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Title: Polypeptide having carbohydrate degrading activity and uses thereof

The invention relates to a polypeptide comprising the amino acid sequence set out in SEQ ID NO: 2 or an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 1, or a variant polypeptide or variant polynucleotide thereof, wherein the variant polypeptide has at least 73% sequence identity with the sequence set out in SEQ ID NO: 2 or the variant polynucleotide encodes a polypeptide that has at least 73% sequence identity with the sequence set out in SEQ ID NO: 2. The invention features the full length coding sequence of the novel gene as well as the amino acid sequence of the full-length functional polypeptide and functional equivalents of the gene or the amino acid sequence. The invention also relates to methods for using the polypeptide in industrial processes. Also included in the invention are cells transformed with a polynucleotide according to the invention suitable for producing these proteins.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
1210881
Assignee:
DSM IP ASSETS B.V. (Heerlen, NL) GFO
Patent Number(s):
9,109,213
Application Number:
13/806,132
Contract Number:
FC36-08GO18079
Resource Relation:
Patent File Date: 2011 Jun 23
Research Org:
DSM IP ASSETS B.V., Heerlen (Netherlands)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Other works cited in this record:

Molecular cloning and expression analysis of two distinct β-glucosidase genes, bg1 and aven1, with very different biological roles from the thermophilic, saprophytic fungus Talaromyces emersonii
journal, July 2007
  • Collins, Catherine M.; Murray, Patrick G.; Denman, Stuart
  • Mycological Research, Vol. 111, Issue 7, p. 840-849
  • DOI: 10.1016/j.mycres.2007.05.007

Expression in Trichoderma reesei and characterisation of a thermostable family 3 β-glucosidase from the moderately thermophilic fungus Talaromyces emersonii
journal, December 2004
  • Murray, Patrick; Aro, Nina; Collins, Catherine
  • Protein Expression and Purification, Vol. 38, Issue 2, p. 248-257
  • DOI: 10.1016/j.pep.2004.08.006

Catalytic properties and mode of action of three endo-β-glucanases from Talaromyces emersonii on soluble β-1,4- and β-1,3;1,4-linked glucans
journal, November 2003
  • McCarthy, Tracey; Hanniffy, Orla; Savage, Angela V.
  • International Journal of Biological Macromolecules, Vol. 33, Issue 1-3, p. 141-148
  • DOI: 10.1016/S0141-8130(03)00080-1

Molecular cloning, transcriptional, and expression analysis of the first cellulase gene (cbh2), encoding cellobiohydrolase II, from the moderately thermophilic fungus Talaromyces emersonii and structure prediction of the gene product
journal, February 2003
  • Murray, P. G.; Collins, C. M.; Grassick, A.
  • Biochemical and Biophysical Research Communications, Vol. 301, Issue 2, p. 280-286
  • DOI: 10.1016/S0006-291X(02)03025-5

Stimulation of Lignocellulosic Biomass Hydrolysis by Proteins of Glycoside Hydrolase Family 61 Structure and Function of a Large, Enigmatic Family
journal, April 2010
  • Harris, Paul; Welner, Ditte; McFarland, K.
  • Biochemistry, Vol. 49, Issue 15, p. 3305-3316
  • DOI: 10.1021/bi100009p

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