Peptides whose uptake by cells is controllable
A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.
- Issue Date:
- OSTI Identifier:
- The Regents of the University of California (Oakland, CA) OAK
- Patent Number(s):
- Application Number:
- Contract Number:
- Resource Relation:
- Patent File Date: 2011 Jun 07
- Research Org:
- The Regents of the University of California, Oakland, CA (United States)
- Sponsoring Org:
- Country of Publication:
- United States
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES
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Arginine containing peptides as delivery vectors
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- Advanced Drug Delivery Reviews, Vol. 55, Issue 2, p. 281-294
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
journal, November 2000
- Wender, P. A.; Mitchell, D. J.; Pattabiraman, K.
- Proceedings of the National Academy of Sciences, Vol. 97, Issue 24, p. 13003-13008
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