Genetic barcodes
Abstract
Herein are described multicolor FISH probe sets termed "genetic barcodes" targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells. Two, three or more different fluorophores are used to detect the genetic barcode sections thus permitting unique labeling and multilocus analysis in individual cell nuclei. Gene specific barcodes can be generated and combined to provide both numerical and structural genetic information for these and other pertinent disease associated genes.
- Inventors:
- Issue Date:
- Research Org.:
- Argonne National Laboratory (ANL), Argonne, IL (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1207279
- Patent Number(s):
- 9096902
- Application Number:
- 13/849,452
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2013 Mar 22
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 96 KNOWLEDGE MANAGEMENT AND PRESERVATION
Citation Formats
Weier, Heinz -Ulrich G. Genetic barcodes. United States: N. p., 2015.
Web.
Weier, Heinz -Ulrich G. Genetic barcodes. United States.
Weier, Heinz -Ulrich G. Tue .
"Genetic barcodes". United States. https://www.osti.gov/servlets/purl/1207279.
@article{osti_1207279,
title = {Genetic barcodes},
author = {Weier, Heinz -Ulrich G},
abstractNote = {Herein are described multicolor FISH probe sets termed "genetic barcodes" targeting several cancer or disease-related loci to assess gene rearrangements and copy number changes in tumor cells. Two, three or more different fluorophores are used to detect the genetic barcode sections thus permitting unique labeling and multilocus analysis in individual cell nuclei. Gene specific barcodes can be generated and combined to provide both numerical and structural genetic information for these and other pertinent disease associated genes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 04 00:00:00 EDT 2015},
month = {Tue Aug 04 00:00:00 EDT 2015}
}
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Works referenced in this record:
Preembryo biopsy and analysis of blastomeres by in situ hybridization
journal, December 1990
- Grifo, Jamie A.; Boyle, Ann; Fischer, Evan
- American Journal of Obstetrics and Gynecology, Vol. 163, Issue 6, p. 2013-2019
Karyotyping human chromosomes by combinatorial multi-fluor FISH
journal, April 1996
- Speicher, Michael R.; Ballard, Stephen Gwyn; Ward, David C.
- Nature Genetics, Vol. 12, Issue 4
Carrier-specific breakpoint-spanning DNA probes: an approach to preimplantation genetic diagnosis in interphase cells
journal, September 1997
- Cassel, M. J.; Munne, S.; Fung, J.
- Human Reproduction, Vol. 12, Issue 9
Preimplantation genetic analysis of translocations: case-specific probes for interphase cell analysis
journal, July 1998
- Munné, S.; Fung, Jingly; Cassel, Michael J.
- Human Genetics, Vol. 102, Issue 6
Patient-Specific Probes for Preimplantation Genetic Diagnosis of Structural and Numerical Aberrations in Interphase Cells
journal, April 1999
- Weier, Heinz-Ulli G.; Munné, Santiago; Fung, Jingly
- Journal of Assisted Reproduction and Genetics, Vol. 16, Issue 4, p. 182-191
High-performance analysis of single interphase cells with custom DNA probes spanning translocation break points
conference, June 1999
- Weier, Heinz-Ulli G.; Munne, S.; Lersch, Robert A.
- BiOS '99 International Biomedical Optics Symposium, SPIE Proceedings
Simultaneous scoring of 10 chromosomes (9,13,14,15,16,18,21,22,X, and Y) in interphase nuclei by using spectral imaging
conference, June 1999
- Fung, Jingly; Weier, Heinz-Ulli G.; Goldberg, James D.
- BiOS '99 International Biomedical Optics Symposium, SPIE Proceedings
Cytogenetic analysis of interphase cells using spectral imaging [SIm] technology
conference, March 2000
- Weier, Heinz-Ulli G.; Smida, Jan; Zitzelsberger, Horst
- BiOS 2000 The International Symposium on Biomedical Optics, SPIE Proceedings
Genome scan identifies a locus affecting gamma-globin level in human beta-cluster YAC transgenic mice
journal, November 2000
- Lin, Sluan D.; Cooper, Phil; Fung, Jingly
- Mammalian Genome, Vol. 11, Issue 11
Case-Specific, Breakpoint-Spanning DNA Probes for Analysis of Single Interphase Cells
journal, September 2000
- Lersch, R. A.; Fung, J.; Munné, S.
- Genetic Testing, Vol. 4, Issue 3
Multilocus genetic analysis of single interphase cells by spectral imaging
journal, December 2000
- Fung, J.; Weier, H. -U. G.; Goldberg, J. D.
- Human Genetics, Vol. 107, Issue 6
Detection of chromosome translocation products in single interphase cell nuclei
book, January 2001
- Fung, Jingly; Munné, Santiago; Weier, Heinz-Ulli G.
- Methods in Cell Biology
Detection of Structural and Numerical Chromosome Abnormalities in Interphase Cells Using Spectral Imaging
journal, June 2001
- Fung, Jingly; Weier, H. -Ulli G.; Pedersen, Roger A.
- Journal of Histochemistry & Cytochemistry, Vol. 49, Issue 6
Multicolor chromosome banding (MCB) with YAC/BAC-based probes and region-specific microdissection DNA libraries
journal, January 2002
- Liehr, T.; Weise, A.; Heller, A.
- Cytogenetic and Genome Research, Vol. 97, Issue 1-2
Spectral Imaging of Multi-Color Chromogenic Dyes in Pathological Specimens
journal, January 2001
- Macville, Merryn V. E.; Van der Laak, Jeroen A. W. M.; Speel, Ernst J. M.
- Analytical Cellular Pathology, Vol. 22, Issue 3
Multicolor FISH Techniques for the Detection of Inter- and Intrachromosomal Rearrangements
book, January 2002
- Zitzelsberger, Horst; O’Brien, Benjamin; Weier, Heinz-Ulrich
- FISH Technology
Repeat sequence chromosome specific nucleic acid probes and methods of preparing and using
patent, June 1995
- Weier, Heinz-Ulrich G.; Gray, Joe W.
- US Patent Document 5,427,932
Y chromosome specific nucleic acid probe and method for identifying the Y chromosome in SITU
patent, March 1999
- Gray, Joe W.; Weier, Heinz-Ulrich G.
- US Patent Document 5,888,730
Method for simultaneous detection of multiple fluorophores for in situ hybridization and multicolor chromosome painting and banding
patent, May 2000
- Garini, Yuval; Cabib, Dario; Buckwald, Robert A.
- US Patent Document 6,066,459