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Title: Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control

Highly simplified lateral flow chromatographic nucleic acid sample preparation methods, devices, and integrated systems are provided for the efficient concentration of trace samples and the removal of nucleic acid amplification inhibitors. Methods for capturing and reducing inhibitors of nucleic acid amplification reactions, such as humic acid, using polyvinylpyrrolidone treated elements of the lateral flow device are also provided. Further provided are passive fluid control methods and systems for use in lateral flow assays.
Inventors:
Issue Date:
OSTI Identifier:
1228041
Assignee:
Los Alamos National Security, LLC LANL
Patent Number(s):
9,207,236
Application Number:
12/940,973
Contract Number:
AC52-06NA25396
Resource Relation:
Patent File Date: 2010 Nov 05
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

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