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Title: Fluorescence dye tagging scheme for mercury quantification and speciation

Abstract

A fluorescent dye or fluorophore capable of forming complexes with mercury comprises 6,8-difluoro-7-hydroxy-2-oxo-2H-chromene-3-carboxylate amide, wherein the amide is formed by reacting the succinimidyl ester (Pacific Blue.TM.) with an amino acid containing a thiol group, such as cysteine or glutathione. Mercury complexes of the fluorophore fluoresce when excited by a UV or violet laser diode, and the detected intensity can be calibrated to quantify the concentration of mercury in a sample reacted with the fluorophore.

Inventors:
;
Issue Date:
Research Org.:
Los Gatos Research, Mountain View, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1221386
Patent Number(s):
9139550
Application Number:
13/570,548
Assignee:
Los Gatos Research (Mountain View, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
SC0004430
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Aug 09
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Jiao, Hong, and Catterall, Hannah. Fluorescence dye tagging scheme for mercury quantification and speciation. United States: N. p., 2015. Web.
Jiao, Hong, & Catterall, Hannah. Fluorescence dye tagging scheme for mercury quantification and speciation. United States.
Jiao, Hong, and Catterall, Hannah. Tue . "Fluorescence dye tagging scheme for mercury quantification and speciation". United States. https://www.osti.gov/servlets/purl/1221386.
@article{osti_1221386,
title = {Fluorescence dye tagging scheme for mercury quantification and speciation},
author = {Jiao, Hong and Catterall, Hannah},
abstractNote = {A fluorescent dye or fluorophore capable of forming complexes with mercury comprises 6,8-difluoro-7-hydroxy-2-oxo-2H-chromene-3-carboxylate amide, wherein the amide is formed by reacting the succinimidyl ester (Pacific Blue.TM.) with an amino acid containing a thiol group, such as cysteine or glutathione. Mercury complexes of the fluorophore fluoresce when excited by a UV or violet laser diode, and the detected intensity can be calibrated to quantify the concentration of mercury in a sample reacted with the fluorophore.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {9}
}

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Works referenced in this record:

Enhanced Amine and Amino Acid Analysis Using Pacific Blue and the Mars Organic Analyzer Microchip Capillary Electrophoresis System
journal, April 2009


Capillary Electrophoresis Analysis of Organic Amines and Amino Acids in Saline and Acidic Samples Using the Mars Organic Analyzer
journal, November 2009


Toward Total Automation of Microfluidics for Extraterrestial In Situ Analysis
journal, November 2011