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Title: Orthogonal translation components for the in vivo incorporation of unnatural amino acids

The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetase that can incorporate unnatural amino acid into proteins produced in eubacterial host cells such as E. coli, or in a eukaryotic host such as a yeast cell. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing unnatural amino acids, and translation systems.
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Issue Date:
OSTI Identifier:
The Scripps Research Institute (La Jolla, CA) CHO
Patent Number(s):
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Contract Number:
Resource Relation:
Patent File Date: 2012 Jun 08
Research Org:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

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