Bacteriostatic and anti-collagenolytic dental materials through the incorporation of polyacrylic acid modified CuI nanoparticles
Abstract
Provided are antibacterial and antimicrobial surface coatings and dental materials by utilizing the antimicrobial properties of copper chalcogenide and/or copper halide (CuQ, where Q=chalcogens including oxygen, or halogens, or nothing). An antimicrobial barrier is created by incorporation of CuQ nanoparticles of an appropriate size and at a concentration necessary and sufficient to create a unique bioelectrical environment. The unique bioelectrical environment results in biocidal effectiveness through a multi-factorial mechanism comprising a combination of the intrinsic quantum flux of copper (Cu.sup.0, Cu.sup.1+, Cu.sup.2+) ions and the high surface-to-volume electron sink facilitated by the nanoparticle. The result is the constant quantum flux of copper which manifests and establishes the antimicrobial environment preventing or inhibiting the growth of bacteria. The presence of CuQ results in inhibiting or delaying bacterial destruction and endogenous enzymatic breakdown of the zone of resin inter-diffusion, the integrity of which is essential for dental restoration longevity.
- Inventors:
- Issue Date:
- Research Org.:
- MUSC Foundation for Research Development, Charleston, SC (United States); Clemson Univ., SC (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1179803
- Patent Number(s):
- 9034354
- Application Number:
- 13/900,942
- Assignee:
- MUSC Foundation for Research Development (Charleston, SC); Clemson University (Clemson, SC)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61C - DENTISTRY
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- DOE Contract Number:
- FG02-06ER46342
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2013 May 23
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; 36 MATERIALS SCIENCE
Citation Formats
Renne, Walter George, Mennito, Anthony Samuel, Schmidt, Michael Gerard, Vuthiganon, Jompobe, and Chumanov, George. Bacteriostatic and anti-collagenolytic dental materials through the incorporation of polyacrylic acid modified CuI nanoparticles. United States: N. p., 2015.
Web.
Renne, Walter George, Mennito, Anthony Samuel, Schmidt, Michael Gerard, Vuthiganon, Jompobe, & Chumanov, George. Bacteriostatic and anti-collagenolytic dental materials through the incorporation of polyacrylic acid modified CuI nanoparticles. United States.
Renne, Walter George, Mennito, Anthony Samuel, Schmidt, Michael Gerard, Vuthiganon, Jompobe, and Chumanov, George. Tue .
"Bacteriostatic and anti-collagenolytic dental materials through the incorporation of polyacrylic acid modified CuI nanoparticles". United States. https://www.osti.gov/servlets/purl/1179803.
@article{osti_1179803,
title = {Bacteriostatic and anti-collagenolytic dental materials through the incorporation of polyacrylic acid modified CuI nanoparticles},
author = {Renne, Walter George and Mennito, Anthony Samuel and Schmidt, Michael Gerard and Vuthiganon, Jompobe and Chumanov, George},
abstractNote = {Provided are antibacterial and antimicrobial surface coatings and dental materials by utilizing the antimicrobial properties of copper chalcogenide and/or copper halide (CuQ, where Q=chalcogens including oxygen, or halogens, or nothing). An antimicrobial barrier is created by incorporation of CuQ nanoparticles of an appropriate size and at a concentration necessary and sufficient to create a unique bioelectrical environment. The unique bioelectrical environment results in biocidal effectiveness through a multi-factorial mechanism comprising a combination of the intrinsic quantum flux of copper (Cu.sup.0, Cu.sup.1+, Cu.sup.2+) ions and the high surface-to-volume electron sink facilitated by the nanoparticle. The result is the constant quantum flux of copper which manifests and establishes the antimicrobial environment preventing or inhibiting the growth of bacteria. The presence of CuQ results in inhibiting or delaying bacterial destruction and endogenous enzymatic breakdown of the zone of resin inter-diffusion, the integrity of which is essential for dental restoration longevity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {5}
}
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