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Title: Polypeptide having cellobiohydrolase activity and uses thereof

Abstract

The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 93% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 93% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.

Inventors:
; ; ;
Issue Date:
Research Org.:
DSM IP ASSETS B.V., Heerlen (Netherlands)
Sponsoring Org.:
USDOE
OSTI Identifier:
1215543
Patent Number(s):
9,133,448
Application Number:
13/578,223
Assignee:
DSM IP ASSETS B.V. (Heerlen, NL)
DOE Contract Number:  
FC36-08GO18079
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Feb 11
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Sagt, Cornelis Maria Jacobus, Schooneveld-Bergmans, Margot Elisabeth Francoise, Roubos, Johannes Andries, and Los, Alrik Pieter. Polypeptide having cellobiohydrolase activity and uses thereof. United States: N. p., 2015. Web.
Sagt, Cornelis Maria Jacobus, Schooneveld-Bergmans, Margot Elisabeth Francoise, Roubos, Johannes Andries, & Los, Alrik Pieter. Polypeptide having cellobiohydrolase activity and uses thereof. United States.
Sagt, Cornelis Maria Jacobus, Schooneveld-Bergmans, Margot Elisabeth Francoise, Roubos, Johannes Andries, and Los, Alrik Pieter. Tue . "Polypeptide having cellobiohydrolase activity and uses thereof". United States. https://www.osti.gov/servlets/purl/1215543.
@article{osti_1215543,
title = {Polypeptide having cellobiohydrolase activity and uses thereof},
author = {Sagt, Cornelis Maria Jacobus and Schooneveld-Bergmans, Margot Elisabeth Francoise and Roubos, Johannes Andries and Los, Alrik Pieter},
abstractNote = {The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 93% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 93% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {9}
}

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Works referenced in this record:

Crystal structure of the catalytic core domain of the family 6 cellobiohydrolase II, Cel6A, from Humicola insolens, at 1.92 Å resolution
journal, January 1999

  • Varrot, Annabelle; Hastrup, Sven; SchÜLein, Martin
  • Biochemical Journal, Vol. 337, Issue 2
  • DOI: 10.1042/bj3370297

Correlation between cellulose binding and activity of cellulose-binding domain mutants of Humicola grisea cellobiohydrolase 1
journal, December 2007