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Title: Rapid detection and identification of energetic materials with surface enhanced raman spectrometry (SERS)

Abstract

In one embodiment, a system includes a plurality of metal nanoparticles functionalized with a plurality of organic molecules tethered thereto, wherein the plurality of organic molecules preferentially interact with one or more analytes when placed in proximity therewith. According to another embodiment, a method for detecting analytes includes contacting a fluid having one or more analytes of interest therein with a plurality of metal nanoparticles, each metal nanoparticle having a plurality of organic molecules tethered thereto, and detecting Raman scattering from an analyte of interest from the fluid, the analyte interacting with one or more of the plurality of organic molecules. In another embodiment, a method includes chemically modifying a plurality of cyclodextrin molecules at a primary hydroxyl moiety to create a chemical handle, and tethering the plurality of cyclodextrin molecules to a metal nanoparticle using the chemical handle. Other systems and methods for detecting analytes are also described.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1178253
Patent Number(s):
9012241
Application Number:
12/844,778
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Jul 27
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Han, Thomas Yong-Jin, Valdez, Carlos A, Olson, Tammy Y, Kim, Sung Ho, and Satcher, Jr., Joe H. Rapid detection and identification of energetic materials with surface enhanced raman spectrometry (SERS). United States: N. p., 2015. Web.
Han, Thomas Yong-Jin, Valdez, Carlos A, Olson, Tammy Y, Kim, Sung Ho, & Satcher, Jr., Joe H. Rapid detection and identification of energetic materials with surface enhanced raman spectrometry (SERS). United States.
Han, Thomas Yong-Jin, Valdez, Carlos A, Olson, Tammy Y, Kim, Sung Ho, and Satcher, Jr., Joe H. Tue . "Rapid detection and identification of energetic materials with surface enhanced raman spectrometry (SERS)". United States. https://www.osti.gov/servlets/purl/1178253.
@article{osti_1178253,
title = {Rapid detection and identification of energetic materials with surface enhanced raman spectrometry (SERS)},
author = {Han, Thomas Yong-Jin and Valdez, Carlos A and Olson, Tammy Y and Kim, Sung Ho and Satcher, Jr., Joe H},
abstractNote = {In one embodiment, a system includes a plurality of metal nanoparticles functionalized with a plurality of organic molecules tethered thereto, wherein the plurality of organic molecules preferentially interact with one or more analytes when placed in proximity therewith. According to another embodiment, a method for detecting analytes includes contacting a fluid having one or more analytes of interest therein with a plurality of metal nanoparticles, each metal nanoparticle having a plurality of organic molecules tethered thereto, and detecting Raman scattering from an analyte of interest from the fluid, the analyte interacting with one or more of the plurality of organic molecules. In another embodiment, a method includes chemically modifying a plurality of cyclodextrin molecules at a primary hydroxyl moiety to create a chemical handle, and tethering the plurality of cyclodextrin molecules to a metal nanoparticle using the chemical handle. Other systems and methods for detecting analytes are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {4}
}

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