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Title: Volume-labeled nanoparticles and methods of preparation

Compositions comprising nanosized objects (i.e., nanoparticles) in which at least one observable marker, such as a radioisotope or fluorophore, is incorporated within the nanosized object. The nanosized objects include, for example, metal or semi-metal oxide (e.g., silica), quantum dot, noble metal, magnetic metal oxide, organic polymer, metal salt, and core-shell nanoparticles, wherein the label is incorporated within the nanoparticle or selectively in a metal oxide shell of a core-shell nanoparticle. Methods of preparing the volume-labeled nanoparticles are also described.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
1178265
Assignee:
UT-Battelle, LLC (Oak Ridge, TN) ORO
Patent Number(s):
9,011,735
Application Number:
12/981,886
Contract Number:
AC05-00OR22725
Resource Relation:
Patent File Date: 2010 Dec 30
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 77 NANOSCIENCE AND NANOTECHNOLOGY; 59 BASIC BIOLOGICAL SCIENCES

Other works cited in this record:

Development of Organic-Dye-Doped Silica Nanoparticles in a Reverse Microemulsion
journal, January 2004
  • Zhao, X.; Bagwe, R. P.; Tan, W.
  • Advanced Materials, Vol. 16, Issue 2, p. 173-176
  • DOI: 10.1002/adma.200305622

Ultrasensitive detection of biomolecules with fluorescent dye-doped nanoparticles
journal, November 2004
  • Lian, Wei; Litherland, Sally A.; Badrane, Hassan
  • Analytical Biochemistry, Vol. 334, Issue 1, p. 135-144
  • DOI: 10.1016/j.ab.2004.08.005

Fluorescent core–shell silica nanoparticles: towards “Lab on a Particle” architectures for nanobiotechnology
journal, September 2006
  • Burns, Andrew; Ow, Hooisweng; Wiesner, Ulrich
  • Chem. Soc. Rev., Vol. 35, Issue 11, p. 1028-1042
  • DOI: 10.1039/B600562B

Quantum dot bioconjugates for imaging, labelling and sensing
journal, June 2005
  • Medintz, Igor L.; Uyeda, H. Tetsuo; Goldman, Ellen R.
  • Nature Materials, Vol. 4, Issue 6, p. 435-446
  • DOI: 10.1038/nmat1390

Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance
journal, November 2003
  • Hirsch, L. R.; Stafford, R. J.; Bankson, J. A.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 23, p. 13549-13554
  • DOI: 10.1073/pnas.2232479100

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