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Title: Enhanced spot preparation for liquid extractive sampling and analysis

Abstract

A method for performing surface sampling of an analyte, includes the step of placing the analyte on a stage with a material in molar excess to the analyte, such that analyte-analyte interactions are prevented and the analyte can be solubilized for further analysis. The material can be a matrix material that is mixed with the analyte. The material can be provided on a sample support. The analyte can then be contacted with a solvent to extract the analyte for further processing, such as by electrospray mass spectrometry.

Inventors:
;
Issue Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1215631
Patent Number(s):
9,140,633
Application Number:
13/488,141
Assignee:
UT-Battelle, LLC (Oak Ridge, TN)
DOE Contract Number:  
AC05-00OR22725
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Jun 04
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Van Berkel, Gary J., and King, Richard C. Enhanced spot preparation for liquid extractive sampling and analysis. United States: N. p., 2015. Web.
Van Berkel, Gary J., & King, Richard C. Enhanced spot preparation for liquid extractive sampling and analysis. United States.
Van Berkel, Gary J., and King, Richard C. Tue . "Enhanced spot preparation for liquid extractive sampling and analysis". United States. https://www.osti.gov/servlets/purl/1215631.
@article{osti_1215631,
title = {Enhanced spot preparation for liquid extractive sampling and analysis},
author = {Van Berkel, Gary J. and King, Richard C.},
abstractNote = {A method for performing surface sampling of an analyte, includes the step of placing the analyte on a stage with a material in molar excess to the analyte, such that analyte-analyte interactions are prevented and the analyte can be solubilized for further analysis. The material can be a matrix material that is mixed with the analyte. The material can be provided on a sample support. The analyte can then be contacted with a solvent to extract the analyte for further processing, such as by electrospray mass spectrometry.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {9}
}

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Works referenced in this record:

Liquid Microjunction Surface Sampling Probe Fluid Dynamics: Computational and Experimental Analysis of Coaxial Intercapillary Positioning Effects on Sample Manipulation
journal, April 2011

  • ElNaggar, Mariam S.; Barbier, Charlotte; Van Berkel, Gary J.
  • Journal of The American Society for Mass Spectrometry, Vol. 22, Issue 7
  • DOI: 10.1007/s13361-011-0145-5

High-Throughput Mode Liquid Microjunction Surface Sampling Probe
journal, August 2009

  • Van Berkel, Gary J.; Kertesz, Vilmos; King, Richard C.
  • Analytical Chemistry, Vol. 81, Issue 16
  • DOI: 10.1021/ac901098d

Fully automated liquid extraction-based surface sampling and ionization using a chip-based robotic nanoelectrospray platform
journal, March 2010

  • Kertesz, Vilmos; Van Berkel, Gary J.
  • Journal of Mass Spectrometry, Vol. 45, Issue 3
  • DOI: 10.1002/jms.1709