skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method for the electro-addressable functionalization of electrode arrays

Abstract

A method for preparing an electrochemical biosensor uses bias-assisted assembly of unreactive -onium molecules on an electrode array followed by post-assembly electro-addressable conversion of the unreactive group to a chemical or biological recognition group. Electro-addressable functionalization of electrode arrays enables the multi-target electrochemical sensing of biological and chemical analytes.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1229736
Patent Number(s):
9212430
Application Number:
11/930,267
Assignee:
Sandia Corporation
Patent Classifications (CPCs):
C - CHEMISTRY C40 - COMBINATORIAL TECHNOLOGY C40B - COMBINATORIAL CHEMISTRY
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07C - ACYCLIC OR CARBOCYCLIC COMPOUNDS
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2007 Oct 31
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING

Citation Formats

Harper, Jason C., Polsky, Ronen, Dirk, Shawn M., Wheeler, David R., Arango, Dulce C., and Brozik, Susan M. Method for the electro-addressable functionalization of electrode arrays. United States: N. p., 2015. Web.
Harper, Jason C., Polsky, Ronen, Dirk, Shawn M., Wheeler, David R., Arango, Dulce C., & Brozik, Susan M. Method for the electro-addressable functionalization of electrode arrays. United States.
Harper, Jason C., Polsky, Ronen, Dirk, Shawn M., Wheeler, David R., Arango, Dulce C., and Brozik, Susan M. Tue . "Method for the electro-addressable functionalization of electrode arrays". United States. https://www.osti.gov/servlets/purl/1229736.
@article{osti_1229736,
title = {Method for the electro-addressable functionalization of electrode arrays},
author = {Harper, Jason C. and Polsky, Ronen and Dirk, Shawn M. and Wheeler, David R. and Arango, Dulce C. and Brozik, Susan M.},
abstractNote = {A method for preparing an electrochemical biosensor uses bias-assisted assembly of unreactive -onium molecules on an electrode array followed by post-assembly electro-addressable conversion of the unreactive group to a chemical or biological recognition group. Electro-addressable functionalization of electrode arrays enables the multi-target electrochemical sensing of biological and chemical analytes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {12}
}

Patent:

Save / Share:

Works referenced in this record:

Immobilization of glucose oxidase on a carbon surface derivatized by electrochemical reduction of diazonium salts
journal, September 1992


Covalent modification of carbon surfaces by grafting of functionalized aryl radicals produced from electrochemical reduction of diazonium salts
journal, July 1992


Biotinylation of Screen-Printed Carbon Electrodes through the Electrochemical Reduction of the Diazonium Salt of p -Aminobenzoyl Biocytin
journal, July 1999


Electrically Addressable Biomolecular Functionalization of Carbon Nanotube and Carbon Nanofiber Electrodes
journal, September 2004


Diazonium salts: Stable monolayers on gold electrodes for sensing applications
journal, February 2007


Protein Pattern Assembly by Active Control of a Triblock Copolymer Monolayer
journal, December 2006


DNA immobilization onto electrochemically functionalized Si(100) surfaces
journal, October 2006


Direct Covalent Grafting of Conjugated Molecules onto Si, GaAs, and Pd Surfaces from Aryldiazonium Salts
journal, January 2004

  • Stewart, Michael P.; Maya, Francisco; Kosynkin, Dmitry V.
  • Journal of the American Chemical Society, Vol. 126, Issue 1, p. 370-378
  • https://doi.org/10.1021/ja0383120

Formation of Polyphenylene Films on Metal Electrodes by Electrochemical Reduction of Benzenediazonium Salts
journal, April 2006


Covalent Modification of Carbon Surfaces by Aryl Radicals Generated from the Electrochemical Reduction of Diazonium Salts
journal, January 1997


Phenyl layers on H–Si(111) by electrochemical reduction of diazonium salts: monolayer versus multilayer formation
journal, July 2003


Mono- and Multilayer Formation by Diazonium Reduction on Carbon Surfaces Monitored with Atomic Force Microscopy “Scratching”
journal, August 2003


Organic Layers Bonded to Industrial, Coinage, and Noble Metals through Electrochemical Reduction of Aryldiazonium Salts
journal, September 2003


Square wave voltammetric detection of 2,4,6-trinitrotoluene and 2,4-dinitrotoluene on a gold electrode modified with self-assembled monolayers
journal, August 2008


Multilayer Nitroazobenzene Films Covalently Attached to Carbon. An AFM and Electrochemical Study
journal, May 2005


Nanoscale Patterning of Flat Carbon Surfaces by Scanning Probe Lithography and Electrochemistry
journal, March 2005


Parallel dip-pen nanolithography with arrays of individually addressable cantilevers
journal, February 2004


Organometallic Chemistry on Silicon and Germanium Surfaces
journal, May 2002


Diazonium−Protein Adducts for Graphite Electrode Microarrays Modification:  Direct and Addressed Electrochemical Immobilization
journal, December 2005


Direct electrochemical addressing of immunoglobulins: Immuno-chip on screen-printed microarray
journal, February 2007


Electrochemical Attachment of Organic Groups to Carbon Felt Surfaces
journal, October 2001


Potential-Directed Assembly of Aryl Iodonium Salts onto Silicon {100} Hydride Terminated and Platinum Surfaces
journal, November 2005


Microscale Patterning of Organic Films on Carbon Surfaces Using Electrochemistry and Soft Lithography
journal, December 2006


A parallel microfluidic channel fixture fabricated using laser ablated plastic laminates for electrochemical and chemiluminescent biodetection of DNA
journal, December 2011


Carbon Electrodes Modified with TiO2/Metal Nanoparticles and Their Application for the Detection of Trinitrotoluene
journal, June 2007


Electrografting of Poly(ethylene glycol) Acrylate: A One-Step Strategy for the Synthesis of Protein-Repellent Surfaces
journal, August 2005


The Evolution of Dip-Pen Nanolithography
journal, January 2004


A Multifunctional Thin Film Au Electrode Surface Formed by Consecutive Electrochemical Reduction of Aryl Diazonium Salts
journal, March 2009


Maleimide-Activated Aryl Diazonium Salts for Electrode Surface Functionalization with Biological and Redox-Active Molecules
journal, March 2008


Electrochemical Detectors Prepared by Electroless Deposition for Microfabricated Electrophoresis Chips
journal, October 2000


Metallic Nanoparticle−Carbon Nanotube Composites for Electrochemical Determination of Explosive Nitroaromatic Compounds
journal, August 2006


Covalent Bonding of Organic Molecules to Cu and Al Alloy 2024 T3 Surfaces via Diazonium Ion Reduction
journal, January 2004


Nanopatterning of Alkynes on Hydrogen-Terminated Silicon Surfaces by Scanning Probe-Induced Cathodic Electrografting
journal, September 2003


Formation of Multilayers on Glassy Carbon Electrodes via the Reduction of Diazonium Salts
journal, September 2001


Direct electrochemistry of horseradish peroxidase bonded on a conducting polymer modified glassy carbon electrode
journal, November 2003


Scanning Probe Lithography Using Self-Assembled Monolayers
journal, November 2003


Electrochemical AFM “Dip-Pen” Nanolithography
journal, March 2001


Electrografting of Preformed Aliphatic Polyesters onto Metallic Surfaces
journal, April 2002


The Electrochemical Grafting of a Mixture of Substituted Phenyl Groups at a Glassy Carbon Electrode Surface
journal, June 2008


Simultaneous determination of nitrobenzene and nitro-substituted phenols by differential pulse voltammetry and chemometrics
journal, March 2001


Functionalization of Multi-Walled Carbon Nanotubes by Electrografting of Polyacrylonitrile
journal, May 2004


Attachment of organic layers to conductive or semiconductive surfaces by reduction of diazonium salts
journal, January 2005


Electrically Addressable Cell Immobilization Using Phenylboronic Acid Diazonium Salts
journal, March 2008


Electrically addressable diazonium-functionalized antibodies for multianalyte electrochemical sensor applications
journal, January 2008


Multifunctional Electrode Arrays: Towards a Universal Detection Platform
journal, March 2008


Nucleic Acid-Functionalized Pt Nanoparticles:  Catalytic Labels for the Amplified Electrochemical Detection of Biomolecules
journal, April 2006


Reagentless electrochemical immunoassay using electrocatalytic nanoparticle-modified antibodies
journal, January 2007


Enzyme Based Amperometric Biosensors for Food Analysis
journal, February 2002


Anti-Sticking Effect of Organic Dielectric Formed by Electrodeposition in Microelectromechanical-System Structures
journal, July 2005


Sensors—An effective approach for the detection of explosives
journal, June 2007


Modified Carbon Surfaces as “Organic Electrodes” That Exhibit Conductance Switching
journal, January 2003


Covalent Grafting of Glassy Carbon Electrodes with Diaryliodonium Salts:  New Aspects
journal, March 2007


Carbon nanotube-modified glassy carbon electrode for adsorptive stripping voltammetric detection of ultratrace levels of 2,4,6-trinitrotoluene
journal, February 2004


Electrochemical Sensing of Explosives
journal, February 2007


On-line electrochemical monitoring of (TNT) 2,4,6-trinitrotoluene in natural waters
journal, June 2003


Real-Time Electrochemical Monitoring:  Toward Green Analytical Chemistry
journal, September 2002


Screen-printed voltammetric sensor for TNT
journal, August 1998


Single-Channel Microchip for Fast Screening and Detailed Identification of Nitroaromatic Explosives or Organophosphate Nerve Agents
journal, March 2002


Surface Functionalization of Ultrananocrystalline Diamond Films by Electrochemical Reduction of Aryldiazonium Salts
journal, December 2004


Functionalized carbon nanotubes as sensitive materials for electrochemical detection of ultra-trace 2,4,6-trinitrotoluene
journal, January 2006