Human immunodeficiency virus type 1 clade M mosaic gag polypeptides

Korber, Bette T; Perkins, Simon; Bhattacharya, Tanmoy; Fischer, William M; Theiler, James; Letvin, Norman; Haynes, Barton F; Hahn, Beatrice H; Yusim, Karina; Kuiken, Carla

Advanced Search OptionsAdvanced Search queries use a traditional Term Search. For more info, see our FAQ.

All Fields:

Patent Title:

Abstract:

Assignee:

Inventor(s):

Patent Number:

Patent Classification (CPC):

All Classifications
A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
B23 - machine tools
B24 - grinding
B25 - hand tools
B26 - hand cutting tools
B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
B29 - working of plastics
B30 - presses
B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
B41 - printing
B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
B65 - conveying
B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
B81 - microstructural technology
B82 - nanotechnology
B99 - subject matter not otherwise provided for in this section
C - chemistry
C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
C03 - glass
C04 - cements
C05 - fertilisers
C06 - explosives
C07 - organic chemistry
C08 - organic macromolecular compounds
C09 - dyes
C10 - petroleum, gas or coke industries
C11 - animal or vegetable oils, fats, fatty substances or waxes
C12 - biochemistry
C13 - sugar industry
C14 - skins
C21 - metallurgy of iron
C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
C40 - combinatorial technology
C99 - subject matter not otherwise provided for in this section
D - textiles
D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
D07 - ropes
D10 - indexing scheme associated with sublasses of section d, relating to textiles
D21 - paper-making
D99 - subject matter not otherwise provided for in this section
E - fixed constructions
E01 - construction of roads, railways, or bridges
E02 - hydraulic engineering
E03 - water supply
E04 - building
E05 - locks
E06 - doors, windows, shutters, or roller blinds in general
E21 - earth drilling
E99 - subject matter not otherwise provided for in this section
F - mechanical engineering
F01 - machines or engines in general
F02 - combustion engines
F03 - machines or engines for liquids
F04 - positive - displacement machines for liquids
F05 - indexing schemes relating to engines or pumps in various subclasses of classes f01-f04
F15 - fluid-pressure actuators
F16 - engineering elements and units
F17 - storing or distributing gases or liquids
F21 - lighting
F22 - steam generation
F23 - combustion apparatus
F24 - heating
F25 - refrigeration or cooling
F26 - drying
F27 - furnaces
F28 - heat exchange in general
F41 - weapons
F42 - ammunition
F99 - subject matter not otherwise provided for in this section
G - physics
G01 - measuring
G02 - optics
G03 - photography
G04 - horology
G05 - controlling
G06 - computing
G07 - checking-devices
G08 - signalling
G09 - education
G10 - musical instruments
G11 - information storage
G12 - instrument details
G16 - information and communication technology [ict] specially adapted for specific application fields
G21 - nuclear physics
G99 - subject matter not otherwise provided for in this section
H - electricity
H01 - basic electric elements
H02 - generation
H03 - basic electronic circuitry
H04 - electric communication technique
H05 - electric techniques not otherwise provided for
H99 - subject matter not otherwise provided for in this section
Y - new / cross sectional technologies
Y02 - technologies or applications for mitigation or adaptation against climate change
Y04 - information or communication technologies having an impact on other technology areas
Y10 - technical subjects covered by former uspc

More Options ...

Title: Human immunodeficiency virus type 1 clade M mosaic gag polypeptides

Abstract

The present invention relates to mosaic HIV-1 group M Gag sequences and to a composition comprising same.

Inventors:: Korber, Bette T; Perkins, Simon; Bhattacharya, Tanmoy; Fischer, William M; Theiler, James; Letvin, Norman; Haynes, Barton F; Hahn, Beatrice H; Yusim, Karina; Kuiken, Carla

Issue Date:: Tue Apr 21 00:00:00 EDT 2015

Research Org.:: Los Alamos National Laboratory (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1178260

Patent Number(s):: 9011875

Application Number:: 13/399,963

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

Show more

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K39/00 - Medicinal preparations containing antigens or antibodies
A61K39/12 - Viral antigens
A61K39/21 - Retroviridae, e.g. equine infectious anemia virus

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P31/18 - for HIV
A61P37/04 - Immunostimulants

C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N2740/16034 - Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Show less

DOE Contract Number:: AC52-06NA25396

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Feb 17

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Korber, Bette T, Perkins, Simon, Bhattacharya, Tanmoy, Fischer, William M, Theiler, James, Letvin, Norman, Haynes, Barton F, Hahn, Beatrice H, Yusim, Karina, and Kuiken, Carla. Human immunodeficiency virus type 1 clade M mosaic gag polypeptides.  United States: N. p., 2015. 
        Web.

Copy to clipboard


                    Korber, Bette T, Perkins, Simon, Bhattacharya, Tanmoy, Fischer, William M, Theiler, James, Letvin, Norman, Haynes, Barton F, Hahn, Beatrice H, Yusim, Karina, & Kuiken, Carla. Human immunodeficiency virus type 1 clade M mosaic gag polypeptides.  United States.

Copy to clipboard


                    Korber, Bette T, Perkins, Simon, Bhattacharya, Tanmoy, Fischer, William M, Theiler, James, Letvin, Norman, Haynes, Barton F, Hahn, Beatrice H, Yusim, Karina, and Kuiken, Carla. Tue .  
        "Human immunodeficiency virus type 1 clade M mosaic gag polypeptides".  United States.  https://www.osti.gov/servlets/purl/1178260.

Copy to clipboard


                    
@article{osti_1178260,

  title        = {Human immunodeficiency virus type 1 clade M mosaic gag polypeptides},

  author       = {Korber, Bette T and Perkins, Simon and Bhattacharya, Tanmoy and Fischer, William M and Theiler, James and Letvin, Norman and Haynes, Barton F and Hahn, Beatrice H and Yusim, Karina and Kuiken, Carla},

  abstractNote = {The present invention relates to mosaic HIV-1 group M Gag sequences and to a composition comprising same.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Apr 21 00:00:00 EDT 2015},

  month        = {Tue Apr 21 00:00:00 EDT 2015}

}

Copy to clipboard

Patent:

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004

Shinoda, Kaori; Xin, Ke-Qin; Jounai, Nao
Vaccine, Vol. 22, Issue 27-28, p. 3676-3690
https://doi.org/10.1016/j.vaccine.2004.03.015

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006

Fischer, Will; Perkins, Simon; Theiler, James
Nature Medicine, Vol. 13, Issue 1, p. 100-106
https://doi.org/10.1038/nm1461

HIV-1 superinfection despite broad CD⁸⁺ T-cell responses containing replication of the primary virus
journal, November 2002

Altfeld, Marcus; Allen, Todd M.; Yu, Xu G.
Nature, Vol. 420, Issue 6914, p. 434-439
https://doi.org/10.1038/nature01200

HIV vaccine strategies
journal, February 2002

Nabel, Gary J.
Vaccine, Vol. 20, Issue 15, p. 1945-1947
https://doi.org/10.1016/S0264-410X(02)00074-9

Evolutionary and immunological implications of contemporary HIV-1 variation
journal, September 2001

Korber, B.
British Medical Bulletin, Vol. 58, Issue 1, p. 19-42
https://doi.org/10.1093/bmb/58.1.19

Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002

Gaschen, Brian; Taylor, Jesse; Yusim, Karina
Science, Vol. 296, Issue 5577, p. 2354-2360
https://doi.org/10.1126/science.1070441

Prospects for an AIDS vaccine
journal, March 2004

Desrosiers, Ronald C.
Nature Medicine, Vol. 10, Issue 3, p. 221-223
https://doi.org/10.1038/nm0304-221

Progress and obstacles in the development of an AIDS vaccine
journal, December 2006

Letvin, Norman L.
Nature Reviews Immunology, Vol. 6, Issue 12
https://doi.org/10.1038/nri1959

The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years
journal, September 2005

Gallo, Robert C.
The Lancet, Vol. 366, Issue 9500, p. 1894-1898
https://doi.org/10.1016/S0140-6736(05)67395-3

HIV VACCINES
journal, December 2005

McMichael, Andrew J.
Annual Review of Immunology, Vol. 24, Issue 1, p. 227-255
https://doi.org/10.1146/annurev.immunol.24.021605.090605

Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity
journal, January 2006

Peng, Bo; Voltan, Rebecca; Cristillo, Anthony D.
AIDS, Vol. 20, Issue 17, p. 2149-2157
https://doi.org/10.1097/QAD.0b013e32801086ee

Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
journal, January 2014

Haynes, Barton F.; Montefiori, David C.
Expert Review of Vaccines, Vol. 5, Issue 3, p. 347-363
https://doi.org/10.1586/14760584.5.3.347

Toward an AIDS Vaccine
journal, May 2008

Walker, Bruce D.; Burton, Dennis R.
Science, Vol. 320, Issue 5877, p. 760-764
https://doi.org/10.1126/science.1152622

Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope
journal, August 2005

Doria-Rose, N. A.; Learn, G. H.; Rodrigo, A. G.
Journal of Virology, Vol. 79, Issue 17, p. 11214-11224
https://doi.org/10.1128/JVI.79.17.11214-11224.2005

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice
journal, February 1998

Hanke, Tomas; Schneider, Jorg; Gilbert, Sarah C.
Vaccine, Vol. 16, Issue 4, p. 426-435
https://doi.org/10.1016/S0264-410X(97)00296-X

Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
journal, October 2008

Tomaras, G. D.; Yates, N. L.; Liu, P.
Journal of Virology, Vol. 82, Issue 24, p. 12449-12463
https://doi.org/10.1128/JVI.01708-08

Cross-Subtype T-Cell Immune Responses Induced by a Human Immunodeficiency Virus Type 1 Group M Consensus Env Immunogen
journal, June 2006

Weaver, E. A.; Lu, Z.; Camacho, Z. T.
Journal of Virology, Vol. 80, Issue 14, p. 6745-6756
https://doi.org/10.1128/JVI.02484-05

A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses
journal, September 2006

Liao, Hua-Xin; Sutherland, Laura L.; Xia, Shi-Mao
Virology, Vol. 353, Issue 2, p. 268-282
https://doi.org/10.1016/j.virol.2006.04.043

Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins
journal, September 2009

Go, Eden P.; Chang, Qing; Liao, Hua-Xin
Journal of Proteome Research, Vol. 8, Issue 9, p. 4231-4242
https://doi.org/10.1021/pr9002728

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010

Barouch, Dan H.; O'Brien, Kara L.; Simmons, Nathaniel L.
Nature Medicine, Vol. 16, Issue 3, p. 319-323
https://doi.org/10.1038/nm.2089

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination
journal, December 2008

Kong, W.-P.; Wu, L.; Wallstrom, T. C.
Journal of Virology, Vol. 83, Issue 5, p. 2201-2215
https://doi.org/10.1128/JVI.02256-08

Mosaic vaccines elicit CD8⁺ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010

Santra, Sampa; Liao, Hua-Xin; Zhang, Ruijin
Nature Medicine, Vol. 16, Issue 3, p. 324-328
https://doi.org/10.1038/nm.2108

T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces
journal, May 2009

Korber, B. T.; Letvin, N. L.; Haynes, B. F.
Journal of Virology, Vol. 83, Issue 17, p. 8300-8314
https://doi.org/10.1128/JVI.00114-09

A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys
journal, July 2008

Santra, S.; Korber, B. T.; Muldoon, M.
Proceedings of the National Academy of Sciences, Vol. 105, Issue 30, p. 10489-10494
https://doi.org/10.1073/pnas.0803352105

Ancestral and COT viral sequences, proteins and immunogenic compositions
patent, February 2010

Mullins, James; Rodrigo, Allen; Learn, Gerald
US Patent Document 7,655,774
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7655774

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
patent, May 2011

Korber, Bette T.; Fischer, William M.; Liao, Hua-Xin
US Patent Document 7,951,377
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7951377

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins
patent, February 2012

Korber, Bette T.; Perkins, Simon; Bhattacharya, Tanmoy
US Patent Document 8,119,140
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8119140

Antigen Library Immunization
patent-application, December 2002

Punnonen, Juha; Bass, Steven H.; Whalen, Robert Gerald
US Patent Document 09/247890; 20020198162
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20020198162

Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications
patent-application, March 2003

Emini, Emilio A.; Youil, Rima; Bett, Andrew J.
US Patent Document 09/952060; 20030044421
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030044421

Method for the development of an HIV vaccine
patent-application, June 2003

Rios, Adan
US Patent Document 10/331685; 20030104011
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030104011

Polyvalent immunogen
patent-application, August 2003

Haynes, Barton F.; Korber, Bette T.; De Lorimier, Robert M.
US Patent Document 10/289228; 20030147888
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030147888

Immunogenic, cross-clade, HIV peptides
patent-application, September 2003

DeGroot, Anne
US Patent Document 10/200708; 20030180314
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030180314

Peptide compositions for the treatment and prevention of HIV infection
patent-application, October 2003

Rubinstein, Arye; Bloom, Barry R.; Devash, Yair
US Patent Document 10/213742; 20030194411
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20030194411

Polyvalent immunogen
patent-application, January 2004

Haynes, Barton F.; Korber, Bette T.; De Lorimier, Robert M.
US Patent Document 10/373592; 20040001851
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040001851

Ancestral and COT viral sequences, proteins and immunogenic compositions
patent-application, June 2005

Mullins, James I.; Rodrigo, Allen G.; Learn, Gerald H.
US Patent Document 10/780507; 20050137387
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20050137387

Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use
patent-application, September 2006

Lal, Renu B.; Owen, Sherry M.
US Patent Document 10/550651; 20060216305
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060216305

HIV vaccines based on Env of multiple clades of HIV
patent-application, December 2006

Nabel, Gary J.; Chakrabarti, Bimal; Kong, Wing-pui
US Patent Application 11/376484; 20060275897
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20060275897

Consensus/ancestral immunogens
patent-application, August 2007

Haynes, Barton; Gao, Feng; Korber, Bette
US Patent Application 10/572638; 20070178562
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20070178562

Polyvalent Vaccine
patent-application, December 2009

Korber, Bette T.; Perkins, Simon; Bhattacharya, Tanmoy
US Patent Document 11/990222; 20090324631
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20090324631

Polyvalent Vaccine
patent-application, June 2011

Korber, Bette; Perkins, Simon; Bhattacharya, Tanmoy
US Patent Application 12/960287; 20110150915
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20110150915

Polyvalent Vaccine
patent-application, May 2012

Korber, Bette; Fischer, William; Letvin, Norman
US Patent Application 12/737761; 20120121631
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20120121631

Similar Records in DOE Patents and OSTI.GOV collections:

Nucleic acids encoding mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

Patent Korber, Bette T; Fischer, William; Liao, Hua-Xin; ...

The present invention relates to nucleic acids encoding mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
Full Text Available
Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens

Patent Korber, Bette T. [Los Alamos, NM]; Fischer, William [Los Alamos, NM]; Liao, Hua-Xin [Durham, NC]; ...

The present invention relates to mosaic clade M HIV-1 Env polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
Full Text Available
Human Immunodeficiency Virus type 1 group M consensus and mosaic envelope glycoproteins

Patent Korber, Bette T.; Fischer, William; Liao, Hua-Xin; ...

The disclosure relates to nucleic acids mosaic clade M HIV-1 Env polypeptides and to compositions and vectors comprising same. The nucleic acids are suitable for use in inducing an immune response to HIV-1 in a human.
Full Text Available
Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins

Patent Haynes, Barton F [Durham, NC]; Gao, Feng [Durham, NC]; Korber, Bette T [Los Alamos, NM]; ...

The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
Full Text Available
Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins

Patent Korber, Bette T [Los Alamos, NM]; Perkins, Simon [Los Alamos, NM]; Bhattacharya, Tanmoy [Los Alamos, NM]; ...

The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human.
Full Text Available

Similar Records

Title: Human immunodeficiency virus type 1 clade M mosaic gag polypeptides

Abstract

Citation Formats

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice journal, September 2004

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants journal, December 2006

HIV-1 superinfection despite broad CD8+ T-cell responses containing replication of the primary virus journal, November 2002

HIV vaccine strategies journal, February 2002

Evolutionary and immunological implications of contemporary HIV-1 variation journal, September 2001

Diversity Considerations in HIV-1 Vaccine Selection journal, June 2002

Prospects for an AIDS vaccine journal, March 2004

Progress and obstacles in the development of an AIDS vaccine journal, December 2006

The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years journal, September 2005

HIV VACCINES journal, December 2005

Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity journal, January 2006

Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates journal, January 2014

Toward an AIDS Vaccine journal, May 2008

Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope journal, August 2005

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice journal, February 1998

Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia journal, October 2008

Cross-Subtype T-Cell Immune Responses Induced by a Human Immunodeficiency Virus Type 1 Group M Consensus Env Immunogen journal, June 2006

A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses journal, September 2006

Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins journal, September 2009

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys journal, February 2010

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination journal, December 2008

Mosaic vaccines elicit CD8+ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys journal, February 2010

T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces journal, May 2009

A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys journal, July 2008

Ancestral and COT viral sequences, proteins and immunogenic compositions patent, February 2010

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens patent, May 2011

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins patent, February 2012

Antigen Library Immunization patent-application, December 2002

Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications patent-application, March 2003

Method for the development of an HIV vaccine patent-application, June 2003

Polyvalent immunogen patent-application, August 2003

Immunogenic, cross-clade, HIV peptides patent-application, September 2003

Peptide compositions for the treatment and prevention of HIV infection patent-application, October 2003

Polyvalent immunogen patent-application, January 2004

Ancestral and COT viral sequences, proteins and immunogenic compositions patent-application, June 2005

Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use patent-application, September 2006

HIV vaccines based on Env of multiple clades of HIV patent-application, December 2006

Consensus/ancestral immunogens patent-application, August 2007

Polyvalent Vaccine patent-application, December 2009

Polyvalent Vaccine patent-application, June 2011

Polyvalent Vaccine patent-application, May 2012

Polygene DNA vaccine induces a high level of protective effect against HIV-vaccinia virus challenge in mice
journal, September 2004

Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants
journal, December 2006

HIV-1 superinfection despite broad CD⁸⁺ T-cell responses containing replication of the primary virus
journal, November 2002

HIV vaccine strategies
journal, February 2002

Evolutionary and immunological implications of contemporary HIV-1 variation
journal, September 2001

Diversity Considerations in HIV-1 Vaccine Selection
journal, June 2002

Prospects for an AIDS vaccine
journal, March 2004

Progress and obstacles in the development of an AIDS vaccine
journal, December 2006

The end or the beginning of the drive to an HIV-preventive vaccine: a view from over 20 years
journal, September 2005

HIV VACCINES
journal, December 2005

Replicating Ad-recombinants encoding non-myristoylated rather than wild-type HIV Nef elicit enhanced cellular immunity
journal, January 2006

Aiming to induce broadly reactive neutralizing antibody responses with HIV-1 vaccine candidates
journal, January 2014

Toward an AIDS Vaccine
journal, May 2008

Human Immunodeficiency Virus Type 1 Subtype B Ancestral Envelope Protein Is Functional and Elicits Neutralizing Antibodies in Rabbits Similar to Those Elicited by a Circulating Subtype B Envelope
journal, August 2005

DNA multi-CTL epitope vaccines for HIV and Plasmodium falciparum: immunogenicity in mice
journal, February 1998

Initial B-Cell Responses to Transmitted Human Immunodeficiency Virus Type 1: Virion-Binding Immunoglobulin M (IgM) and IgG Antibodies Followed by Plasma Anti-gp41 Antibodies with Ineffective Control of Initial Viremia
journal, October 2008

Cross-Subtype T-Cell Immune Responses Induced by a Human Immunodeficiency Virus Type 1 Group M Consensus Env Immunogen
journal, June 2006

A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses
journal, September 2006

Glycosylation Site-Specific Analysis of Clade C HIV-1 Envelope Proteins
journal, September 2009

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys
journal, February 2010

Expanded Breadth of the T-Cell Response to Mosaic Human Immunodeficiency Virus Type 1 Envelope DNA Vaccination
journal, December 2008

Mosaic vaccines elicit CD8⁺ T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys
journal, February 2010

T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces
journal, May 2009

A centralized gene-based HIV-1 vaccine elicits broad cross-clade cellular immune responses in rhesus monkeys
journal, July 2008

Ancestral and COT viral sequences, proteins and immunogenic compositions
patent, February 2010

Mosaic clade M human immunodeficiency virus type 1 (HIV-1) envelope immunogens
patent, May 2011

Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins
patent, February 2012

Antigen Library Immunization
patent-application, December 2002

Enhanced first generation adenovirus vaccines expressing codon optimized HIV1-Gag, Pol, Nef and modifications
patent-application, March 2003

Method for the development of an HIV vaccine
patent-application, June 2003

Polyvalent immunogen
patent-application, August 2003

Immunogenic, cross-clade, HIV peptides
patent-application, September 2003

Peptide compositions for the treatment and prevention of HIV infection
patent-application, October 2003

Polyvalent immunogen
patent-application, January 2004

Ancestral and COT viral sequences, proteins and immunogenic compositions
patent-application, June 2005

Immunogenic hiv-1 multi-clade, multivalent constructs and methods of their use
patent-application, September 2006

HIV vaccines based on Env of multiple clades of HIV
patent-application, December 2006

Consensus/ancestral immunogens
patent-application, August 2007

Polyvalent Vaccine
patent-application, December 2009

Polyvalent Vaccine
patent-application, June 2011

Polyvalent Vaccine
patent-application, May 2012