Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17

Gray, Joe W.; Pinkel, Daniel; Kallioniemi, Olli-Pekka; Kallioniemi, Anne; Sakamoto, Masaru

Title: Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17

Abstract

Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.

Inventors:: Gray, Joe W.; Pinkel, Daniel; Kallioniemi, Olli-Pekka; Kallioniemi, Anne; Sakamoto, Masaru

Issue Date:: 2008-09-09

Research Org.:: Univ. of California, Oakland, CA (United States); Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1176710

Patent Number(s):: RE40494

Application Number:: 11/398,456

Assignee:: The Regents of the University of California (Oakland, CA)

DOE Contract Number:: W-7405-ENG48

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Gray, Joe W., Pinkel, Daniel, Kallioniemi, Olli-Pekka, Kallioniemi, Anne, and Sakamoto, Masaru. Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17.  United States: N. p., 2008. 
        Web.

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                    Gray, Joe W., Pinkel, Daniel, Kallioniemi, Olli-Pekka, Kallioniemi, Anne, & Sakamoto, Masaru. Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17.  United States.

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                    Gray, Joe W., Pinkel, Daniel, Kallioniemi, Olli-Pekka, Kallioniemi, Anne, and Sakamoto, Masaru. Tue .  
        "Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17".  United States.  https://www.osti.gov/servlets/purl/1176710.

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@article{osti_1176710,

  title        = {Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17},

  author       = {Gray, Joe W. and Pinkel, Daniel and Kallioniemi, Olli-Pekka and Kallioniemi, Anne and Sakamoto, Masaru},

  abstractNote = {Methods and compositions for staining based upon nucleic acid sequence that employ nucleic acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, in the detection of disease related loci, specifically cancer, such as chronic myelogenous leukemia (CML), retinoblastoma, ovarian and uterine cancers, and for biological dosimetry. Methods and reagents are described for cytogenetic research, for the differentiation of cytogenetically similar but genetically different diseases, and for many prognostic and diagnostic applications.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2008},

  month        = {9}

}

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Localization of a unique gene by direct hybridization in situ.
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Gerhard, D. S.; Kawasaki, E. S.; Bancroft, F. C.
Proceedings of the National Academy of Sciences, Vol. 78, Issue 6
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Quantitation of in situ hybridization of ribosomal ribonucleic acids to human diploid cells
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Cot�, Babette D.; Uhlenbeck, Olke C.; Steffensen, Dale M.
Chromosoma, Vol. 80, Issue 3
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Organization and chromosomal specificity of autosomal homologs of human Y chromosome repeated DNA
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Burk, Robert D.; Szabo, Paul; O'Brien, Steve
Chromosoma, Vol. 92, Issue 3
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Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future
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Ray, Arghya; Nordén, Bengt
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Detection of a human chromosomal translocation t(8;9) in a baby with multiple malformations using two-color fluorescence in situ hybridization
journal, February 1994

Sasaki, Kohsuke; Pinkel, Daniel; Tsukahara, Masato
Pathology International, Vol. 44, Issue 2
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A polymorphic locus on the long arm of chromosome 20 defined by two probes from a single cosmid
journal, August 1986

Litt, M.; Sheehy, R.; Bruns, G. A.
Human Genetics, Vol. 73, Issue 4
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Cytogenetic Analysis by In Situ Hybridization with Fluorescently Labeled Nucleic Acid Probes
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Pinkel, D.; Gray, J. W.; Trask, B.
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Landegent, J. E.; De Wal, N. Jansen In; Baan, R. A.
Experimental Cell Research, Vol. 153, Issue 1
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A new era in mammalian gene mapping: somatic cell genetics and recombinant DNA methodologies
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Ruddle, F. H.
Nature, Vol. 294, Issue 5837
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A highly polymorphic locus in human DNA revealed by cosmid-derived probes.
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Litt, M.; White, R. L.
Proceedings of the National Academy of Sciences, Vol. 82, Issue 18
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Biotin and fluorescent labeling of RNA using T4 RNA ligase
journal, January 1983

Richardson, Ross W.; Gumport, Richard I.
Nucleic Acids Research, Vol. 11, Issue 18
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Three-color fluorescence in situ hybridization for the simultaneous detection of multiple nucleic acid sequences
journal, January 1989

Nederlof, P. M.; Robinson, D.; Abuknesha, R.
Cytometry, Vol. 10, Issue 1
https://doi.org/10.1002/cyto.990100105

In Situ Detection of Supernumerary Aberrations of Chromosome-Specific Repetitive DNA Targets in Interphase Nuclei in Human Melanoma Cell Lines and Tissue Sections
journal, April 1992

de Wit, Peter E. J.; Hopman, Anton H. N.; van Muijen, Goos N. P.
Journal of Investigative Dermatology, Vol. 98, Issue 4
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Construction and characterization of genomic libraries from specific human chromosomes.
journal, May 1982

Krumlauf, R.; Jeanpierre, M.; Young, B. D.
Proceedings of the National Academy of Sciences, Vol. 79, Issue 9
https://doi.org/10.1073/pnas.79.9.2971

Cytogenetic and molecular analysis in Philadelphia negative CML
journal, March 1989

van der Plas, Dc; Hermans, Ab; Soekarman, D.
Blood, Vol. 73, Issue 4
https://doi.org/10.1182/blood.V73.4.1038.1038

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Methods and compositions for staining based upon nucleic acid sequence that employ .[.nudeic.]. .Iadd.nucleic .Iaddend.acid probes are provided. Said methods produce staining patterns that can be tailored for specific cytogenetic analyses. Said probes are appropriate for in situ hybridization and stain both interphase and metaphase chromosomal material with reliable signals. The nucleic acid probes are typically of a complexity greater than 50 kb, the complexity depending upon the cytogenetic application. Methods and reagents are provided for the detection of genetic rearrangements. Probes and test kits are provided for use in detecting genetic rearrangements, particularly for use in tumor cytogenetics, inmore »« less
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Title: Chromosome-specific staining to detect genetic rearrangements associated with chromosome 3 and/or chromosome 17

Abstract

Citation Formats

On the heterogeneity of the slow reassociating (?unique?) DNA journal, June 1978

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia. journal, March 1986

Cytogenetic profiling using fluorescencein situ hybridization (FISH) and comparative genomic hybridization (CGH) journal, January 1993

Preparative dual-beam sorting of the human Y chromosome and in situ hybridization of cloned DNA probes journal, November 1984

Detection of the Philadelphia chromosome in interphase nuclei journal, January 1990

Kinetics for Hybridization of Peptide Nucleic Acids (PNA) with DNA and RNA Studied with the BIAcore Technique † journal, April 1997

A direct estimate of the number of human γ-globin genes journal, May 1976

Chromosomal localization of a single copy gene by in situ hybridization - human ? globin genes on the short arm of chromosome 11 journal, May 1981

Four restriction fragment length polymorphisms revealed by probes from a single cosmid map to human chromosome 12q journal, January 1986

Autoradiographic Detection of Molecular Hybrids between rRNA and DNA in Tissue Sections journal, March 1970

Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization journal, October 1990

The application of DNA recombinant technology to the analysis of the human genome and genetic disease journal, October 1981

Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes journal, August 1984

Quantitative in situ hybridization of ribosomal RNA species to polytene chromosomes of Drosophila melanogaster journal, September 1977

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia journal, November 1983

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization. journal, June 1992

The 200-kb segmental duplication on human chromosome 21 originates from a pericentromeric dissemination involving human chromosomes 2, 18 and 13 journal, July 2003

A Limited Number of Globin Genes in Human DNA journal, October 1974

Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84 journal, December 1986

Translocation of c-myc in the hereditary renal cell carcinoma associated with a t(3;8)(p14.2;q24.13) chromosomal translocation. journal, October 1985

Interphase cytogenetics in pathology: principles, methods, and applications of fluorescence in situ hybridization (FISH) journal, October 1997

Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization journal, July 1981

Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization journal, August 1986

Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. journal, May 1986

Organization and heterogeneity of sequences within a repeating unit of human Y chromosome deoxyribonucleic acid journal, July 1979

Mapping muscle protein genes by in situ hybridization using biotin-labeled probes. journal, October 1985

Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization journal, December 1987

A highly polymorphic locus on chromosome 16q revealed by a probe from a chromosome-specific cosmid library journal, December 1986

Detection of chromosome aberrations in interphase tumor nuclei by nonradioactive in situ hybridization journal, October 1989

Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia journal, March 2004

Human chromosome-specific repetitive DNA sequences: novel markers for genetic analysis journal, October 1987

Chemically modified nucleic acids as immunodetectable probes in hybridization experiments. journal, June 1984

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. journal, August 1979

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes journal, November 1988

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries journal, November 1988

Formation and Detection of Rna-Dna Hybrid Molecules in Cytological Preparations journal, June 1969

Hemolytic disease of the newborn caused by a new deletion of the entire beta-globin cluster. journal, August 1983

PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules journal, October 1993

Acceleration of DNA renaturation rates journal, December 1975

Partial trisomy of the long arm of human chromosome 1 as demonstrated by in situ hybridization with 5S ribosomal RNA journal, January 1977

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide journal, December 1991

Construction of fifteen human chromosome-specific DNA libraries from flow-purified chromosomes journal, January 1986

Differential distribution of long and short interspersed element sequences in the mouse genome: chromosome karyotyping by fluorescence in situ hybridization. journal, October 1990

A procedure for the isolation of deoxyribonucleic acid from micro-organisms journal, April 1961

Hybridization histochemistry journal, August 1985

The DNA sequence of human chromosome 21 journal, May 2000

Fluorescence in situ hybridization with Alu and L1 polymerase chain reaction probes for rapid characterization of human chromosomes in hybrid cell lines. journal, September 1990

A new method for fluorescence microscopical localization of specific DNA sequences by in situ hybridization of fluorochrome-labelled RNA journal, August 1980

Genomic mismatch scanning: a new approach to genetic linkage mapping journal, May 1993

Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8 journal, June 1990

General method for cloning amplified DNA by differential screening with genomic probes. journal, May 1982

A noninvasive method for determination of the sex and karyotype of the fetus from the maternal blood journal, August 1988

Detection of aneuploidy and possible deletion in paraffin-embedded rhabdomyosarcoma cells with FISH journal, July 1993

Direct carrier detection by in situ suppression hybridization with cosmid clones of the Duchenne/Becker muscular dystrophy locus journal, October 1990

Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes journal, March 1985

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4. journal, December 1988

Rapid detection of human chromosome 21 aberrations by in situ hybridization. journal, December 1988

In situ hybridization and translocation breakpoint mapping journal, January 1985

Multiple sex chromosomes in Drosophila miranda: A system to study the degeneration of a chromosome journal, September 1982

Chemical synthesis of oligonucleotides containing a free sulphydryl group and subsequent attachment of thiol specific probes journal, January 1985

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors journal, August 1994

One FISH, two FISH, red FISH, blue FISH journal, April 1996

Analysis of a dispersed repetitive DNA sequence in isogenic lines of Drosophila journal, May 1981

Cytogenetics of the parthenogenetic grasshopper Warramaba virgo and its bisexual relatives: VII. Evidence from repeated DNA sequences for a dual origin of W. virgo journal, May 1981

Denaturation, renaturation, and loss of DNA during in situ hybridization procedures journal, May 1986

Removal of repeated sequences from hybridisation probes journal, January 1985

Improved technique for analysis of formalin-fixed, paraffin-embedded tumors by fluorescence in situ hybridization journal, June 1994

Quantitative in situ hybridization reveals extent of sequence homology between related DNA sequences in Drosophila melanogaster journal, July 1981

Characterization of chromosomal anomalies in human breast cancer journal, October 1990

Bi-color detection of two target DNAs by non-radioactive in situ hybridization journal, January 1986

Fluorescence In Situ Hybridization in Cancer and Radiation Biology journal, March 1994

New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile journal, December 2002

Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia journal, August 1985

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA journal, December 1978

Fish technology in chromosome and genome research journal, January 1997

Feasibility of in situ hybridisation with chromosome specific DNA probes on paraffin wax embedded tissue. journal, November 1991

Proto-oncogene amplification and homogeneously staining regions in human breast carcinomas journal, May 1990

On the heterogeneity of the slow reassociating (?unique?) DNA
journal, June 1978

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.
journal, March 1986

Cytogenetic profiling using fluorescencein situ hybridization (FISH) and comparative genomic hybridization (CGH)
journal, January 1993

Preparative dual-beam sorting of the human Y chromosome and in situ hybridization of cloned DNA probes
journal, November 1984

Detection of the Philadelphia chromosome in interphase nuclei
journal, January 1990

Kinetics for Hybridization of Peptide Nucleic Acids (PNA) with DNA and RNA Studied with the BIAcore Technique ^†
journal, April 1997

A direct estimate of the number of human γ-globin genes
journal, May 1976

Chromosomal localization of a single copy gene by in situ hybridization - human ? globin genes on the short arm of chromosome 11
journal, May 1981

Four restriction fragment length polymorphisms revealed by probes from a single cosmid map to human chromosome 12q
journal, January 1986

Autoradiographic Detection of Molecular Hybrids between rRNA and DNA in Tissue Sections
journal, March 1970

Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization
journal, October 1990

The application of DNA recombinant technology to the analysis of the human genome and genetic disease
journal, October 1981

Sex chromosome positions in human interphase nuclei as studied by in situ hybridization with chromosome specific DNA probes
journal, August 1984

Quantitative in situ hybridization of ribosomal RNA species to polytene chromosomes of Drosophila melanogaster
journal, September 1977

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia
journal, November 1983

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.
journal, June 1992

The 200-kb segmental duplication on human chromosome 21 originates from a pericentromeric dissemination involving human chromosomes 2, 18 and 13
journal, July 2003

A Limited Number of Globin Genes in Human DNA
journal, October 1974

Detection of chromosome aberrations in the human interphase nucleus by visualization of specific target DNAs with radioactive and non-radioactive in situ hybridization techniques: diagnosis of trisomy 18 with probe L1.84
journal, December 1986

Translocation of c-myc in the hereditary renal cell carcinoma associated with a t(3;8)(p14.2;q24.13) chromosomal translocation.
journal, October 1985

Interphase cytogenetics in pathology: principles, methods, and applications of fluorescence in situ hybridization (FISH)
journal, October 1997

Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridization
journal, July 1981

Fine mapping of the Huntington disease linked D4S10 locus by non-radioactive in situ hybridization
journal, August 1986

Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization.
journal, May 1986

Organization and heterogeneity of sequences within a repeating unit of human Y chromosome deoxyribonucleic acid
journal, July 1979

Mapping muscle protein genes by in situ hybridization using biotin-labeled probes.
journal, October 1985

Use of whole cosmid cloned genomic sequences for chromosomal localization by non-radioactive in situ hybridization
journal, December 1987

A highly polymorphic locus on chromosome 16q revealed by a probe from a chromosome-specific cosmid library
journal, December 1986

Detection of chromosome aberrations in interphase tumor nuclei by nonradioactive in situ hybridization
journal, October 1989

Split-signal FISH for detection of chromosome aberrations in acute lymphoblastic leukemia
journal, March 2004

Human chromosome-specific repetitive DNA sequences: novel markers for genetic analysis
journal, October 1987

Chemically modified nucleic acids as immunodetectable probes in hybridization experiments.
journal, June 1984

Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.
journal, August 1979

Detection of chromosome aberrations in metaphase and interphase tumor cells by in situ hybridization using chromosome-specific library probes
journal, November 1988

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries
journal, November 1988

Formation and Detection of Rna-Dna Hybrid Molecules in Cytological Preparations
journal, June 1969

Hemolytic disease of the newborn caused by a new deletion of the entire beta-globin cluster.
journal, August 1983

PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
journal, October 1993

Acceleration of DNA renaturation rates
journal, December 1975

Partial trisomy of the long arm of human chromosome 1 as demonstrated by in situ hybridization with 5S ribosomal RNA
journal, January 1977

Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
journal, December 1991

Construction of fifteen human chromosome-specific DNA libraries from flow-purified chromosomes
journal, January 1986

Differential distribution of long and short interspersed element sequences in the mouse genome: chromosome karyotyping by fluorescence in situ hybridization.
journal, October 1990

A procedure for the isolation of deoxyribonucleic acid from micro-organisms
journal, April 1961

Hybridization histochemistry
journal, August 1985

The DNA sequence of human chromosome 21
journal, May 2000

Fluorescence in situ hybridization with Alu and L1 polymerase chain reaction probes for rapid characterization of human chromosomes in hybrid cell lines.
journal, September 1990

A new method for fluorescence microscopical localization of specific DNA sequences by in situ hybridization of fluorochrome-labelled RNA
journal, August 1980

Genomic mismatch scanning: a new approach to genetic linkage mapping
journal, May 1993

Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8
journal, June 1990

General method for cloning amplified DNA by differential screening with genomic probes.
journal, May 1982

A noninvasive method for determination of the sex and karyotype of the fetus from the maternal blood
journal, August 1988

Detection of aneuploidy and possible deletion in paraffin-embedded rhabdomyosarcoma cells with FISH
journal, July 1993

Direct carrier detection by in situ suppression hybridization with cosmid clones of the Duchenne/Becker muscular dystrophy locus
journal, October 1990

Two homoeo box loci mapped in evolutionarily related mouse and human chromosomes
journal, March 1985

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.
journal, December 1988

Rapid detection of human chromosome 21 aberrations by in situ hybridization.
journal, December 1988

In situ hybridization and translocation breakpoint mapping
journal, January 1985

Multiple sex chromosomes in Drosophila miranda: A system to study the degeneration of a chromosome
journal, September 1982

Chemical synthesis of oligonucleotides containing a free sulphydryl group and subsequent attachment of thiol specific probes
journal, January 1985

Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors
journal, August 1994

One FISH, two FISH, red FISH, blue FISH
journal, April 1996

Analysis of a dispersed repetitive DNA sequence in isogenic lines of Drosophila
journal, May 1981

Cytogenetics of the parthenogenetic grasshopper Warramaba virgo and its bisexual relatives: VII. Evidence from repeated DNA sequences for a dual origin of W. virgo
journal, May 1981

Denaturation, renaturation, and loss of DNA during in situ hybridization procedures
journal, May 1986

Removal of repeated sequences from hybridisation probes
journal, January 1985

Improved technique for analysis of formalin-fixed, paraffin-embedded tumors by fluorescence in situ hybridization
journal, June 1994

Quantitative in situ hybridization reveals extent of sequence homology between related DNA sequences in Drosophila melanogaster
journal, July 1981

Characterization of chromosomal anomalies in human breast cancer
journal, October 1990

Bi-color detection of two target DNAs by non-radioactive in situ hybridization
journal, January 1986

Fluorescence In Situ Hybridization in Cancer and Radiation Biology
journal, March 1994

New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric regions of human chromosomes 13 and 21 have a cancer/testis expression profile
journal, December 2002

Translocation of the p53 gene in t(15;17) in acute promyelocytic leukaemia
journal, August 1985

The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNA
journal, December 1978

Fish technology in chromosome and genome research
journal, January 1997

Feasibility of in situ hybridisation with chromosome specific DNA probes on paraffin wax embedded tissue.
journal, November 1991

Proto-oncogene amplification and homogeneously staining regions in human breast carcinomas
journal, May 1990

Use of DNA and Peptide Nucleic Acid Molecular Beacons for Detection and Quantification of rRNA in Solution and in Whole Cells
journal, September 2003

Localization of sequences specifying messenger RNA to light-staining G-bands of human chromosomes
journal, January 1977

The activity of two heat shock loci of Drosophila hydei in tissue culture cells and salivary gland cells as analyzed by in situ hybridization of complementary DNA
journal, January 1979