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Title: Photoreactive synthetic regulator of protein function and methods of use thereof

The present disclosure provides a photoreactive synthetic regulator of protein function. The present disclosure further provides a light-regulated polypeptide that includes a subject synthetic regulator. Also provided are cells and membranes comprising a subject light-regulated polypeptide. The present disclosure further provides methods of modulating protein function, involving use of light.
Inventors:
; ; ; ; ;
Issue Date:
OSTI Identifier:
1177034
Assignee:
The Regents of the University of California (Oakland, CA) CHO
Patent Number(s):
8,993,736
Application Number:
13/059,052
Contract Number:
AC02-05CH11231
Resource Relation:
Patent File Date: 2010 May 06
Research Org:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

Biologically Active Molecules with a “Light Switch”
journal, July 2006
  • Mayer, Günter; Heckel, Alexander
  • Angewandte Chemie International Edition, Vol. 45, Issue 30, p. 4900-4921
  • DOI: 10.1002/anie.200600387

Blockage of squid axon potassium conductance by internal tetra-N-alkylammonium ions of various sizes
journal, May 1981