Multi-modality nanoparticles having optically responsive shape

Chen, Fanqing; Bouchard, Louis-Serge

Title: Multi-modality nanoparticles having optically responsive shape

Abstract

In certain embodiments novel nanoparticles (nanowontons) are provided that are suitable for multimodal imaging and/or therapy. In one embodiment, the nanoparticles include a first biocompatible (e.g., gold) layer, an inner core layer (e.g., a non-biocompatible material), and a biocompatible (e.g., gold) layer. The first gold layer includes a concave surface that forms a first outer surface of the layered nanoparticle. The second gold layer includes a convex surface that forms a second outer surface of the layered nanoparticle. The first and second gold layers encapsulate the inner core material layer. Methods of fabricating such nanoparticles are also provided.

Inventors:: Chen, Fanqing; Bouchard, Louis-Serge

Issue Date:: 2015-05-19

Research Org.:: Argonne National Lab. (ANL), Argonne, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1179791

Patent Number(s):: 9037214

Application Number:: 13/202,976

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

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Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T428/2991 - Coated

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K49/183 - {having a

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S977/902 - Specified use of nanostructure

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K49/1875 - {coated or functionalised with an antibody}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S977/888 - Shaping or removal of materials, e.g. etching

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K49/0002 - {General or multifunctional contrast agents, e.g. chelated agents}
A61K49/225 - {Microparticles, microcapsules
A61K51/1244 - {microparticles or nanoparticles, e.g. polymeric nanoparticles}

B - PERFORMING OPERATIONS B22 - CASTING B22F - WORKING METALLIC POWDER
B22F1/0025 - {Nanofibres or nanotubes}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S977/89 - Deposition of materials, e.g. coating, cvd, or ald

B - PERFORMING OPERATIONS B22 - CASTING B22F - WORKING METALLIC POWDER
B22F2998/00 - Supplementary information concerning processes or compositions relating to powder metallurgy
B22F1/025 - {Metallic coating}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K49/1857 - {the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA}

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
B82Y5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K49/1866 - {the nanoparticle having a

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10S - TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
Y10S977/712 - formed from plural layers of nanosized material, e.g. stacked structures

B - PERFORMING OPERATIONS B22 - CASTING B22F - WORKING METALLIC POWDER
B22F1/0018 - {Nanometer sized particles}

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DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 2010 Feb 23

Country of Publication:: United States

Language:: English

Subject:: 77 NANOSCIENCE AND NANOTECHNOLOGY; 60 APPLIED LIFE SCIENCES; 36 MATERIALS SCIENCE

Citation Formats


                    Chen, Fanqing, and Bouchard, Louis-Serge. Multi-modality nanoparticles having optically responsive shape.  United States: N. p., 2015. 
        Web.

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                    Chen, Fanqing, & Bouchard, Louis-Serge. Multi-modality nanoparticles having optically responsive shape.  United States.

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                    Chen, Fanqing, and Bouchard, Louis-Serge. Tue .  
        "Multi-modality nanoparticles having optically responsive shape".  United States.  https://www.osti.gov/servlets/purl/1179791.

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@article{osti_1179791,

  title        = {Multi-modality nanoparticles having optically responsive shape},

  author       = {Chen, Fanqing and Bouchard, Louis-Serge},

  abstractNote = {In certain embodiments novel nanoparticles (nanowontons) are provided that are suitable for multimodal imaging and/or therapy. In one embodiment, the nanoparticles include a first biocompatible (e.g., gold) layer, an inner core layer (e.g., a non-biocompatible material), and a biocompatible (e.g., gold) layer. The first gold layer includes a concave surface that forms a first outer surface of the layered nanoparticle. The second gold layer includes a convex surface that forms a second outer surface of the layered nanoparticle. The first and second gold layers encapsulate the inner core material layer. Methods of fabricating such nanoparticles are also provided.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {5}

}

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Works referenced in this record:

Gold-coated iron nanoparticles: a novel magnetic resonance agent for T ₁ and T ₂ weighted imaging
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Cho, Sung-Jin; Jarrett, Benjamin R.; Louie, Angelique Y.
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Gold-coated iron nanoparticles for biomedical applications
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Chen, Min; Yamamuro, Saeki; Farrell, Dorothy
Journal of Applied Physics, Vol. 93, Issue 10
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Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Functionalization Strategies
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MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle
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Mulder, Willem J. M.; Strijkers, Gustav J.; Habets, Jo W.
The FASEB Journal, Vol. 19, Issue 14
https://doi.org/10.1096/fj.05-4145fje

Co _core Au _shell nanoparticles: evolution of magnetic properties in the displacement reaction
journal, January 2007

Mandal, Saikat; Krishnan, Kannan M.
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https://doi.org/10.1039/B613371C

Foam-based synthesis of cobalt nanoparticles and their subsequent conversion to CocoreAgshell nanoparticles by a simple transmetallation reaction
journal, January 2004

Bala, Tanushree; Arumugam, Sujatha K.; Pasricha, Renu
Journal of Materials Chemistry, Vol. 14, Issue 6
https://doi.org/10.1039/B315022B

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Similar Records

Title: Multi-modality nanoparticles having optically responsive shape

Abstract

Citation Formats

Gold-coated iron nanoparticles: a novel magnetic resonance agent for T 1 and T 2 weighted imaging journal, January 2006

Gold-coated iron nanoparticles for biomedical applications journal, May 2003

Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Functionalization Strategies journal, October 2008

MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle journal, December 2005

Co core Au shell nanoparticles: evolution of magnetic properties in the displacement reaction journal, January 2007

Foam-based synthesis of cobalt nanoparticles and their subsequent conversion to CocoreAgshell nanoparticles by a simple transmetallation reaction journal, January 2004

Gold-coated iron nanoparticles: a novel magnetic resonance agent for T ₁ and T ₂ weighted imaging
journal, January 2006

Gold-coated iron nanoparticles for biomedical applications
journal, May 2003

Magnetic Iron Oxide Nanoparticles: Synthesis and Surface Functionalization Strategies
journal, October 2008

MR molecular imaging and fluorescence microscopy for identification of activated tumor endothelium using a bimodal lipidic nanoparticle
journal, December 2005

Co _core Au _shell nanoparticles: evolution of magnetic properties in the displacement reaction
journal, January 2007

Foam-based synthesis of cobalt nanoparticles and their subsequent conversion to CocoreAgshell nanoparticles by a simple transmetallation reaction
journal, January 2004