Biomarkers for liver fibrosis
Abstract
Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.
- Inventors:
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1214595
- Patent Number(s):
- 9134326
- Application Number:
- 14/209,860
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC05-76RL01830
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2014 Mar 13
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Jacobs, Jon M., Burnum-Johnson, Kristin E., Baker, Erin M., Smith, Richard D., Gritsenko, Marina A., and Orton, Daniel. Biomarkers for liver fibrosis. United States: N. p., 2015.
Web.
Jacobs, Jon M., Burnum-Johnson, Kristin E., Baker, Erin M., Smith, Richard D., Gritsenko, Marina A., & Orton, Daniel. Biomarkers for liver fibrosis. United States.
Jacobs, Jon M., Burnum-Johnson, Kristin E., Baker, Erin M., Smith, Richard D., Gritsenko, Marina A., and Orton, Daniel. Tue .
"Biomarkers for liver fibrosis". United States. https://www.osti.gov/servlets/purl/1214595.
@article{osti_1214595,
title = {Biomarkers for liver fibrosis},
author = {Jacobs, Jon M. and Burnum-Johnson, Kristin E. and Baker, Erin M. and Smith, Richard D. and Gritsenko, Marina A. and Orton, Daniel},
abstractNote = {Methods and systems for diagnosing or prognosing liver fibrosis in a subject are provided. In some examples, such methods and systems can include detecting liver fibrosis-related molecules in a sample obtained from the subject, comparing expression of the molecules in the sample to controls representing expression values expected in a subject who does not have liver fibrosis or who has non-progressing fibrosis, and diagnosing or prognosing liver fibrosis in the subject when differential expression of the molecules between the sample and the controls is detected. Kits for the diagnosis or prognosis of liver fibrosis in a subject are also provided which include reagents for detecting liver fibrosis related molecules.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {9}
}
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