Host cells and methods for producing isoprenyl alkanoates

Lee, Taek Soon; Fortman, Jeffrey L.; Keasling, Jay D.

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Title: Host cells and methods for producing isoprenyl alkanoates

Abstract

The invention provides for a method of producing an isoprenyl alkanoate in a genetically modified host cell. In one embodiment, the method comprises culturing a genetically modified host cell which expresses an enzyme capable of catalyzing the esterification of an isoprenol and a straight-chain fatty acid, such as an alcohol acetyltransferase (AAT), wax ester synthase/diacylglycerol acyltransferase (WS/DGAT) or lipase, under a suitable condition so that the isoprenyl alkanoate is produced.

Inventors:: Lee, Taek Soon; Fortman, Jeffrey L.; Keasling, Jay D.

Issue Date:: 2015-12-01

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1227365

Patent Number(s):: 9200298

Application Number:: 12/644,531

Assignee:: The Regents of the University of California

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N1/18 - Baker's yeast
C12N1/20 - Bacteria {

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P7/62 - Carboxylic acid esters {

Show less

DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 2009 Dec 22

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Lee, Taek Soon, Fortman, Jeffrey L., and Keasling, Jay D. Host cells and methods for producing isoprenyl alkanoates.  United States: N. p., 2015. 
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                    Lee, Taek Soon, Fortman, Jeffrey L., & Keasling, Jay D. Host cells and methods for producing isoprenyl alkanoates.  United States.

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                    Lee, Taek Soon, Fortman, Jeffrey L., and Keasling, Jay D. Tue .  
        "Host cells and methods for producing isoprenyl alkanoates".  United States.  https://www.osti.gov/servlets/purl/1227365.

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@article{osti_1227365,

  title        = {Host cells and methods for producing isoprenyl alkanoates},

  author       = {Lee, Taek Soon and Fortman, Jeffrey L. and Keasling, Jay D.},

  abstractNote = {The invention provides for a method of producing an isoprenyl alkanoate in a genetically modified host cell. In one embodiment, the method comprises culturing a genetically modified host cell which expresses an enzyme capable of catalyzing the esterification of an isoprenol and a straight-chain fatty acid, such as an alcohol acetyltransferase (AAT), wax ester synthase/diacylglycerol acyltransferase (WS/DGAT) or lipase, under a suitable condition so that the isoprenyl alkanoate is produced.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {12}

}

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Title: Host cells and methods for producing isoprenyl alkanoates

Abstract

Citation Formats

Process for amplifying, detecting, and/or-cloning nucleic acid sequences patent, July 1987

Method and composition for increasing the accumulation of squalene and specific sterols in yeast patent, October 1995

Alcohol acetyltransferase genes and use thereof patent, May 1996

Alcohol acetyltransferase genes and use thereof patent, March 1998

Emergency fuel for use in an internal combustion engine patent, December 1998

Nucleic and amino acid sequences relating to a novel transketolase, and methods for the expression thereof patent, February 2001

Limonene and other downstream metabolites of geranyl pyrophosphate for insect control in plants patent, September 2001

Fuel composition for gasoline powered vehicle and method patent, March 2002

Method of producing geranylgeraniol patent, March 2003

Production of farnesol and geranylgeraniol patent, February 2004

Methods and compositions for modification of lipid biosynthesis patent, October 2006

Biosynthesis of isopentenyl pyrophosphate patent, February 2007

Method for enhancing production of isoprenoid compounds patent, February 2007

Biosynthesis of amorpha-4,11-diene patent, March 2007

Geranyl diphosphate synthase molecules, and nucleic acid molecules encoding same patent, June 2008

Process for Producing Prenyl Alcohol patent-application, April 2004

Drug metabolizing enzymes patent-application, June 2004

Natural Flavors Produced by Biotechnological Processing book, February 1989

On the mechanism of action of the antifungal agent propionate: Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans journal, July 2004

The tac promoter: a functional hybrid derived from the trp and lac promoters journal, January 1983

Two Novel Thioesterases Are Key Determinants of the Bimodal Distribution of Acyl Chain Length of Cuphea palustris Seed Oil journal, January 1996

Ethanol Can Contribute to Energy and Environmental Goals journal, January 2006

Lessons from the rifamycin biosynthetic gene cluster journal, October 1999

Nucleotide sequences of alcohol acetyltransferase genes from lager brewing yeast, Saccharomyces carlsbergensis journal, May 1996

Bioethanol journal, April 2006

Cloning of a Gene Cluster Encoding Enzymes Responsible for the Mevalonate Pathway from a Terpenoid-antibiotic-producing Streptomyces Strain journal, January 2001

Hexanoate Synthase, a Specialized Type I Fatty Acid Synthase in Aflatoxin B1 Biosynthesis journal, October 2001

Heterologous expression of the Saccharomyces cerevisiae alcohol acetyltransferase genes in Clostridium acetobutylicum and Escherichia coli for the production of isoamyl acetate journal, July 2003

Characterization of Geraniol Synthase from the Peltate Glands of Sweet Basil journal, December 2003

Metabolic Engineering to Produce Sesquiterpenes in Yeast journal, May 2003

Synthesis of Novel Lipids in Saccharomyces cerevisiae by Heterologous Expression of an Unspecific Bacterial Acyltransferase journal, December 2004

In vitro andin vivo biosynthesis of wax diesters by an unspecific bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase fromAcinetobacter calcoaceticus ADP1 journal, October 2003

A Novel Bifunctional Wax Ester Synthase/Acyl-CoA:Diacylglycerol Acyltransferase Mediates Wax Ester and Triacylglycerol Biosynthesis in Acinetobacter calcoaceticus ADP1 journal, December 2002

Microdiesel: Escherichia coli engineered for fuel production journal, September 2006

Heterologous Mevalonate Production in Streptomyces lividans TK23 journal, January 2004

Fatty Acid Synthesis by Elongases in Trypanosomes journal, August 2006

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids journal, June 2003

Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production journal, August 2003

Expression in Escherichia coli, purification and characterization of two mammalian thioesterases involved in fatty acid synthesis journal, February 1991

Toxicity Caused by Hydroxycinnamoyl-Coenzyme A Thioester Accumulation in Mutants of Acinetobacter sp. Strain ADP1 journal, May 2004

Ethanol Production Using Corn, Switchgrass, and Wood; Biodiesel Production Using Soybean and Sunflower journal, March 2005

Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast journal, January 1998

A specific acyl-ACP thioesterase implicated in medium-chain fatty acid production in immature cotyledons of Umbellularia californica journal, February 1991

Mechanisms of Solvent Tolerance in Gram-Negative Bacteria journal, October 2002

Mono and diterpene production in Escherichia coli journal, January 2004

Production of the antimalarial drug precursor artemisinic acid in engineered yeast journal, April 2006

New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis journal, March 2007

A Soluble Form of Phosphatase in Saccharomyces cerevisiae Capable of Converting Farnesyl Diphosphate Into E-E Farnesol journal, January 2006

The Wax Ester Synthase/Acyl Coenzyme A:Diacylglycerol Acyltransferase from Acinetobacter sp. Strain ADP1: Characterization of a Novel Type of Acyltransferase journal, February 2005

Thio Wax Ester Biosynthesis Utilizing the Unspecific Bifunctional Wax Ester Synthase/Acyl Coenzyme A:Diacylglycerol Acyltransferase of Acinetobacter sp. Strain ADP1 journal, February 2005

Naturally Transformable Acinetobacter sp. Strain ADP1 Belongs to the Newly Described Species Acinetobacter baylyi journal, January 2006

Expression Levels of the Yeast Alcohol Acetyltransferase Genes ATF1, Lg-ATF1, and ATF2 Control the Formation of a Broad Range of Volatile Esters journal, September 2003

The Structural Biology of type ii Fatty acid Biosynthesis journal, June 2005

Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci journal, August 2000

Process for amplifying, detecting, and/or-cloning nucleic acid sequences
patent, July 1987

Method and composition for increasing the accumulation of squalene and specific sterols in yeast
patent, October 1995

Alcohol acetyltransferase genes and use thereof
patent, May 1996

Alcohol acetyltransferase genes and use thereof
patent, March 1998

Emergency fuel for use in an internal combustion engine
patent, December 1998

Nucleic and amino acid sequences relating to a novel transketolase, and methods for the expression thereof
patent, February 2001

Limonene and other downstream metabolites of geranyl pyrophosphate for insect control in plants
patent, September 2001

Fuel composition for gasoline powered vehicle and method
patent, March 2002

Method of producing geranylgeraniol
patent, March 2003

Production of farnesol and geranylgeraniol
patent, February 2004

Methods and compositions for modification of lipid biosynthesis
patent, October 2006

Biosynthesis of isopentenyl pyrophosphate
patent, February 2007

Method for enhancing production of isoprenoid compounds
patent, February 2007

Biosynthesis of amorpha-4,11-diene
patent, March 2007

Geranyl diphosphate synthase molecules, and nucleic acid molecules encoding same
patent, June 2008

Process for Producing Prenyl Alcohol
patent-application, April 2004

Drug metabolizing enzymes
patent-application, June 2004

Natural Flavors Produced by Biotechnological Processing
book, February 1989

On the mechanism of action of the antifungal agent propionate: Propionyl-CoA inhibits glucose metabolism in Aspergillus nidulans
journal, July 2004

The tac promoter: a functional hybrid derived from the trp and lac promoters
journal, January 1983

Two Novel Thioesterases Are Key Determinants of the Bimodal Distribution of Acyl Chain Length of Cuphea palustris Seed Oil
journal, January 1996

Ethanol Can Contribute to Energy and Environmental Goals
journal, January 2006

Lessons from the rifamycin biosynthetic gene cluster
journal, October 1999

Nucleotide sequences of alcohol acetyltransferase genes from lager brewing yeast, Saccharomyces carlsbergensis
journal, May 1996

Bioethanol
journal, April 2006

Cloning of a Gene Cluster Encoding Enzymes Responsible for the Mevalonate Pathway from a Terpenoid-antibiotic-producing Streptomyces Strain
journal, January 2001

Hexanoate Synthase, a Specialized Type I Fatty Acid Synthase in Aflatoxin B1 Biosynthesis
journal, October 2001

Heterologous expression of the Saccharomyces cerevisiae alcohol acetyltransferase genes in Clostridium acetobutylicum and Escherichia coli for the production of isoamyl acetate
journal, July 2003

Characterization of Geraniol Synthase from the Peltate Glands of Sweet Basil
journal, December 2003

Metabolic Engineering to Produce Sesquiterpenes in Yeast
journal, May 2003

Synthesis of Novel Lipids in Saccharomyces cerevisiae by Heterologous Expression of an Unspecific Bacterial Acyltransferase
journal, December 2004

In vitro andin vivo biosynthesis of wax diesters by an unspecific bifunctional wax ester synthase/acyl-CoA:diacylglycerol acyltransferase fromAcinetobacter calcoaceticus ADP1
journal, October 2003

A Novel Bifunctional Wax Ester Synthase/Acyl-CoA:Diacylglycerol Acyltransferase Mediates Wax Ester and Triacylglycerol Biosynthesis in Acinetobacter calcoaceticus ADP1
journal, December 2002

Microdiesel: Escherichia coli engineered for fuel production
journal, September 2006

Heterologous Mevalonate Production in Streptomyces lividans TK23
journal, January 2004

Fatty Acid Synthesis by Elongases in Trypanosomes
journal, August 2006

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids
journal, June 2003

Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production
journal, August 2003

Expression in Escherichia coli, purification and characterization of two mammalian thioesterases involved in fatty acid synthesis
journal, February 1991

Toxicity Caused by Hydroxycinnamoyl-Coenzyme A Thioester Accumulation in Mutants of Acinetobacter sp. Strain ADP1
journal, May 2004

Ethanol Production Using Corn, Switchgrass, and Wood; Biodiesel Production Using Soybean and Sunflower
journal, March 2005

Overexpression of a cytosolic hydroxymethylglutaryl-CoA reductase leads to squalene accumulation in yeast
journal, January 1998

A specific acyl-ACP thioesterase implicated in medium-chain fatty acid production in immature cotyledons of Umbellularia californica
journal, February 1991

Mechanisms of Solvent Tolerance in Gram-Negative Bacteria
journal, October 2002

Mono and diterpene production in Escherichia coli
journal, January 2004

Production of the antimalarial drug precursor artemisinic acid in engineered yeast
journal, April 2006

New insights into Acinetobacter baumannii pathogenesis revealed by high-density pyrosequencing and transposon mutagenesis
journal, March 2007

A Soluble Form of Phosphatase in Saccharomyces cerevisiae Capable of Converting Farnesyl Diphosphate Into E-E Farnesol
journal, January 2006

The Wax Ester Synthase/Acyl Coenzyme A:Diacylglycerol Acyltransferase from Acinetobacter sp. Strain ADP1: Characterization of a Novel Type of Acyltransferase
journal, February 2005

Thio Wax Ester Biosynthesis Utilizing the Unspecific Bifunctional Wax Ester Synthase/Acyl Coenzyme A:Diacylglycerol Acyltransferase of Acinetobacter sp. Strain ADP1
journal, February 2005

Naturally Transformable Acinetobacter sp. Strain ADP1 Belongs to the Newly Described Species Acinetobacter baylyi
journal, January 2006

Expression Levels of the Yeast Alcohol Acetyltransferase Genes ATF1, Lg-ATF1, and ATF2 Control the Formation of a Broad Range of Volatile Esters
journal, September 2003

The Structural Biology of type ii Fatty acid Biosynthesis
journal, June 2005

Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci
journal, August 2000