skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Multi-analyte analysis of saliva biomarkers as predictors of periodontal and pre-implant disease

Abstract

The present invention relates to methods of measuring biomarkers to determine the probability of a periodontal and/or peri-implant disease. More specifically, the invention provides a panel of biomarkers that, when used in combination, can allow determination of the probability of a periodontal and/or peri-implant disease state with extremely high accuracy.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-CA), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1177499
Patent Number(s):
9002654
Application Number:
12/670,072
Assignee:
The Regents of the University of Michigan (Ann Arbor, MI)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02A - TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Jul 30
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Braun, Thomas, Giannobile, William V, Herr, Amy E, Singh, Anup K, and Shelburne, Charlie. Multi-analyte analysis of saliva biomarkers as predictors of periodontal and pre-implant disease. United States: N. p., 2015. Web.
Braun, Thomas, Giannobile, William V, Herr, Amy E, Singh, Anup K, & Shelburne, Charlie. Multi-analyte analysis of saliva biomarkers as predictors of periodontal and pre-implant disease. United States.
Braun, Thomas, Giannobile, William V, Herr, Amy E, Singh, Anup K, and Shelburne, Charlie. Tue . "Multi-analyte analysis of saliva biomarkers as predictors of periodontal and pre-implant disease". United States. https://www.osti.gov/servlets/purl/1177499.
@article{osti_1177499,
title = {Multi-analyte analysis of saliva biomarkers as predictors of periodontal and pre-implant disease},
author = {Braun, Thomas and Giannobile, William V and Herr, Amy E and Singh, Anup K and Shelburne, Charlie},
abstractNote = {The present invention relates to methods of measuring biomarkers to determine the probability of a periodontal and/or peri-implant disease. More specifically, the invention provides a panel of biomarkers that, when used in combination, can allow determination of the probability of a periodontal and/or peri-implant disease state with extremely high accuracy.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {4}
}

Patent:

Save / Share:

Works referenced in this record:

Immunomagnetic Diffractometry for Detection of Diagnostic Serum Markers
journal, December 2007


The area above the ordinal dominance graph and the area below the receiver operating characteristic graph
journal, November 1975


Bacterial Infection Promotes DNA Hypermethylation
journal, February 2007


Analytical epidemiology of periodontitis
journal, October 2005


Random Forests
journal, January 2001


A Microfluidic System for Saliva-Based Detection of Infectious Diseases
journal, March 2007


Lab-on-a-Chip Methods for Point-of-Care Measurements of Salivary Biomarkers of Periodontitis
journal, March 2007


Performance of an oral fluid rapid HIV-1/2 test: experience from four CDC studies
journal, January 2006


Killing the messenger: short RNAs that silence gene expression
journal, June 2003


Clinical risk indicators for periodontal attachment loss
journal, February 1991


Microfluidic immunoassays as rapid saliva-based clinical diagnostics
journal, March 2007


Oral Fluid-Based Biomarkers of Alveolar Bone Loss in Periodontitis
journal, March 2007


Microarray methods for protein biomarker detection
journal, January 2008


Salivary Transcriptome Diagnostics for Oral Cancer Detection
journal, December 2004


Trypsin-Like Activity in Subgingival Plaque: A Diagnostic Marker for Spirochetes and Periodontal Disease?
journal, April 1987


Salivary diagnostics
journal, March 2006


Lab-on-a-Chip Technologies for Oral-Based Cancer Screening and Diagnostics: Capabilities, Issues, and Prospects
journal, March 2007


Improving the efficiency of RNA interference in mammals
journal, May 2004


Prevalence of periodontal pathogens in localized and generalized forms of early-onset periodontitis
journal, August 2000


Relationship between C-telopeptide pyridinoline cross-links (ICTP) and putative periodontal pathogens in periodontitis
journal, November 1998


High Throughput Proteome Screening for Biomarker Detection
journal, January 2005


Rapid Quantitative Chairside Test for Active MMP-8 in Gingival Crevicular Fluid: First Clinical Data
journal, March 2007


Sensitive protein detection via triple-binder proximity ligation assays
journal, December 2006


Quantitation of Bacteroides forsythus in subgingival plaque
journal, January 2000


Serum Antibodies to Porphyromonas gingivalis Chaperone HtpG Predict Health in Periodontitis Susceptible Patients
journal, April 2008


Microbial complexes in subgingival plaque
journal, February 1998


Diagnostic Biomarkers for Oral and Periodontal Diseases
journal, July 2005


Point-of-Care Diagnostics Enter the Mouth
journal, March 2007


Microfluidic diagnostic technologies for global public health
journal, July 2006


Targeted biomarker detection via whole protein ion trap tandem mass spectrometry: thymosin ?4 in a human lung cancer cell line
journal, January 2005


Salivary mRNA targets for cancer diagnostics
journal, May 2008


Treponema socranskii, Treponema denticola, and Porphyromonas gingivalis Are Associated With Severity of Periodontal Tissue Destruction
journal, October 2001