Microfabricated instruments and methods to treat recurrent corneal erosions
Abstract
In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1183466
- Patent Number(s):
- 9,044,299
- Application Number:
- 14/072,370
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN) ORO
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; 36 MATERIALS SCIENCE
Citation Formats
Britton, Jr., Charles L., D'urso, Brian R., Chaum, Edward, Simpson, John T., Baba, Justin S., Ericson, M. Nance, and Warmack, Robert J. Microfabricated instruments and methods to treat recurrent corneal erosions. United States: N. p., 2015.
Web.
Britton, Jr., Charles L., D'urso, Brian R., Chaum, Edward, Simpson, John T., Baba, Justin S., Ericson, M. Nance, & Warmack, Robert J. Microfabricated instruments and methods to treat recurrent corneal erosions. United States.
Britton, Jr., Charles L., D'urso, Brian R., Chaum, Edward, Simpson, John T., Baba, Justin S., Ericson, M. Nance, and Warmack, Robert J. Tue .
"Microfabricated instruments and methods to treat recurrent corneal erosions". United States. https://www.osti.gov/servlets/purl/1183466.
@article{osti_1183466,
title = {Microfabricated instruments and methods to treat recurrent corneal erosions},
author = {Britton, Jr., Charles L. and D'urso, Brian R. and Chaum, Edward and Simpson, John T. and Baba, Justin S. and Ericson, M. Nance and Warmack, Robert J.},
abstractNote = {In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a Bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the Bowman's layer of the eye that are of micro-scale or less. In another embodiment, the present invention provides a method and device for drug delivery. In one embodiment, the device includes an array of glass micro-rods, wherein at least one glass micro-rod of the array of glass micro-rods includes a sharp feature opposite a base of the array of glass micro-rods, wherein the sharp feature includes a treated surface for delivering a chemical compound to the eye.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {6}
}
Works referenced in this record:
Recurrent Corneal Erosion Syndrome
journal, January 2008
- Das, Sujata; Seitz, Berthold
- Survey of Ophthalmology, Vol. 53, Issue 1, p. 3-15