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Title: Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling

Abstract

A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.

Inventors:
;
Issue Date:
Research Org.:
Univ. of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1207285
Patent Number(s):
9096647
Application Number:
13/924,397
Assignee:
The Regents Of The University Of California (Oakland, CA)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
DOE Contract Number:  
FG02-06ER64249
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Jun 21
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE

Citation Formats

Olma, Sebastian, and Shen, Clifton Kwang-Fu. Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling. United States: N. p., 2015. Web.
Olma, Sebastian, & Shen, Clifton Kwang-Fu. Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling. United States.
Olma, Sebastian, and Shen, Clifton Kwang-Fu. Tue . "Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling". United States. https://www.osti.gov/servlets/purl/1207285.
@article{osti_1207285,
title = {Simplified one-pot synthesis of [.sup.18F]SFB for radiolabeling},
author = {Olma, Sebastian and Shen, Clifton Kwang-Fu},
abstractNote = {A non-aqueous single pot synthesis of [.sup.18F]SFB is set forth. The [.sup.18F]SFB produced with this method is then used, for example, to label a peptide or an engineered antibody fragment (diabody) targeting human epidermal growth factor receptor 2 (HER2) as representative examples of labeled compounds for use as an injectable composition to locate abnormal tissue, specifically tumors within an animal or human using a PET scan.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {8}
}

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Works referenced in this record:

Recent progress in fluorine-18 labelled peptide radiopharmaceuticals
journal, April 2001


Synthesis of Sildenafil Analogues from Anacardic Acid and Their Phosphodiesterase-5 Inhibition
journal, December 2002


Facile synthesis ofN-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB) for protein labeling
journal, January 2008


Radiolabelling of isopeptide Nε-(γ-glutamyl)-l-lysine by conjugation with N-succinimidyl-4-[18F]fluorobenzoate
journal, July 2003