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Title: Engineering microbes for efficient production of chemicals

This present invention relates to production of chemicals from microorganisms that have been genetically engineered and metabolically evolved. Improvements in chemical production have been established, and particular mutations that lead to those improvements have been identified. Specific examples are given in the identification of mutations that occurred during the metabolic evolution of a bacterial strain genetically engineered to produce succinic acid. This present invention also provides a method for evaluating the industrial applicability of mutations that were selected during the metabolic evolution for increased succinic acid production. This present invention further provides microorganisms engineered to have mutations that are selected during metabolic evolution and contribute to improved production of succinic acid, other organic acids and other chemicals of commercial interest.
Inventors:
; ; ; ; ;
Issue Date:
OSTI Identifier:
1178677
Assignee:
Myriant Corporation (Quincy, MA) DOEEE
Patent Number(s):
9,017,976
Application Number:
13/503,999
Contract Number:
EE0002878
Resource Relation:
Patent File Date: 2010 Nov 17
Research Org:
Myriant Corporation, Quincy, MA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 54 ENVIRONMENTAL SCIENCES

Other works cited in this record:

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journal, June 2003
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Role of GldA in dihydroxyacetone and methylglyoxal metabolism of Escherichia coli K12
journal, February 2008

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journal, November 2009
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