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Title: Fiber optical asssembly for fluorescence spectrometry

Abstract

System is provided for detecting the presence of an analyte of interest in a sample, said system comprising an elongated, transparent container for a sample; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the sample, and wherein the radiation induces a signal which is emitted from the sample; and, at least two linear arrays disposed about the sample holder, each linear array comprising a plurality of optical fibers having a first end and a second end, wherein the first ends of the fibers are disposed along the length of the container and in proximity thereto; the second ends of the fibers of each array are bundled together to form a single end port.

Inventors:
; ;
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1210861
Patent Number(s):
9110024
Application Number:
13/258,727
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Mar 25
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats

Piltch, Martin S., Gray, Perry Clayton, and Rubenstein, Richard. Fiber optical asssembly for fluorescence spectrometry. United States: N. p., 2015. Web.
Piltch, Martin S., Gray, Perry Clayton, & Rubenstein, Richard. Fiber optical asssembly for fluorescence spectrometry. United States.
Piltch, Martin S., Gray, Perry Clayton, and Rubenstein, Richard. Tue . "Fiber optical asssembly for fluorescence spectrometry". United States. https://www.osti.gov/servlets/purl/1210861.
@article{osti_1210861,
title = {Fiber optical asssembly for fluorescence spectrometry},
author = {Piltch, Martin S. and Gray, Perry Clayton and Rubenstein, Richard},
abstractNote = {System is provided for detecting the presence of an analyte of interest in a sample, said system comprising an elongated, transparent container for a sample; an excitation source in optical communication with the sample, wherein radiation from the excitation source is directed along the length of the sample, and wherein the radiation induces a signal which is emitted from the sample; and, at least two linear arrays disposed about the sample holder, each linear array comprising a plurality of optical fibers having a first end and a second end, wherein the first ends of the fibers are disposed along the length of the container and in proximity thereto; the second ends of the fibers of each array are bundled together to form a single end port.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {8}
}

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Works referenced in this record:

Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking
journal, March 2008


Autocatalytic self-propagation of misfolded prion protein
journal, August 2004


Normal prion protein has an activity like that of superoxide dismutase
journal, November 1999


Detection of prions in blood
journal, August 2005


In Vitro Generation of Infectious Scrapie Prions
journal, April 2005


PrP antibody binding-induced epitope modulation evokes immunocooperativity
journal, December 2008


Surround optical fiber immunoassay (SOFIA): An ultra-sensitive assay for prion protein detection
journal, July 2009


Protease-resistant Prion Protein Amplification Reconstituted with Partially Purified Substrates and Synthetic Polyanions
journal, May 2005


Diagnosis of Transmissible Spongiform Encephalopathies in Animals: A Review
journal, November 2005


Role of lymph-borne cells in the early stages of scrapie agent dissemination from the skin
journal, February 2006


Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay
journal, March 2009


A rapid and efficient method to enrich SAF-protein from scrapie brains of hamsters
journal, February 1984


Transmission of BSE by blood transfusion in sheep
journal, September 2000


In vitro amplification and detection of variant Creutzfeldt–Jakob disease PrPSc
journal, January 2007


Preferential Cu 2+ Coordination by His 96 and His 111 Induces β-Sheet Formation in the Unstructured Amyloidogenic Region of the Prion Protein
journal, May 2004


Guanidine hydrochloride extraction and detection of prion proteins in mouse and hamster prion diseases by ELISA
journal, January 2003


Comparison of PrP transcription and translation in two murine myeloma cell lines
journal, July 2003


Cell-free formation of protease-resistant prion protein
journal, August 1994


Efficient In Vitro Amplification of Chronic Wasting Disease PrPRES
journal, June 2007


Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC
journal, December 2006


Characterization of prion protein (PrP)-derived peptides that discriminate full-length PrPSc from PrPC
journal, June 2007


Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion
journal, February 2004


Abnormal prion protein in genetically resistant sheep from a scrapie-infected flock
journal, November 2004


Infectious Prions in the Saliva and Blood of Deer with Chronic Wasting Disease
journal, October 2006


Urinary excretion and blood level of prions in scrapie-infected hamsters
journal, October 2007


Preclinical vCJD after blood transfusion in a PRNP codon 129 heterozygous patient
journal, August 2004


Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication
journal, November 1990


Presymptomatic Detection of Prions in Blood
journal, July 2006


Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding
journal, June 2001


Pre-symptomatic detection of prions by cyclic amplification of protein misfolding
journal, December 2004


Asymptomatic deer excrete infectious prions in faeces
journal, September 2009


Disease-Associated Prion Protein Elicits Immunoglobulin M Responses In Vivo
journal, July 2004


In vitro amplification of PrPSc derived from the brain and blood of sheep infected with scrapie
journal, December 2008


Immumohistochemical Detection and Localization of Prion Protein in Brain Tissue of Sheep With Natural Scrapie
journal, May 1995


PrPCWD in rectal lymphoid tissue of deer (Odocoileus spp.)
journal, July 2007