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Title: Microfluidic devices, systems, and methods for quantifying particles using centrifugal force

Embodiments of the present invention are directed toward microfluidic systems, apparatus, and methods for measuring a quantity of cells in a fluid. Examples include a differential white blood cell measurement using a centrifugal microfluidic system. A method may include introducing a fluid sample containing a quantity of cells into a microfluidic channel defined in part by a substrate. The quantity of cells may be transported toward a detection region defined in part by the substrate, wherein the detection region contains a density media, and wherein the density media has a density lower than a density of the cells and higher than a density of the fluid sample. The substrate may be spun such that at least a portion of the quantity of cells are transported through the density media. Signals may be detected from label moieties affixed to the cells.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1226547
Assignee:
Sandia Corporation (Albuquerque, NM) SNL-A
Patent Number(s):
9,186,668
Application Number:
12/891,956
Contract Number:
AC04-94AL85000
Resource Relation:
Patent File Date: 2010 Sep 28
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS

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