skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Genetic barcodes

Abstract

Herein are described multicolor FISH probe sets termed "genetic barcodes" targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells. Two, three or more different fluorophores are used to detect the genetic barcode sections thus permitting unique labeling and multilocus analysis in individual cell nuclei. Gene specific barcodes can be generated and combined to provide both numerical and structural genetic information for these and other pertinent disease associated genes.

Inventors:
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1207279
Patent Number(s):
9096902
Application Number:
13/849,452
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2013 Mar 22
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 96 KNOWLEDGE MANAGEMENT AND PRESERVATION

Citation Formats

Weier, Heinz -Ulrich G. Genetic barcodes. United States: N. p., 2015. Web.
Weier, Heinz -Ulrich G. Genetic barcodes. United States.
Weier, Heinz -Ulrich G. Tue . "Genetic barcodes". United States. https://www.osti.gov/servlets/purl/1207279.
@article{osti_1207279,
title = {Genetic barcodes},
author = {Weier, Heinz -Ulrich G},
abstractNote = {Herein are described multicolor FISH probe sets termed "genetic barcodes" targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells. Two, three or more different fluorophores are used to detect the genetic barcode sections thus permitting unique labeling and multilocus analysis in individual cell nuclei. Gene specific barcodes can be generated and combined to provide both numerical and structural genetic information for these and other pertinent disease associated genes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {8}
}

Patent:

Save / Share:

Works referenced in this record:

Preembryo biopsy and analysis of blastomeres by in situ hybridization
journal, December 1990


Karyotyping human chromosomes by combinatorial multi-fluor FISH
journal, April 1996


Preimplantation genetic analysis of translocations: case-specific probes for interphase cell analysis
journal, July 1998


High-performance analysis of single interphase cells with custom DNA probes spanning translocation break points
conference, June 1999


Simultaneous scoring of 10 chromosomes (9,13,14,15,16,18,21,22,X, and Y) in interphase nuclei by using spectral imaging
conference, June 1999


Molecular cloning of translocation breakpoints in a case of constitutional translocation t(11;22)(q23;q11) and preparation of probes for preimplantation genetic diagnosis
journal, January 1999


Cytogenetic analysis of interphase cells using spectral imaging [SIm] technology
conference, March 2000

  • Weier, Heinz-Ulli G.; Smida, Jan; Zitzelsberger, Horst
  • BiOS 2000 The International Symposium on Biomedical Optics, SPIE Proceedings
  • https://doi.org/10.1117/12.379585

Genome scan identifies a locus affecting gamma-globin level in human beta-cluster YAC transgenic mice
journal, November 2000


Case-Specific, Breakpoint-Spanning DNA Probes for Analysis of Single Interphase Cells
journal, September 2000


Multilocus genetic analysis of single interphase cells by spectral imaging
journal, December 2000


Detection of Structural and Numerical Chromosome Abnormalities in Interphase Cells Using Spectral Imaging
journal, June 2001


Multicolor chromosome banding (MCB) with YAC/BAC-based probes and region-specific microdissection DNA libraries
journal, January 2002


Fluorescence In Situ Hybridization and Spectral Imaging Analysis of Human Oocytes and First Polar Bodies
journal, March 2005


Spectral Imaging of Multi-Color Chromogenic Dyes in Pathological Specimens
journal, January 2001