated polyesters and related compounds
journal, January 1995

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