Genetic barcodes

Title: Genetic barcodes

Herein are described multicolor FISH probe sets termed "genetic barcodes" targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells. Two, three or more different fluorophores are used to detect the genetic barcode sections thus permitting unique labeling and multilocus analysis in individual cell nuclei. Gene specific barcodes can be generated and combined to provide both numerical and structural genetic information for these and other pertinent disease associated genes.

Inventors:: Weier, Heinz -Ulrich G

Issue Date:: 2015-08-04

OSTI Identifier:: 1207279

Assignee:: The Regents of the University of California (Oakland, CA) CHO

Patent Number(s):: 9,096,902

Application Number:: 13/849,452

Contract Number:: AC02-05CH11231

Resource Relation:: Patent File Date: 2013 Mar 22

Research Org:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 96 KNOWLEDGE MANAGEMENT AND PRESERVATION

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Works referenced in this record:

Preembryo biopsy and analysis of blastomeres by in situ hybridization
journal, December 1990

Grifo, Jamie A.; Boyle, Ann; Fischer, Evan
American Journal of Obstetrics and Gynecology, Vol. 163, Issue 6, p. 2013-2019
DOI: 10.1016/0002-9378(90)90789-A

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