Producing dicarboxylic acids using polyketide synthases
The present invention provides for a polyketide synthase (PKS) capable of synthesizing a dicarboxylic acid (diacid). Such diacids include diketide-diacids and triketide-diacids. The invention includes recombinant nucleic acid encoding the PKS, and host cells comprising the PKS. The invention also includes methods for producing the diacids.
- Issue Date:
- OSTI Identifier:
- The Regents of the University of California (Oakland, CA) CHO
- Patent Number(s):
- Application Number:
- Contract Number:
- Research Org:
- Argonne National Lab. (ANL), Argonne, IL (United States)
- Sponsoring Org:
- Country of Publication:
- United States
- 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Other works cited in this record:Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
journal, February 2001
- Heathcote, Michelle L.; Staunton, James; Leadlay, Peter F.
- Chemistry & Biology, Vol. 8, Issue 2, p. 207-220
Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway
journal, June 2007
- Erb, T. J.; Berg, I. A.; Brecht, V.
- Proceedings of the National Academy of Sciences, Vol. 104, Issue 25, p. 10631-10636
Similar records in DOepatents and OSTI.GOV collections: