Peptides whose uptake by cells is controllable

Jiang, Tao; Olson, Emilia S.; Whitney, Michael; Tsien, Roger

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Title: Peptides whose uptake by cells is controllable

Abstract

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

Inventors:: Jiang, Tao; Olson, Emilia S.; Whitney, Michael; Tsien, Roger

Issue Date:: 2015-07-07

Research Org.:: Univ. of California, Oakland, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1190922

Patent Number(s):: 9072792

Application Number:: 13/155,168

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/00 - Medicinal preparations containing peptides
A61K41/0095 - {Boron neutron capture therapy, i.e. BNCT, e.g. using boronated porphyrins}
A61K47/64 - Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
A61K47/645 - {Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT}
A61K47/65 - Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
A61K49/0032 - {Methine dyes, e.g. cyanine dyes}
A61K49/0043 - {Fluorescein, used in vivo}
A61K49/0056 - {Peptides, proteins, polyamino acids}
A61K49/085 - {conjugated systems}
A61K49/14 - Peptides, e.g. proteins
A61K49/146 - {the peptide being a polyamino acid, e.g. poly-lysine}
A61K51/088 - {conjugates with carriers being peptides, polyamino acids, proteins

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P35/00 - Antineoplastic agents

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/00 - Peptides having more than 20 amino acids
C07K14/4728 - {Calcium binding proteins, e.g. calmodulin}
C07K7/08 - having 12 to 20 amino acids

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DOE Contract Number:: FG03-01ER63276

Resource Type:: Patent

Resource Relation:: Patent File Date: 2011 Jun 07

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Peptides whose uptake by cells is controllable.  United States: N. p., 2015. 
        Web.

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                    Jiang, Tao, Olson, Emilia S., Whitney, Michael, & Tsien, Roger. Peptides whose uptake by cells is controllable.  United States.

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                    Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Tue .  
        "Peptides whose uptake by cells is controllable".  United States.  https://www.osti.gov/servlets/purl/1190922.

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@article{osti_1190922,

  title        = {Peptides whose uptake by cells is controllable},

  author       = {Jiang, Tao and Olson, Emilia S. and Whitney, Michael and Tsien, Roger},

  abstractNote = {A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {7}

}

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