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Title: Genetic barcodes

Herein are described multicolor FISH probe sets termed "genetic barcodes" targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells. Two, three or more different fluorophores are used to detect the genetic barcode sections thus permitting unique labeling and multilocus analysis in individual cell nuclei. Gene specific barcodes can be generated and combined to provide both numerical and structural genetic information for these and other pertinent disease associated genes.
Inventors:
Issue Date:
OSTI Identifier:
1207279
Assignee:
The Regents of the University of California (Oakland, CA) CHO
Patent Number(s):
9,096,902
Application Number:
13/849,452
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2013 Mar 22
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 96 KNOWLEDGE MANAGEMENT AND PRESERVATION

Works referenced in this record:

Preembryo biopsy and analysis of blastomeres by in situ hybridization
journal, December 1990
  • Grifo, Jamie A.; Boyle, Ann; Fischer, Evan
  • American Journal of Obstetrics and Gynecology, Vol. 163, Issue 6, p. 2013-2019
  • DOI: 10.1016/0002-9378(90)90789-A