Passive chip-based droplet sorting
Abstract
An apparatus for passive sorting of microdroplets including a main flow channel, a flow stream of microdroplets in the main flow channel wherein the microdroplets have substantially the same diameter and wherein the flow stream of microdroplets includes first microdroplets having a first degree of stiffness and second microdroplets having a second degree of stiffness wherein the second degree of stiffness is different than the first degree of stiffness. A second flow channel is connected to the main flow channel for the second microdroplets having a second degree of stiffness. A separator separates the second microdroplets having a second degree of stiffness from the first microdroplets and directs the second microdroplets having a second degree of stiffness into the second flow channel.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1224965
- Patent Number(s):
- 9174213
- Application Number:
- 14/629,930
- Assignee:
- Lawrence Livermore National Security, LLC
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2015 Feb 24
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 42 ENGINEERING
Citation Formats
Beer, Neil Reginald, Lee, Abraham P, Hatch, Andrew C, and Fisher, Jeffrey S. Passive chip-based droplet sorting. United States: N. p., 2015.
Web.
Beer, Neil Reginald, Lee, Abraham P, Hatch, Andrew C, & Fisher, Jeffrey S. Passive chip-based droplet sorting. United States.
Beer, Neil Reginald, Lee, Abraham P, Hatch, Andrew C, and Fisher, Jeffrey S. Thu .
"Passive chip-based droplet sorting". United States. https://www.osti.gov/servlets/purl/1224965.
@article{osti_1224965,
title = {Passive chip-based droplet sorting},
author = {Beer, Neil Reginald and Lee, Abraham P and Hatch, Andrew C and Fisher, Jeffrey S},
abstractNote = {An apparatus for passive sorting of microdroplets including a main flow channel, a flow stream of microdroplets in the main flow channel wherein the microdroplets have substantially the same diameter and wherein the flow stream of microdroplets includes first microdroplets having a first degree of stiffness and second microdroplets having a second degree of stiffness wherein the second degree of stiffness is different than the first degree of stiffness. A second flow channel is connected to the main flow channel for the second microdroplets having a second degree of stiffness. A separator separates the second microdroplets having a second degree of stiffness from the first microdroplets and directs the second microdroplets having a second degree of stiffness into the second flow channel.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {11}
}
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Works referenced in this record:
Microfluidic magnetophoretic device and methods for using the same
patent, October 2010
- Oh, Sang Hyun; Singh, Amarendra Kumar; Zhang, Yanting
- US Patent Document 7,807,454
Particle quantifying systems and methods using acoustic radiation pressure
patent, November 2012
- Ward, Michael D.; Kaduchak, Gregory
- US Patent Document 8,309,408
Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
patent, April 2013
- Butler, William F.; Chachisvilis, Mirianas; Dees, Robert
- US Patent Document 8,426,209
Manipulation of microfluidic droplets
patent, September 2013
- Miller, Benjamin J.; Hutchison, Brian; Wilson, Andrew
- US Patent Document 8,528,589
Microfabricated crossflow devices and methods
patent-application, May 2002
- Quake, Stephen R.; Thorsen, Todd
- US Patent Application 09/953103; 20020058332
Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
patent-application, September 2005
- Butler, William Frank; Chachisvilis, Mirianas; Dees, Robert
- US Patent Application 10/928650; 20050207940
The Cross-linking of Proteins with Glutaraldehyde and its use for the preparation of immunoadsorbents
journal, January 1969
- Avrameas, Stratis; Ternynck, Thérèse
- Immunochemistry, Vol. 6, Issue 1, p. 53-66
Isothermal surface production and regulation for high heat flux applications utilizing porous inserts
journal, August 2001
- Khanafer, K.; Vafai, K.
- International Journal of Heat and Mass Transfer, Vol. 44, Issue 15, p. 2933-2947
Inducing and Sensing Protein–Protein Interactions in Living Cells by Selective Cross-linking
journal, June 2007
- Lemercier, Guillaume; Gendreizig, Susanne; Kindermann, Maik
- Angewandte Chemie International Edition, Vol. 46, Issue 23, p. 4281-4284
Self-Assembly and Cross-Linking of Bionanoparticles at Liquid-Liquid Interfaces
journal, April 2005
- Russell, Justin T.; Lin, Yao; Böker, Alexander
- Angewandte Chemie International Edition, Vol. 44, Issue 16, p. 2420-2426
Metal-Mediated Self-Assembly of Protein Superstructures: Influence of Secondary Interactions on Protein Oligomerization and Aggregation
journal, May 2008
- Salgado, Eric N.; Lewis, Richard A.; Faraone-Mennella, Jasmin
- Journal of the American Chemical Society, Vol. 130, Issue 19
Photo-leucine and photo-methionine allow identification of protein-protein interactions in living cells
journal, March 2005
- Suchanek, Monika; Radzikowska, Anna; Thiele, Christoph
- Nature Methods, Vol. 2, Issue 4