AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe

Van Berkel, Gary J.

Title: AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe

Abstract

An electrospray system comprises a liquid extraction surface sampling probe. The probe comprises a probe body having a liquid inlet and a liquid outlet, and having a liquid extraction tip. A solvent delivery conduit is provided for receiving solvent liquid from the liquid inlet and delivering the solvent liquid to the liquid extraction tip. An open liquid extraction channel extends across an exterior surface of the probe body from the liquid extraction tip to the liquid outlet. An electrospray emitter tip is in liquid communication with the liquid outlet of the liquid extraction surface sampling probe. A system for analyzing samples, a liquid junction surface sampling system, and a method of analyzing samples are also disclosed.

Inventors:: Van Berkel, Gary J.

Issue Date:: 2015-06-23

Research Org.:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1185288

Patent Number(s):: 9064680

Application Number:: 14/265,912

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS

G - PHYSICS G01 - MEASURING G01Q - SCANNING-PROBE TECHNIQUES OR APPARATUS

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H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/26 - Mass spectrometers or separator tubes
H01J49/0031 - {Step by step routines describing the use of the apparatus

G - PHYSICS G01 - MEASURING G01Q - SCANNING-PROBE TECHNIQUES OR APPARATUS
G01Q30/14 - Liquid environment
G01Q70/08 - Probe characteristics

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/0459 - {for solid samples}

G - PHYSICS G01 - MEASURING G01Q - SCANNING-PROBE TECHNIQUES OR APPARATUS
G01Q60/38 - Probes, their manufacture, or their related instrumentation, e.g. holders

H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
H01J49/167 - {Capillaries and nozzles specially adapted therefor

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DOE Contract Number:: AC05-00OR22725

Resource Type:: Patent

Resource Relation:: Patent File Date: 2014 Apr 30

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION; 36 MATERIALS SCIENCE; 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Van Berkel, Gary J. AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe.  United States: N. p., 2015. 
        Web.

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                    Van Berkel, Gary J. AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe.  United States.

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                    Van Berkel, Gary J. Tue .  
        "AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe".  United States.  https://www.osti.gov/servlets/purl/1185288.

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@article{osti_1185288,

  title        = {AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe},

  author       = {Van Berkel, Gary J.},

  abstractNote = {An electrospray system comprises a liquid extraction surface sampling probe. The probe comprises a probe body having a liquid inlet and a liquid outlet, and having a liquid extraction tip. A solvent delivery conduit is provided for receiving solvent liquid from the liquid inlet and delivering the solvent liquid to the liquid extraction tip. An open liquid extraction channel extends across an exterior surface of the probe body from the liquid extraction tip to the liquid outlet. An electrospray emitter tip is in liquid communication with the liquid outlet of the liquid extraction surface sampling probe. A system for analyzing samples, a liquid junction surface sampling system, and a method of analyzing samples are also disclosed.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {6}

}

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Works referenced in this record:

A micro-nib nanoelectrospray source for mass spectrometry
journal, March 2004

Arscott, S.
Sensors and Actuators B: Chemical, Vol. 98, Issue 2-3
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A nanofluidic emitter tip obtained by focused ion beam nanofabrication
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Arscott, Steve; Troadec, David
Nanotechnology, Vol. 16, Issue 10
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Self-aspirating atmospheric pressure chemical ionization source for direct sampling of analytes on surfaces and in liquid solutions
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Asano, Keiji G.; Ford, Michael J.; Tomkins, Bruce A.
Rapid Communications in Mass Spectrometry, Vol. 19, Issue 16
https://doi.org/10.1002/rcm.2062

Microfluidic design rules for capillary slot-based electrospray sources
journal, September 2004

Brinkmann, M.; Blossey, R.; Arscott, S.
Applied Physics Letters, Vol. 85, Issue 11
https://doi.org/10.1063/1.1792381

Microfluidics in the “Open Space” for Performing Localized Chemistry on Biological Interfaces
journal, October 2012

Kaigala, Govind V.; Lovchik, Robert D.; Delamarche, Emmanuel
Angewandte Chemie International Edition, Vol. 51, Issue 45, p. 11224-11240
https://doi.org/10.1002/anie.201201798

Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry
journal, December 2011

Laskin, Julia; Heath, Brandi S.; Roach, Patrick J.
Analytical Chemistry, Vol. 84, Issue 1
https://doi.org/10.1021/ac2021322

Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry
journal, October 2012

Otsuka, Yoichi; Shide, Sayuri; Naito, Junpei
Rapid Communications in Mass Spectrometry, Vol. 26, Issue 23
https://doi.org/10.1002/rcm.6399

Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry
journal, January 2010

Roach, Patrick J.; Laskin, Julia; Laskin, Alexander
The Analyst, Vol. 135, Issue 9
https://doi.org/10.1039/C0AN00312C

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Title: AFM fluid delivery/liquid extraction surface sampling/electrostatic spray cantilever probe

Abstract

Citation Formats

A micro-nib nanoelectrospray source for mass spectrometry journal, March 2004

A nanofluidic emitter tip obtained by focused ion beam nanofabrication journal, August 2005

Self-aspirating atmospheric pressure chemical ionization source for direct sampling of analytes on surfaces and in liquid solutions journal, January 2005

Microfluidic design rules for capillary slot-based electrospray sources journal, September 2004

Microfluidics in the “Open Space” for Performing Localized Chemistry on Biological Interfaces journal, October 2012

Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry journal, December 2011

Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry journal, October 2012

Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry journal, January 2010

A micro-nib nanoelectrospray source for mass spectrometry
journal, March 2004

A nanofluidic emitter tip obtained by focused ion beam nanofabrication
journal, August 2005

Self-aspirating atmospheric pressure chemical ionization source for direct sampling of analytes on surfaces and in liquid solutions
journal, January 2005

Microfluidic design rules for capillary slot-based electrospray sources
journal, September 2004

Microfluidics in the “Open Space” for Performing Localized Chemistry on Biological Interfaces
journal, October 2012

Tissue Imaging Using Nanospray Desorption Electrospray Ionization Mass Spectrometry
journal, December 2011

Scanning probe electrospray ionization for ambient mass spectrometry: SPESI for ambient mass spectrometry
journal, October 2012

Nanospray desorption electrospray ionization: an ambient method for liquid-extraction surface sampling in mass spectrometry
journal, January 2010