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Title: Ketol-acid reductoisomerase enzymes and methods of use


Provided herein are polypeptides having ketol-aid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways.

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Issue Date:
Research Org.:
Butamax Advanced Biofuels LLC, Wilmington, DE (United States)
Sponsoring Org.:
OSTI Identifier:
Patent Number(s):
Application Number:
Butamax Advanced Biofuels LLC (Wilmington, DE)
DOE Contract Number:  
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Patent File Date: 2013 May 10
Country of Publication:
United States

Citation Formats

Govindarajan, Sridhar, Li, Yougen, Liao, Der-Ing, O'Keefe, Daniel P., Minshull, Jeremy Stephen, Rothman, Steven Cary, and Tobias, Alexander Vincent. Ketol-acid reductoisomerase enzymes and methods of use. United States: N. p., 2015. Web.
Govindarajan, Sridhar, Li, Yougen, Liao, Der-Ing, O'Keefe, Daniel P., Minshull, Jeremy Stephen, Rothman, Steven Cary, & Tobias, Alexander Vincent. Ketol-acid reductoisomerase enzymes and methods of use. United States.
Govindarajan, Sridhar, Li, Yougen, Liao, Der-Ing, O'Keefe, Daniel P., Minshull, Jeremy Stephen, Rothman, Steven Cary, and Tobias, Alexander Vincent. Tue . "Ketol-acid reductoisomerase enzymes and methods of use". United States.
title = {Ketol-acid reductoisomerase enzymes and methods of use},
author = {Govindarajan, Sridhar and Li, Yougen and Liao, Der-Ing and O'Keefe, Daniel P. and Minshull, Jeremy Stephen and Rothman, Steven Cary and Tobias, Alexander Vincent},
abstractNote = {Provided herein are polypeptides having ketol-aid reductoisomerase activity as well as microbial host cells comprising such polypeptides. Polypeptides provided herein may be used in biosynthetic pathways, including, but not limited to, isobutanol biosynthetic pathways.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {10}


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