Orthogonal translation components for the in vivo incorporation of unnatural amino acids
The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
- Issue Date:
- OSTI Identifier:
- The Scripps Research Institute (La Jolla, CA) CHO
- Patent Number(s):
- Application Number:
- Contract Number:
- Resource Relation:
- Patent File Date: 2012 Jun 08
- Research Org:
- The Scripps Research Inst., La Jolla, CA (United States)
- Sponsoring Org:
- Country of Publication:
- United States
- 59 BASIC BIOLOGICAL SCIENCES
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journal, January 2005
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Genetic introduction of a diketone-containing amino acid into proteins
journal, October 2006
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Expanding the Genetic Code of Escherichia coli
journal, April 2001
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