Devices, systems, and methods for microscale isoelectric fractionation

Sommer, Gregory J; Hatch, Anson V; Wang, Ying-Chih; Singh, Anup K

Title: Devices, systems, and methods for microscale isoelectric fractionation

Abstract

Embodiments of the present invention provide devices, systems, and methods for microscale isoelectric fractionation. Analytes in a sample may be isolated according to their isoelectric point within a fractionation microchannel. A microfluidic device according to an embodiment of the invention includes a substrate at least partially defining a fractionation microchannel. The fractionation microchannel has at least one cross-sectional dimension equal to or less than 1 mm. A plurality of membranes of different pHs are disposed in the microchannel. Analytes having an isoelectric point between the pH of the membranes may be collected in a region of the fractionation channel between the first and second membranes through isoelectric fractionation.

Inventors:: Sommer, Gregory J; Hatch, Anson V; Wang, Ying-Chih; Singh, Anup K

Issue Date:: Tue Apr 14 00:00:00 EDT 2015

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1178015

Patent Number(s):: 9005417

Application Number:: 12/243,817

Assignee:: Sandia Corporation (Albuquerque, NM)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B29 - WORKING OF PLASTICS B29D - PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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B - PERFORMING OPERATIONS B29 - WORKING OF PLASTICS B29D - PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
B29D7/01 - Films or sheets

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N27/4473 - {by electric means}
G01N27/44791 - {Microapparatus
G01N27/44795 - {Isoelectric focusing}

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DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2008 Oct 01

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Sommer, Gregory J, Hatch, Anson V, Wang, Ying-Chih, and Singh, Anup K. Devices, systems, and methods for microscale isoelectric fractionation.  United States: N. p., 2015. 
        Web.

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                    Sommer, Gregory J, Hatch, Anson V, Wang, Ying-Chih, & Singh, Anup K. Devices, systems, and methods for microscale isoelectric fractionation.  United States.

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                    Sommer, Gregory J, Hatch, Anson V, Wang, Ying-Chih, and Singh, Anup K. Tue .  
        "Devices, systems, and methods for microscale isoelectric fractionation".  United States.  https://www.osti.gov/servlets/purl/1178015.

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@article{osti_1178015,

  title        = {Devices, systems, and methods for microscale isoelectric fractionation},

  author       = {Sommer, Gregory J and Hatch, Anson V and Wang, Ying-Chih and Singh, Anup K},

  abstractNote = {Embodiments of the present invention provide devices, systems, and methods for microscale isoelectric fractionation. Analytes in a sample may be isolated according to their isoelectric point within a fractionation microchannel. A microfluidic device according to an embodiment of the invention includes a substrate at least partially defining a fractionation microchannel. The fractionation microchannel has at least one cross-sectional dimension equal to or less than 1 mm. A plurality of membranes of different pHs are disposed in the microchannel. Analytes having an isoelectric point between the pH of the membranes may be collected in a region of the fractionation channel between the first and second membranes through isoelectric fractionation.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Apr 14 00:00:00 EDT 2015},

  month        = {Tue Apr 14 00:00:00 EDT 2015}

}

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Title: Devices, systems, and methods for microscale isoelectric fractionation

Abstract

Citation Formats

Axial Bearing patent, March 1966

Rotatable Finned Heat Transfer Device patent, October 1974

Separation of solid and liquid components of mixtures patent, November 1978

Apparatus and method for measuring white blood cell and platelet concentrations in blood patent, May 1979

Compact miniature fan patent, August 1979

Reversible drive circuit for brushless DC motor patent, August 1981

Gas-lubricated bearings patent, April 1983

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device patent, November 1985

Method and apparatus for measuring blood constituent counts patent, July 1987

Dynamic heat sink patent, March 1991

Thermal control variable speed DC brushless fan patent, March 1993

Method of separation employing magnetic particles and second medium patent, January 1994

Cooling microfan arrangements and process patent, March 1994

Heat exchange apparatus and method for preparing the apparatus patent, March 1994

Disk augmented heat transfer system patent, August 1994

Heat sink assembly for a central processing unit of a computer patent, December 1996

Fan motor patent, April 1997

Assay of blood or other biologic samples for target analytes patent, June 1997

Fan speed monitoring system for determining the speed of a PWM fan patent, March 1998

Transistor package structured to provide heat dissipation enabling use of silicon carbide transistors and other high power semiconductor devices patent, April 1998

Forced air cooling apparatus for semiconductor chips patent, August 1998

Heat sink apparatus patent, September 1999

Apparatus for optimizing the rotational speed of cooling fans patent, October 1999

Cooling fan and cooling fan assembly patent, November 1999

Method and apparatus for cooling an electronic device patent, April 2000

Data storage and/or retrieval methods and apparatuses and components thereof patent, June 2000

Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex patent, November 2000

Heat transfer apparatus patent, January 2001

Fan with magnetic blades patent, February 2001

Rotor drive motor with u-shaped stator cores patent, June 2001

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system patent, November 2001

CPU fan assembly patent, March 2002

Microfluidic systems patent, April 2002

Substrate structure of a liquid crystal display and a manufacturing method thereof patent, May 2002

Composite heat dissipation fan patent, October 2002

Circuit board fixing structure of heatsink fan patent, February 2003

Cooling module and related control circuits useful therefor incorporating a communication port for receiving digital command signals to control module patent, April 2003

Cooling apparatus for cooling electric element patent, September 2003

Multilevel flow structures patent, September 2003

Method and device for separation of charged molecules by solution isoelectric focusing patent, October 2003

Cooler for electronic devices patent, December 2003

Cooler for electronic devices patent, December 2003

Methods for forming small-volume electrical contacts and material manipulations with fluidic microchannels patent, February 2004

Radiator fan patent, March 2005

Very thin fan motor with attached heat sink patent, March 2005

Active heat sink for high power microprocessors patent, April 2005

Speed control circuit of brushless DC fan motor patent, April 2005

Hybrid cooling system and method for cooling electronic devices patent, October 2005

Class characterization of circulating cancer cells isolated from body fluids and methods of use patent, November 2005

Venturi fan patent, November 2005

Apparatus for cooling of electronic components patent, April 2006

Multi-parameter assays including analysis discs and methods relating thereto patent, April 2006

Apparatus for air cooling of an electronic device patent, April 2006

Cooler for electronic devices patent, May 2006

Impeller driven active heat sink patent, June 2006

Integrated cooler for electronic devices patent, July 2006

Integrated liquid cooling system for electrical components patent, September 2006

Radial-flow heat-dissipating fan with increased inlet airflow patent, November 2006

Wave-fans and wave-fans with heat sinks patent, November 2006

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto patent, January 2007

Integrated liquid cooling device with immersed electronic components patent, January 2007

Fan device for removing heat from heat sources patent, January 2007

CPU heat dissipating device structure patent, September 2007

Heat-dissipating device patent, September 2007

Cooling apparatus for heat generating devices patent, September 2007

Heatsink assembly and method of manufacturing the same patent, October 2007

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Microfluidic particle-analysis systems patent, December 2007

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Axial Bearing
patent, March 1966

Rotatable Finned Heat Transfer Device
patent, October 1974

Separation of solid and liquid components of mixtures
patent, November 1978

Apparatus and method for measuring white blood cell and platelet concentrations in blood
patent, May 1979

Compact miniature fan
patent, August 1979

Reversible drive circuit for brushless DC motor
patent, August 1981

Gas-lubricated bearings
patent, April 1983

Pre-column for preconcentrating substances to be chromatographed as well as device for a liquid chromatography system and coupling member for said device
patent, November 1985

Method and apparatus for measuring blood constituent counts
patent, July 1987

Dynamic heat sink
patent, March 1991

Thermal control variable speed DC brushless fan
patent, March 1993

Method of separation employing magnetic particles and second medium
patent, January 1994

Cooling microfan arrangements and process
patent, March 1994

Heat exchange apparatus and method for preparing the apparatus
patent, March 1994

Disk augmented heat transfer system
patent, August 1994

Heat sink assembly for a central processing unit of a computer
patent, December 1996

Fan motor
patent, April 1997

Assay of blood or other biologic samples for target analytes
patent, June 1997

Fan speed monitoring system for determining the speed of a PWM fan
patent, March 1998

Transistor package structured to provide heat dissipation enabling use of silicon carbide transistors and other high power semiconductor devices
patent, April 1998

Forced air cooling apparatus for semiconductor chips
patent, August 1998

Heat sink apparatus
patent, September 1999

Apparatus for optimizing the rotational speed of cooling fans
patent, October 1999

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patent, November 1999

Method and apparatus for cooling an electronic device
patent, April 2000

Data storage and/or retrieval methods and apparatuses and components thereof
patent, June 2000

Crystallizable compositions comprising a hepatitis C virus NS3 protease domain/NS4A complex
patent, November 2000

Heat transfer apparatus
patent, January 2001

Fan with magnetic blades
patent, February 2001

Rotor drive motor with u-shaped stator cores
patent, June 2001

Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
patent, November 2001

CPU fan assembly
patent, March 2002

Microfluidic systems
patent, April 2002

Substrate structure of a liquid crystal display and a manufacturing method thereof
patent, May 2002

Composite heat dissipation fan
patent, October 2002

Circuit board fixing structure of heatsink fan
patent, February 2003

Cooling module and related control circuits useful therefor incorporating a communication port for receiving digital command signals to control module
patent, April 2003

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patent, September 2003

Multilevel flow structures
patent, September 2003

Method and device for separation of charged molecules by solution isoelectric focusing
patent, October 2003

Cooler for electronic devices
patent, December 2003

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patent, December 2003

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patent, February 2004

Radiator fan
patent, March 2005

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patent, March 2005

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patent, April 2005

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patent, April 2005

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patent, October 2005

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patent, November 2005

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patent, November 2005

Apparatus for cooling of electronic components
patent, April 2006

Multi-parameter assays including analysis discs and methods relating thereto
patent, April 2006

Apparatus for air cooling of an electronic device
patent, April 2006

Cooler for electronic devices
patent, May 2006

Impeller driven active heat sink
patent, June 2006

Integrated cooler for electronic devices
patent, July 2006

Integrated liquid cooling system for electrical components
patent, September 2006

Radial-flow heat-dissipating fan with increased inlet airflow
patent, November 2006

Wave-fans and wave-fans with heat sinks
patent, November 2006

Optical bio-discs and fluidic circuits for analysis of cells and methods relating thereto
patent, January 2007

Integrated liquid cooling device with immersed electronic components
patent, January 2007

Fan device for removing heat from heat sources
patent, January 2007

CPU heat dissipating device structure
patent, September 2007

Heat-dissipating device
patent, September 2007

Cooling apparatus for heat generating devices
patent, September 2007

Heatsink assembly and method of manufacturing the same
patent, October 2007

Heat-receiving apparatus and electronic equipment
patent, November 2007

Heat sink assembly
patent, December 2007

Microfluidic particle-analysis systems
patent, December 2007

Dual impeller push-pull axial fan heat sink
patent, January 2008

Heat dissipation device
patent, March 2008

Fan motor
patent, June 2008

Portable apparatus for separating sample and detecting target analytes
patent, November 2008

Miniature blower fan
patent, November 2008

Semiconductor chip heat transfer device
patent, December 2008

Cooling apparatus
patent, January 2009

Heat dissipation apparatus
patent, April 2009

Systems for integrated pump and reservoir
patent, June 2009

Pump structures integral to a fluid filled heat transfer apparatus
patent, February 2010

Heat dissipating module
patent, March 2010