Accurate and rapid micromixer for integrated microfluidic devices

Title: Accurate and rapid micromixer for integrated microfluidic devices

The invention may provide a microfluidic mixer having a droplet generator and a droplet mixer in selective fluid connection with the droplet generator. The droplet generator comprises first and second fluid chambers that are structured to be filled with respective first and second fluids that can each be held in isolation for a selectable period of time. The first and second fluid chambers are further structured to be reconfigured into a single combined chamber to allow the first and second fluids in the first and second fluid chambers to come into fluid contact with each other in the combined chamber for a selectable period of time prior to being brought into the droplet mixer.

Inventors:: Van Dam, R. Michael; Liu, Kan; Shen, Kwang -Fu Clifton; Tseng, Hsian -Rong

Issue Date:: 2015-09-22

OSTI Identifier:: 1221397

Assignee:: The Regents of the University of California (Oakland, CA) CHO

Patent Number(s):: 9,138,700

Application Number:: 12/863,276

Contract Number:: FG02-06ER64249

Resource Relation:: Patent File Date: 2009 Jan 21

Research Org:: The Regents of the University of California, Oakland, CA (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

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Other works cited in this record:

Micromixers—a review on passive and active mixing principles
journal, April 2005

Hessel, Volker; Löwe, Holger; Schönfeld, Friedhelm
Chemical Engineering Science, Vol. 60, Issue 8-9, p. 2479-2501
DOI: 10.1016/j.ces.2004.11.033

Reactions in Droplets in Microfluidic Channels
journal, November 2006

Song, Helen; Chen, Delai L.; Ismagilov, Rustem F.
Angewandte Chemie International Edition, Vol. 45, Issue 44, p. 7336-7356
DOI: 10.1002/anie.200601554

Effects of viscosity on droplet formation and mixing in microfluidic channels
journal, April 2004

Tice, Joshua D.; Lyon, Adam D.; Ismagilov, Rustem F.
Analytica Chimica Acta, Vol. 507, Issue 1, p. 73-77
DOI: 10.1016/j.aca.2003.11.024

From The Cover: Systematic investigation of protein phase behavior with a microfluidic formulator
journal, September 2004

Hansen, C. L.; Sommer, M. O. A.; Quake, S. R.
Proceedings of the National Academy of Sciences, Vol. 101, Issue 40, p. 14431-14436
DOI: 10.1073/pnas.0405847101

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