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Title: Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling

A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.
Inventors:
;
Issue Date:
OSTI Identifier:
1207285
Assignee:
The Regents Of The University Of California (Oakland, CA) CHO
Patent Number(s):
9,096,647
Application Number:
13/924,397
Contract Number:
FG02-06ER64249
Resource Relation:
Patent File Date: 2013 Jun 21
Research Org:
The Regents Of The University Of California, Oakland, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Other works cited in this record:

Radiolabelling of isopeptide Nε-(γ-glutamyl)-l-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate
journal, July 2003

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