DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Biomimetic peptoid polymers

Abstract

The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.

Inventors:
; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1190920
Patent Number(s):
9073977
Application Number:
13/022,548
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Feb 07
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Zuckermann, Ronald N., Chu, Tammy K., and Nam, Ki Tae. Biomimetic peptoid polymers. United States: N. p., 2015. Web.
Zuckermann, Ronald N., Chu, Tammy K., & Nam, Ki Tae. Biomimetic peptoid polymers. United States.
Zuckermann, Ronald N., Chu, Tammy K., and Nam, Ki Tae. Tue . "Biomimetic peptoid polymers". United States. https://www.osti.gov/servlets/purl/1190920.
@article{osti_1190920,
title = {Biomimetic peptoid polymers},
author = {Zuckermann, Ronald N. and Chu, Tammy K. and Nam, Ki Tae},
abstractNote = {The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {7}
}

Works referenced in this record:

Synthesis of N-substituted oligomers
patent, March 1999


Chimeric antisense oligonucleotides and cell transfecting formulations thereof
patent, January 2004


Biological sample component purification and differential display
patent, August 2004


Polypeptoid pulmonary surfactants
patent, May 2005


Fluorogenic dyes
patent, April 2006


Peptoids incorporating chemoselective functionalities
patent, April 2006


Microarrays on mirrored substrates for performing proteomic analyses
patent, December 2006


Peptoids incorporating chemoselective functionalities
patent, August 2008


Oligonucleotide transfection screening method
patent, September 2008


Prion-specific peptoid reagents
patent, November 2010


Polypeptoid pulmonary surfactants
patent, February 2012


Polypeptoid pulmonary surfactants
patent, March 2014


Prion-specific peptoid reagents
patent-application, April 2007


Optical imaging of endometriosis
patent-application, May 2007


Peptoids: a modular approach to drug discovery.
journal, October 1992


NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains
journal, April 1998


Peptoid Oligomers with α-Chiral, Aromatic Side Chains:  Sequence Requirements for the Formation of Stable Peptoid Helices
journal, July 2001


Peptoid Oligomers with α-Chiral, Aromatic Side Chains:  Effects of Chain Length on Secondary Structure
journal, April 2001


Extreme stability of helices formed by water-soluble poly-N-substituted glycines (polypeptoids) with ?-chiral side chains
journal, December 2001


Folding a Nonbiological Polymer into a Compact Multihelical Structure
journal, August 2005


Biomimetic Nanostructures: Creating a High-Affinity Zinc-Binding Site in a Folded Nonbiological Polymer
journal, July 2008


[25] Synthesis of N-substituted glycine peptoid libraries
book, January 1996


Alexa Dyes, a Series of New Fluorescent Dyes that Yield Exceptionally Bright, Photostable Conjugates
journal, September 1999


The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
journal, November 2000