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Title: Chimeric enzymes with improved cellulase activities

Nucleic acid molecules encoding chimeric cellulase polypeptides that exhibit improved cellulase activities are disclosed herein. The chimeric cellulase polypeptides encoded by these nucleic acids and methods to produce the cellulases are also described, along with methods of using chimeric cellulases for the conversion of cellulose to sugars such as glucose.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1177097
Assignee:
Alliance for Sustainable Energy, LLC (Golden, CO) GFO
Patent Number(s):
8,993,276
Application Number:
13/940,936
Contract Number:
AC36-08GO28308
Resource Relation:
Patent File Date: 2013 Jul 12
Research Org:
National Renewable Energy Lab. (NREL), Golden, CO (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 09 BIOMASS FUELS

Other works cited in this record:

Conversion of a β-Ketoacyl Synthase to a Malonyl Decarboxylase by Replacement of the Active-Site Cysteine with Glutamine
journal, September 1999
  • Witkowski, Andrzej; Joshi, Anil K.; Lindqvist, Ylva
  • Biochemistry, Vol. 38, Issue 36, p. 11643-11650
  • DOI: 10.1021/bi990993h

Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identical but Functionally Different
journal, April 2001

Multidomain and Multifunctional Glycosyl Hydrolases from the Extreme Thermophile Caldicellulosiruptor Isolate Tok7B.1
journal, May 2000
  • Gibbs, Moreland D.; Reeves, Rosalind A.; Farrington, G. King
  • Current Microbiology, Vol. 40, Issue 5, p. 333-340
  • DOI: 10.1007/s002849910066

Construction and characterization of chimeric cellulases with enhanced catalytic activity towards insoluble cellulosic substrates
journal, May 2012

Cellulases and biofuels
journal, June 2009

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