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Title: Preparation of 4-amino-2,4-dioxobutanoic acid

Abstract

A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with sodium ethoxide in ethanol to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl-2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl-2-cyano-3-hydroxybutenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with aqueous sodium hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid.

Inventors:
; ;
Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1183457
Patent Number(s):
9,045,392
Application Number:
13/828,905
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM)
DOE Contract Number:  
AC52-06NA25396
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Unkefer, Pat J., Martinez, Rodolfo A., and Glass, David R. Preparation of 4-amino-2,4-dioxobutanoic acid. United States: N. p., 2015. Web.
Unkefer, Pat J., Martinez, Rodolfo A., & Glass, David R. Preparation of 4-amino-2,4-dioxobutanoic acid. United States.
Unkefer, Pat J., Martinez, Rodolfo A., and Glass, David R. Tue . "Preparation of 4-amino-2,4-dioxobutanoic acid". United States. https://www.osti.gov/servlets/purl/1183457.
@article{osti_1183457,
title = {Preparation of 4-amino-2,4-dioxobutanoic acid},
author = {Unkefer, Pat J. and Martinez, Rodolfo A. and Glass, David R.},
abstractNote = {A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with sodium ethoxide in ethanol to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl-2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl-2-cyano-3-hydroxybutenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with aqueous sodium hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {6}
}

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