No-carrier-added (18F)-N-methylspiroperidol
Abstract
There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [18F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [18F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1176656
- Patent Number(s):
- H001209
- Application Number:
- 06/784149
- Assignee:
- The United States of America as represented by the United States Department of Energy (Washington, DC)
- DOE Contract Number:
- AC02-76CH00016
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 1985 Oct 04
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; statutory invention registration
Citation Formats
Shiue, Chyng-Yann, Fowler, Joanna S., and Wolf, Alfred P. No-carrier-added (18F)-N-methylspiroperidol. United States: N. p., 1993.
Web.
Shiue, Chyng-Yann, Fowler, Joanna S., & Wolf, Alfred P. No-carrier-added (18F)-N-methylspiroperidol. United States.
Shiue, Chyng-Yann, Fowler, Joanna S., and Wolf, Alfred P. Tue .
"No-carrier-added (18F)-N-methylspiroperidol". United States. https://www.osti.gov/servlets/purl/1176656.
@article{osti_1176656,
title = {No-carrier-added (18F)-N-methylspiroperidol},
author = {Shiue, Chyng-Yann and Fowler, Joanna S. and Wolf, Alfred P.},
abstractNote = {There is disclosed a radioligand labeled with a positron emitting radionuclide suitable for dynamic study in living humans with positron emission transaxial tomography. [18F]-N-methylspiroperidol, exhibiting extremely high affinity for the dopamine receptors, provides enhanced uptake and retention in the brain concomitant with reduced radiation burden. These characteristics all combine to provide [18F]-N-methylspiroperidol as a radioligand superior to known radioligands for mapping dopamine receptors in normal and disease states in the living brain. Additionally, a new synthetic procedure for this material is disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1993},
month = {7}
}
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Works referenced in this record:
Imaging dopamine receptors in the human brain by positron tomography
journal, September 1983
- Wagner, H.; Burns, H.; Dannals, R.
- Science, Vol. 221, Issue 4617
Preliminary studies with [18F]haloperidol: a radioligand for in vivo studies of the dopamine receptors
journal, June 1980
- Tewson, T. J.; Raichle, M. E.; Welch, M. J.
- Brain Research, Vol. 192, Issue 1