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Title: Combined hairpin-antisense compositions and methods for modulating expression

A nucleotide construct comprising a nucleotide sequence that forms a stem and a loop, wherein the loop comprises a nucleotide sequence that modulates expression of a target, wherein the stem comprises a nucleotide sequence that modulates expression of a target, and wherein the target modulated by the nucleotide sequence in the loop and the target modulated by the nucleotide sequence in the stem may be the same or different. Vectors, methods of regulating target expression, methods of providing a cell, and methods of treating conditions comprising the nucleotide sequence are also disclosed.
Inventors:
;
Issue Date:
OSTI Identifier:
1226826
Assignee:
Brookhaven Science Associates, LLC (Upton, NY) BNL
Patent Number(s):
9,193,972
Application Number:
14/452,049
Contract Number:
AC02-98CH10886
Resource Relation:
Patent File Date: 2014 Aug 05
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

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