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Title: Producing dicarboxylic acids using polyketide synthases

Abstract

The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.

Inventors:
; ;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1182574
Patent Number(s):
9040282
Application Number:
14/038,488
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Katz, Leonard, Fortman, Jeffrey L., and Keasling, Jay D.. Producing dicarboxylic acids using polyketide synthases. United States: N. p., 2015. Web.
Katz, Leonard, Fortman, Jeffrey L., & Keasling, Jay D.. Producing dicarboxylic acids using polyketide synthases. United States.
Katz, Leonard, Fortman, Jeffrey L., and Keasling, Jay D.. Tue . "Producing dicarboxylic acids using polyketide synthases". United States. https://www.osti.gov/servlets/purl/1182574.
@article{osti_1182574,
title = {Producing dicarboxylic acids using polyketide synthases},
author = {Katz, Leonard and Fortman, Jeffrey L. and Keasling, Jay D.},
abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {5}
}

Works referenced in this record:

Recombinant production of novel polyketides
patent, September 1997


Recombinant combinatorial genetic library for the production of novel polyketides
patent, January 1998


Recombinant production of novel polyketides
patent, November 1998


Recombinant production of novel polyketides
patent, December 1998


Recombinant methods and materials for producing epothilones C and D
patent, October 2001


Polyketides and their synthesis
patent, April 2007


A chain initiation factor common to both modular and aromatic polyketide synthases
journal, September 1999


Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
journal, February 2001


Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway
journal, June 2007