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Title: Combined hairpin-antisense compositions and methods for modulating expression

Abstract

A nucleotide construct comprising a nucleotide sequence that forms a stem and a loop, wherein the loop comprises a nucleotide sequence that modulates expression of a target, wherein the stem comprises a nucleotide sequence that modulates expression of a target, and wherein the target modulated by the nucleotide sequence in the loop and the target modulated by the nucleotide sequence in the stem may be the same or different. Vectors, methods of regulating target expression, methods of providing a cell, and methods of treating conditions comprising the nucleotide sequence are also disclosed.

Inventors:
;
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1226826
Patent Number(s):
9193972
Application Number:
14/452,049
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Resource Relation:
Patent File Date: 2014 Aug 05
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Shanklin, John, and Nguyen, Tam Huu. Combined hairpin-antisense compositions and methods for modulating expression. United States: N. p., 2015. Web.
Shanklin, John, & Nguyen, Tam Huu. Combined hairpin-antisense compositions and methods for modulating expression. United States.
Shanklin, John, and Nguyen, Tam Huu. Tue . "Combined hairpin-antisense compositions and methods for modulating expression". United States. https://www.osti.gov/servlets/purl/1226826.
@article{osti_1226826,
title = {Combined hairpin-antisense compositions and methods for modulating expression},
author = {Shanklin, John and Nguyen, Tam Huu},
abstractNote = {A nucleotide construct comprising a nucleotide sequence that forms a stem and a loop, wherein the loop comprises a nucleotide sequence that modulates expression of a target, wherein the stem comprises a nucleotide sequence that modulates expression of a target, and wherein the target modulated by the nucleotide sequence in the loop and the target modulated by the nucleotide sequence in the stem may be the same or different. Vectors, methods of regulating target expression, methods of providing a cell, and methods of treating conditions comprising the nucleotide sequence are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {11}
}

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