skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Biomimetic peptoid polymers

Abstract

The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.

Inventors:
; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1190920
Patent Number(s):
9073977
Application Number:
13/022,548
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Feb 07
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Zuckermann, Ronald N., Chu, Tammy K., and Nam, Ki Tae. Biomimetic peptoid polymers. United States: N. p., 2015. Web.
Zuckermann, Ronald N., Chu, Tammy K., & Nam, Ki Tae. Biomimetic peptoid polymers. United States.
Zuckermann, Ronald N., Chu, Tammy K., and Nam, Ki Tae. Tue . "Biomimetic peptoid polymers". United States. https://www.osti.gov/servlets/purl/1190920.
@article{osti_1190920,
title = {Biomimetic peptoid polymers},
author = {Zuckermann, Ronald N. and Chu, Tammy K. and Nam, Ki Tae},
abstractNote = {The present invention provides for novel peptoid oligomers that are capable of self-assembling into two-dimensional sheet structures. The peptoid oligomers can have alternately hydrophilic or polar side-chains and hydrophobic or apolar side-chains. The peptoid oligomers, and the two-dimensional sheet structures, can be applied to biological applications where the peptoid plays a role as a biological scaffold or building block. Also, the two-dimensional sheet structures of the present invention can be used as two-dimensional nanostructures in device applications.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {7}
}

Patent:

Save / Share:

Works referenced in this record:

Peptoids: a modular approach to drug discovery.
journal, October 1992


NMR determination of the major solution conformation of a peptoid pentamer with chiral side chains
journal, April 1998


Peptoid Oligomers with α-Chiral, Aromatic Side Chains:  Sequence Requirements for the Formation of Stable Peptoid Helices
journal, July 2001


Peptoid Oligomers with α-Chiral, Aromatic Side Chains:  Effects of Chain Length on Secondary Structure
journal, April 2001


Extreme stability of helices formed by water-soluble poly-N-substituted glycines (polypeptoids) with ?-chiral side chains
journal, December 2001


Folding a Nonbiological Polymer into a Compact Multihelical Structure
journal, August 2005


Biomimetic Nanostructures: Creating a High-Affinity Zinc-Binding Site in a Folded Nonbiological Polymer
journal, July 2008


Alexa Dyes, a Series of New Fluorescent Dyes that Yield Exceptionally Bright, Photostable Conjugates
journal, September 1999


The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
journal, November 2000