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Title: Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
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Issue Date:
OSTI Identifier:
Los Alamos National Security, LLC (Los Alamos, NM) LANL
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2011 Apr 26
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004

Evolutionary and immunological implications of contemporary HIV-1 variation
journal, September 2001

Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002
  • Gaschen, Brian; Taylor, Jesse; Yusim, Karina
  • Science, Vol. 296, Issue 5577, p. 2354-2360
  • DOI: 10.1126/science.1070441

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus
journal, November 2002
  • Altfeld, Marcus; Allen, Todd M.; Yu, Xu G.
  • Nature, Vol. 420, Issue 6914, p. 434-439
  • DOI: 10.1038/nature01200

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006
  • Fischer, Will; Perkins, Simon; Theiler, James
  • Nature Medicine, Vol. 13, Issue 1, p. 100-106
  • DOI: 10.1038/nm1461

Antigenicity and Immunogenicity of a Synthetic Human Immunodeficiency Virus Type 1 Group M Consensus Envelope Glycoprotein
journal, December 2004

Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity
journal, January 2006

Prospects for an AIDS vaccine
journal, March 2004
  • Desrosiers, Ronald C.
  • Nature Medicine, Vol. 10, Issue 3, p. 221-223
  • DOI: 10.1038/nm0304-221

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010
  • Barouch, Dan H.; O'Brien, Kara L.; Simmons, Nathaniel L.
  • Nature Medicine, Vol. 16, Issue 3, p. 319-323
  • DOI: 10.1038/nm.2089

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination
journal, December 2008
  • Kong, W.-P.; Wu, L.; Wallstrom, T. C.
  • Journal of Virology, Vol. 83, Issue 5, p. 2201-2215
  • DOI: 10.1128/JVI.02256-08

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010
  • Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin
  • Nature Medicine, Vol. 16, Issue 3, p. 324-328
  • DOI: 10.1038/nm.2108

T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces
journal, May 2009
  • Korber, B. T.; Letvin, N. L.; Haynes, B. F.
  • Journal of Virology, Vol. 83, Issue 17, p. 8300-8314
  • DOI: 10.1128/JVI.00114-09

A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys
journal, July 2008
  • Santra, S.; Korber, B. T.; Muldoon, M.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 30, p. 10489-10494
  • DOI: 10.1073/pnas.0803352105