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Title: Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2

Abstract

A stable boronated (10B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [10B]Na4B24H22S2, at a dose of about 200 $$\mu$$g 10B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 $$\mu$$g 10B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of 10B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of 10B in the tumor.

Inventors:
; ;
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176581
Patent Number(s):
H000505
Application Number:
06/838494
Assignee:
The United States of America as represented by the United States Department of Energy (Washington, DC)
DOE Contract Number:  
AC02-76CH00016
Resource Type:
Patent
Resource Relation:
Patent File Date: 1986 Mar 11
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; statutory invention registration

Citation Formats

Slatkin, Daniel N., Micca, Peggy L., and Fairchild, Ralph G. Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2. United States: N. p., 1988. Web.
Slatkin, Daniel N., Micca, Peggy L., & Fairchild, Ralph G. Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2. United States.
Slatkin, Daniel N., Micca, Peggy L., and Fairchild, Ralph G. Tue . "Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2". United States. https://www.osti.gov/servlets/purl/1176581.
@article{osti_1176581,
title = {Boron uptake in tumors, cerebrum and blood from [10B]NA4B24H22S2},
author = {Slatkin, Daniel N. and Micca, Peggy L. and Fairchild, Ralph G.},
abstractNote = {A stable boronated (10B-labeled) compound, sodium mercaptoundecahydrododecaborate is infused in the form of the disulfide dimer, [10B]Na4B24H22S2, at a dose of about 200 $\mu$g 10B per gm body weight. The infusion is performed into the blood or peritoneal cavity of the patient slowly over a period of many days, perhaps one week or more, at the rate of roughly 1 $\mu$g 10B per gm body weight per hour. Use of this particular boronated dimer in the manner or similarly to the manner so described permits radiotherapeutically effective amounts of boron to accumulate in tumors to be treated by boron neutron capture radiation therapy and also permits sufficient retention of boron in tumor after the cessation of the slow infusion, so as to allow the blood concentration of 10B to drop or to be reduced artificially to a radiotherapeutically effective level, less than one-half of the concentration of 10B in the tumor.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {1988},
month = {8}
}

Works referenced in this record:

Boron Neutron Capture Therapy of Cerebral Gliomas
journal, January 1975


A revised boron-neutron capture therapy for malignant brain tumours
journal, January 1973