Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control

Title: Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control

Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.

Inventors:: Cary, Robert E.

Issue Date:: 2015-12-08

OSTI Identifier:: 1228041

Assignee:: Los Alamos National Security, LLC LANL

Patent Number(s):: 9,207,236

Application Number:: 12/940,973

Contract Number:: AC52-06NA25396

Resource Relation:: Patent File Date: 2010 Nov 05

Research Org:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

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