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Title: Peptides whose uptake by cells is controllable

Abstract

A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.

Inventors:
; ; ;
Issue Date:
Research Org.:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1190922
Patent Number(s):
9,072,792
Application Number:
13/155,168
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
FG03-01ER63276
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Jun 07
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Peptides whose uptake by cells is controllable. United States: N. p., 2015. Web.
Jiang, Tao, Olson, Emilia S., Whitney, Michael, & Tsien, Roger. Peptides whose uptake by cells is controllable. United States.
Jiang, Tao, Olson, Emilia S., Whitney, Michael, and Tsien, Roger. Tue . "Peptides whose uptake by cells is controllable". United States. https://www.osti.gov/servlets/purl/1190922.
@article{osti_1190922,
title = {Peptides whose uptake by cells is controllable},
author = {Jiang, Tao and Olson, Emilia S. and Whitney, Michael and Tsien, Roger},
abstractNote = {A generic structure for the peptides of the present invention includes A-X-B-C, where C is a cargo moiety, the B portion includes basic amino acids, X is a cleavable linker sequence, and the A portion includes acidic amino acids. The intact structure is not significantly taken up by cells; however, upon extracellular cleavage of X, the B-C portion is taken up, delivering the cargo to targeted cells. Cargo may be, for example, a contrast agent for diagnostic imaging, a chemotherapeutic drug, or a radiation-sensitizer for therapy. X may be cleaved extracellularly or intracellularly. The molecules of the present invention may be linear, cyclic, branched, or have a mixed structure.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {7}
}

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Works referenced in this record:

Macrocyclic Chelators with Paramagnetic Cations Are Internalized into Mammalian Cells via a HIV-Tat Derived Membrane Translocation Peptide
journal, May 2000

  • Bhorade, Rajeev; Weissleder, Ralph; Nakakoshi, Tsunenori
  • Bioconjugate Chemistry, Vol. 11, Issue 3
  • DOI: 10.1021/bc990168d

Tumor imaging by means of proteolytic activation of cell-penetrating peptides
journal, December 2004

  • Jiang, T.; Olson, E. S.; Nguyen, Q. T.
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 51, p. 17867-17872
  • DOI: 10.1073/pnas.0408191101

Visualizing the mechanical activation of Src
journal, April 2005

  • Wang, Yingxiao; Botvinick, Elliot L.; Zhao, Yihua
  • Nature, Vol. 434, Issue 7036
  • DOI: 10.1038/nature03469

Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation
journal, November 2000

  • Rothbard, Jonathan B.; Garlington, Sarah; Lin, Qun
  • Nature Medicine, Vol. 6, Issue 11
  • DOI: 10.1038/81359

Arginine-Rich Molecular Transporters for Drug Delivery:  Role of Backbone Spacing in Cellular Uptake
journal, August 2002

  • Rothbard, Jonathan B.; Kreider, Erik; VanDeusen, Christopher L.
  • Journal of Medicinal Chemistry, Vol. 45, Issue 17
  • DOI: 10.1021/jm0105676

Arginine containing peptides as delivery vectors
journal, February 2003


The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
journal, November 2000

  • Wender, P. A.; Mitchell, D. J.; Pattabiraman, K.
  • Proceedings of the National Academy of Sciences, Vol. 97, Issue 24, p. 13003-13008
  • DOI: 10.1073/pnas.97.24.13003