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  • Orthogonal translation components for the in vivo incorporation of unnatural amino acids

Title: Orthogonal translation components for the in vivo incorporation of unnatural amino acids

The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
Inventors:
; ; ; ; ; ; ; ; ; ; ; ;
Issue Date:
OSTI Identifier:
1209477
Assignee:
The Scripps Research Institute (La Jolla, CA) CHO
Patent Number(s):
9,102,932
Application Number:
13/492,296
Contract Number:
FG03-00ER45601
Resource Relation:
Patent File Date: 2012 Jun 08
Research Org:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES
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Works referenced in this record:

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