Uses of monoclonial antibody 8H9

Cheung, Nai-Kong V.

Title: Uses of monoclonial antibody 8H9

Abstract

This invention provides an antibody that binds the same antigen as that of monoclonal antibody 8H9, wherein the heavy chain CDR (Complementary Determining Region)1 comprises NYDIN, heavy chain CDR2 comprises WIFPGDGSTQY, heavy chain CDR3 comprises QTTATWFAY, and the light chain CDR1 comprises RASQSISDYLH, light chain CDR2 comprises YASQSIS, and light chain CDR3 comprises QNGHSFPLT. In another embodiment, there is provided a polypeptide that binds the same antigen as that of monoclonal antibody 8H9, wherein the polypeptide comprises NYDIN, WIFPGDGSTQY, QTTATWFAY, RASQSISDYLH, YASQSIS, and QNGHSFPLT.

Inventors:: Cheung, Nai-Kong V.

Issue Date:: 2015-06-23

Research Org.:: Sloan-Kettering Inst. for Cancer Research, New York, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1185299

Patent Number(s):: 9062110

Application Number:: 13/858,234

Assignee:: Sloan-Kettering Institute for Cancer Research (New York, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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A - HUMAN NECESSITIES A01 - AGRICULTURE A01K - ANIMAL HUSBANDRY
A01K2217/05 - Animals comprising random inserted nucleic acids

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K2039/505 - {comprising antibodies}
A61K47/6865 - {the tumour determinant being from skin, nerves or brain cancer cell}
A61K47/6873 - {the antibody targeting an immunoglobulin
A61K49/0004 - {Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions}
A61K49/0006 - {Skin tests, e.g. intradermal testing, test strips, delayed hypersensitivity}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K16/00 - Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies {
C07K16/18 - against material from animals or humans
C07K16/28 - against receptors, cell surface antigens or cell surface determinants
C07K16/30 - from tumour cells
C07K16/3053 - {Skin, nerves, brain}
C07K16/4208 - {against an idiotypic determinant on Ig}
C07K16/4266 - {against anti-tumor receptor Ig}
C07K2317/24 - containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K2317/34 - Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
C07K2317/622 - Single chain antibody
C07K2317/732 - Antibody-dependent cellular cytotoxicity [ADCC]
C07K2317/76 - Antagonist effect on antigen, e.g. neutralization or inhibition of binding
C07K2319/00 - Fusion polypeptide

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DOE Contract Number:: FG02-93ER61658

Resource Type:: Patent

Resource Relation:: Patent File Date: 2013 Apr 08

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

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                    Cheung, Nai-Kong V. Uses of monoclonial antibody 8H9.  United States: N. p., 2015. 
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                    Cheung, Nai-Kong V. Uses of monoclonial antibody 8H9.  United States.

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                    Cheung, Nai-Kong V. Tue .  
        "Uses of monoclonial antibody 8H9".  United States.  https://www.osti.gov/servlets/purl/1185299.

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@article{osti_1185299,

  title        = {Uses of monoclonial antibody 8H9},

  author       = {Cheung, Nai-Kong V.},

  abstractNote = {This invention provides an antibody that binds the same antigen as that of monoclonal antibody 8H9, wherein the heavy chain CDR (Complementary Determining Region)1 comprises NYDIN, heavy chain CDR2 comprises WIFPGDGSTQY, heavy chain CDR3 comprises QTTATWFAY, and the light chain CDR1 comprises RASQSISDYLH, light chain CDR2 comprises YASQSIS, and light chain CDR3 comprises QNGHSFPLT. In another embodiment, there is provided a polypeptide that binds the same antigen as that of monoclonal antibody 8H9, wherein the polypeptide comprises NYDIN, WIFPGDGSTQY, QTTATWFAY, RASQSISDYLH, YASQSIS, and QNGHSFPLT.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {6}

}

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Low incidence of molecular evidence for tumour in PBPC harvests from patients with high risk Ewing tumours
journal, August 1999

Fischmeister, G.; Zoubek, A.; Jugovic, D.
Bone Marrow Transplantation, Vol. 24, Issue 4
https://doi.org/10.1038/sj.bmt.1701924

Radiotherapy and High-Dose Chemotherapy in Advanced Ewing's Tumors
journal, October 1999

Pape, Hildegard; Laws, Hans-Jürgen; Burdach, Stefan
Strahlentherapie und Onkologie, Vol. 175, Issue 10
https://doi.org/10.1007/s000660050058

Radioimmunotherapy with alpha-emitting nuclides
journal, September 1998

McDevitt, Michael R.; Sgouros, George; Finn, Ronald D.
European Journal of Nuclear Medicine and Molecular Imaging, Vol. 25, Issue 9
https://doi.org/10.1007/s002590050306

Disialoganglioside GD2 anti-idiotypic monoclonal antibodies
journal, May 1993

Cheung, Nai-Kong V.; Canete, Adela; Cheung, Irene Y.
International Journal of Cancer, Vol. 54, Issue 3
https://doi.org/10.1002/ijc.2910540324

Expression of CD44 splice variants in human primary brain tumors
journal, December 1995

Kaaijk, Patricia; Troost, Dirk; Morsink, Folkert
Journal of Neuro-Oncology, Vol. 26, Issue 3
https://doi.org/10.1007/BF01052621

Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukaemia patients using real-time quantitative RT-PCR: Monitoring of MRD by Real-time Quantitation
journal, August 1998

Menskin,
British Journal of Haematology, Vol. 102, Issue 3
https://doi.org/10.1046/j.1365-2141.1998.00823.x

Phagocytosis of tumor cells by human monocytes cultured in recombinant macrophage colony-stimulating factor
journal, July 1990

Munn, D. H.
Journal of Experimental Medicine, Vol. 172, Issue 1
https://doi.org/10.1084/jem.172.1.231

Anti-idiotypic antibody against FimH adhesion of uropathogenic type I-fimbriated Escherichia coli, compositions containing same and method for using same
patent, October 2003

Wu, Xue
US Patent Document 6,632,431
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6632431

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Abstract

Citation Formats

Detection of (11; 22)(q24;q12) Translocation-Bearing Cells in Peripheral Blood Progenitor Cells of Patients With Ewing's Sarcoma Family of Tumors journal, March 1995

T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients journal, February 1996

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Surface Antigen Expression and Complement Susceptibility of Differentiated Neuroblastoma Clones journal, March 2000

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Desmoplastic Small Round Cell Tumor: II: An Ultrastructural and Immunohistochemical Study with Emphasis on New Immunohistochemical Markers journal, January 1998

Comparison of purity and enrichment of CD34 + cells from bone marrow, umbilical cord and peripheral blood (primed for apheresis) using five separation systems journal, January 1995

Quantitative imaging of I-124 using positron emission tomography with applications to radioimmunodiagnosis and radioimmunotherapy: Quantitative imaging of I-124 journal, May 1991

Intra-abdominal desmoplastic small cell tumor: A light microscopic, immunocytochemical, ultrastructural, and flow cytometric study journal, August 1993

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Characterisation of a new mouse monoclonal antibody (ONS-M21) reactive with both medulloblastomas and gliomas journal, November 1993

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Treatment of recurrent and cystic malignant gliomas by a single intracavity injection of 131I monoclonal antibody: feasibility, pharmacokinetics and dosimetry journal, January 1993

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Phase I studies of treatment of malignant gliomas and neoplastic meningitis with131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab?)2-a preliminary report journal, January 1995

Uses of monoclonal antibody 8H9 patent, April 2013

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Title>Additive cytotoxicity of different monoclonal antibody-cobra venom factor conjugates for human neuroblastoma cells journal, November 1997

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The curability of tumours of differing size by targeted radiotherapy using 131I or 90Y journal, June 1991

Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain journal, July 1993

Detection of (11; 22)(q24;q12) Translocation-Bearing Cells in Peripheral Blood Progenitor Cells of Patients With Ewing's Sarcoma Family of Tumors
journal, March 1995

T–cell mediated rejection of gene–modified HIV–specific cytotoxic T lymphocytes in HIV–infected patients
journal, February 1996

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journal, April 2001

Uses of monoclonal antibody 8H9
patent, August 2013

Surface Antigen Expression and Complement Susceptibility of Differentiated Neuroblastoma Clones
journal, March 2000

SCLC-cluster-2 antibodies detect the pancarcinoma/epithelial glycoprotein EGP-2
journal, January 1994

Expression of 300-kilodalton intermediate filament-associated protein distinguishes human glioma cells from normal astrocytes.
journal, September 1993

Desmoplastic Small Round Cell Tumor: II: An Ultrastructural and Immunohistochemical Study with Emphasis on New Immunohistochemical Markers
journal, January 1998

Comparison of purity and enrichment of CD34 ⁺ cells from bone marrow, umbilical cord and peripheral blood (primed for apheresis) using five separation systems
journal, January 1995

Quantitative imaging of I-124 using positron emission tomography with applications to radioimmunodiagnosis and radioimmunotherapy: Quantitative imaging of I-124
journal, May 1991

Intra-abdominal desmoplastic small cell tumor: A light microscopic, immunocytochemical, ultrastructural, and flow cytometric study
journal, August 1993

Development of a method to measure kinetics of radiolabelled monoclonal antibody in human tumour with applications to microdosimetry: positron emission tomography studies of iodine-124 labelled 3F8 monoclonal antibody in glioma
journal, May 1993

New monoclonal antibodies specific for human sarcomas
journal, July 1986

HSV-TK Gene Transfer into Donor Lymphocytes for Control of Allogeneic Graft-Versus-Leukemia
journal, June 1997

The Diagnostic Utility of Desmin: A Study of 584 Cases and Review of the Literature
journal, March 1990

Ewing Family Tumors: Potential Prognostic Value of Reverse-Transcriptase Polymerase Chain Reaction Detection of Minimal Residual Disease in Peripheral Blood Samples
journal, January 1998

Characterisation of a new mouse monoclonal antibody (ONS-M21) reactive with both medulloblastomas and gliomas
journal, November 1993

Pharmacokinetics of anti-ganglioside GD2 mAb 14G2a in a phase I trial in pediatric cancer patients
journal, January 1995

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journal, November 1986

A potent and specific immunotoxin for tumor cells expressing disialoganglioside GD2
journal, May 1991

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journal, December 1997

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journal, December 1998

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journal, February 2001

Role of High-Dose Chemotherapy With Hematopoietic Stem Cell Rescue in the Treatment of Metastatic or Recurrent Rhabdomyosarcoma
journal, January 2001

Anti-idiotypic antibodies to human melanoma-associated proteoglycan antigen
patent, December 1993

Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes.
journal, March 1994

Phage Library-derived Human Anti-TETA and Anti-DOTA ScFv for Pretargeting RIT
journal, February 1999

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journal, January 1992

Antibody-dependent antitumor cytotoxicity by human monocytes cultured with recombinant macrophage colony-stimulating factor. Induction of efficient antibody-mediated antitumor cytotoxicity not detected by isotope release assays
journal, August 1989

Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics
journal, December 1999

A phase I study of neuroblastoma with the anti-ganglioside GD2 antibody 14.G2a
journal, May 1992

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journal, November 1998

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease
journal, November 1979

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journal, January 1996

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journal, June 1984

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journal, January 1992

Continuous cultures of fused cells secreting antibody of predefined specificity
journal, August 1975

Implementation of a Monte Carlo dosimetry method for patient-specific internal emitter therapy
journal, July 1997

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journal, June 1997

Treatment of recurrent and cystic malignant gliomas by a single intracavity injection of 131I monoclonal antibody: feasibility, pharmacokinetics and dosimetry
journal, January 1993

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journal, November 1998

A Monte Carlo approach to patient-specific dosimetry
journal, September 1996

Humanized immunoglobulins
patent, December 1997

Experimental Tumor Therapy in Mice Using the Cyclophosphamide-Activating Cytochrome P450 2B1 Gene
journal, August 1994

Pharmacokinetics and acute toxicology of intraventricular ¹³¹I-monoclonal antibody targeting disialoganglioside in non-human primates
journal, January 1997

Gene-marking to trace origin of relapse after autologous bone-marrow transplantation
journal, January 1993

Method for preparation of single chain antibodies
patent, April 2012

Biotechnological and gene therapeutic strategies in cancer treatment
journal, June 1995

Clinical Applications of CD34 ⁺ Peripheral Blood Progenitor Cells (PBPC)
journal, March 2000

131I Radioconjugated Antibodies for the Locoregional Radioimmunotherapy of High-grade Malignant Glioma: Phase I and II Study
journal, January 1999

Monoclonal antibody against human glioblastoma multiforme (U-87MG) immunoprecipitates a protein of molecular mass 38 kDa and inhibits tumor growth in nude mice
journal, January 1995

Immunogenic peptides of prostate specific antigen
patent, December 2001

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.
journal, January 1993

Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes
journal, August 1998

Impact of chimeric immune receptor extracellular protein domains on T cell function
journal, March 1999

Demonstration of accuracy and clinical versatility of mutual information for automatic multimodality image fusion using affine and thin-plate spline warped geometric deformations
journal, April 1997

CD34+ selection of autologous peripheral blood stem cells for transplantation following sequential cycles of high-dose therapy and mobilisation in multiple myeloma
journal, June 2000

Autologous stem cell transplantation for high-risk pediatric solid tumors
journal, September 1999

Efficient Discrimination between Different Densities of Target Antigen by Tetracycline-Regulatable T Bodies
journal, March 1999

Superantigen-staphylococal-enterotoxin-A-dependent and antibody-targeted lysis of GD2-positive neuroblastoma cells
journal, March 1995

Yttrium-90 biodistribution by yttrium-87 imaging: A theoretical feasibility analysis
journal, August 1998

Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR
journal, November 1999

Phase I studies of treatment of malignant gliomas and neoplastic meningitis with131I-radiolabeled monoclonal antibodies anti-tenascin 81C6 and anti-chondroitin proteoglycan sulfate Me1-14 F (ab?)2-a preliminary report
journal, January 1995

Uses of monoclonal antibody 8H9
patent, April 2013

Targeting of small-cell lung cancer using the anti-GD2 ganglioside monoclonal antibody 3F8: A pilot trial
journal, February 1996

Radionuclide photon dose kernels for internal emitter dosimetry
journal, May 1996

Multi-stage cascade boosting vaccine
patent, October 2000

Potential of genetically engineered anti-ganglioside GD2 antibodies for cancer immunotherapy
book, January 1994

Decay-accelerating factor protects human tumor cells from complement-mediated cytotoxicity in vitro.
journal, April 1988

Myogenin is a Specific Marker for Rhabdomyosarcoma: An Immunohistochemical Study in Paraffin-Embedded Tissues
journal, September 2000

Title>Additive cytotoxicity of different monoclonal antibody-cobra venom factor conjugates for human neuroblastoma cells
journal, November 1997

Detection of Prostatic Specific Membrane Antigen Messenger RNA Using Immunobead Reverse Transcriptase Polymerase Chain Reaction
journal, January 1999

A phase I study of human/mouse chimeric antiganglioside GD2 antibody ch14.18 in patients with neuroblastoma
journal, January 1995

Hexabrachion Protein (Tenascin, Cytotactin, Brachionectin) in Connective Tissues, Embryonic Brain, and Tumors
journal, January 1988

The EWS-WT1 translocation product induces PDGFA in desmoplastic small round-cell tumour
journal, November 1997

The curability of tumours of differing size by targeted radiotherapy using ¹³¹I or ⁹⁰Y
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Lysis of ovarian cancer cells by human lymphocytes redirected with a chimeric gene composed of an antibody variable region and the Fc receptor gamma chain
journal, July 1993

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journal, October 1999

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journal, July 1999

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journal, August 1999