Title: Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides

Abstract

The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.

Inventors:

Raymond, Kenneth N.; Xu, Jide; Moore, Evan G.; Werner, Eric J.

Issue Date:

2013-10-15

Research Org.:

Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1176518

Patent Number(s):

8557601

Application Number:

12/373,275

Assignee:

The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):

C - CHEMISTRY C09 - DYES C09K - MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

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C - CHEMISTRY C09 - DYES C09K - MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE

C09K2211/185 - of the platinum group, i.e. Os, Ir, Pt, Ru, Rh or Pd

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS

C07D217/26 - Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D213/89 - with hetero atoms directly attached to the ring nitrogen atom

H - ELECTRICITY H05 - ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR H05B - ELECTRIC HEATING

H05B33/14 - characterised by the chemical or physical composition or the arrangement of the electroluminescent material {, or by the simultaneous addition of the electroluminescent material in or onto the light source}

C - CHEMISTRY C09 - DYES C09K - MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE

C09K2211/1088 - containing oxygen as the only heteroatom
C09K2211/1022 - bridged by heteroatoms, e.g. N, P, Si or B
C09K11/06 - containing organic luminescent materials
C09K2211/1044 - containing two nitrogen atoms as heteroatoms
C09K2211/1029 - containing one nitrogen atom as the heteroatom

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DOE Contract Number:  

AC03-76SF00098

Resource Type:

Patent

Resource Relation:

Patent File Date: 2007 Jul 10

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY