Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

Hibbs, Michael; Altman, Susan J.; Jones, Howland D.T.; Savage, Paul B.

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Title: Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

Abstract

This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.

Inventors:: Hibbs, Michael; Altman, Susan J.; Jones, Howland D.T.; Savage, Paul B.

Issue Date:: Tue Oct 15 00:00:00 EDT 2013

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1176511

Patent Number(s):: 8557031

Application Number:: 12/986,215

Assignee:: Sandia Corporation

Patent Classifications (CPCs):: C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS

C - CHEMISTRY C09 - DYES C09D - COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS

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C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C08F2/48 - by ultra-violet or visible light

C - CHEMISTRY C09 - DYES C09D - COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS
C09D5/1637 - {Macromolecular compounds}
C09D5/1675 - {Polyorganosiloxane-containing compositions}

Show less

DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2011 Jan 07

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Hibbs, Michael, Altman, Susan J., Jones, Howland D.T., and Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages.  United States: N. p., 2013. 
        Web.

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                    Hibbs, Michael, Altman, Susan J., Jones, Howland D.T., & Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages.  United States.

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                    Hibbs, Michael, Altman, Susan J., Jones, Howland D.T., and Savage, Paul B. Tue .  
        "Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages".  United States.  https://www.osti.gov/servlets/purl/1176511.

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@article{osti_1176511,

  title        = {Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages},

  author       = {Hibbs, Michael and Altman, Susan J. and Jones, Howland D.T. and Savage, Paul B.},

  abstractNote = {This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Oct 15 00:00:00 EDT 2013},

  month        = {Tue Oct 15 00:00:00 EDT 2013}

}

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Works referenced in this record:

Synthesis and Characterization of Peptide−Cationic Steroid Antibiotic Conjugates
journal, September 2004

Ding, Bangwei; Taotofa, Uale; Orsak, Thomas
Organic Letters, Vol. 6, Issue 20
https://doi.org/10.1021/ol048845t

Composite membrane with polyalkylene oxide modified polyamide surface
patent, August 2001

Mickols, William E.
US Patent Document 6,280,853
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6280853

Polyacrylamide brush coatings preventing microbial adhesion to silicone rubber
journal, July 2008

Fundeanu, Irina; van der Mei, Henny C.; Schouten, Arend J.
Colloids and Surfaces B: Biointerfaces, Vol. 64, Issue 2
https://doi.org/10.1016/j.colsurfb.2008.02.005

Characterization of isolated polyamide thin films of RO and NF membranes using novel TEM techniques
journal, August 2010

Pacheco, Federico A.; Pinnau, Ingo; Reinhard, Martin
Journal of Membrane Science, Vol. 358, Issue 1-2
https://doi.org/10.1016/j.memsci.2010.04.032

Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides
journal, July 2008

Lai, Xin-Zhong; Feng, Yanshu; Pollard, Jacob
Accounts of Chemical Research, Vol. 41, Issue 10
https://doi.org/10.1021/ar700270t

Composite membrane and method for making the same
patent, April 2005

Mickols, William E.
US Patent Document 6,878,278
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6878278

Antibacterial Activities of Thin Films Containing Ceragenins
book, May 2008

Savage, Paul B.; Nielsen, Jason; Lai, Xin-Zhong
ACS Symposium Series
https://doi.org/10.1021/bk-2008-0984.ch005

Functionalized substrates
patent, June 2009

Waller, Jr., Clinton P.; Weiss, Douglas E.
US Patent Document 7,553,417
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7553417

Cationic Steroid Antibiotics
journal, July 2002

Savage, P.
Current Medicinal Chemistry -Anti-Infective Agents, Vol. 1, Issue 3
https://doi.org/10.2174/1568012023354776

Synthesis and Characterization of Surface-Grafted Polyacrylamide Brushes and Their Inhibition of Microbial Adhesion
journal, March 2007

Cringus-Fundeanu, Irina; Luijten, Jeroen; van der Mei, Henny C.
Langmuir, Vol. 23, Issue 9
https://doi.org/10.1021/la063531v

Steroid derived antibiotics
patent, July 2004

Savage, Paul B.; Li, Chunhong
US Patent Document 6,767,904
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6767904

Fouling of Reverse Osmosis and Ultrafiltration Membranes: A Critical Review
journal, January 2005

Goosen, M. F. A.; Sablani, S. S.; Al‐Hinai, H.
Separation Science and Technology, Vol. 39, Issue 10
https://doi.org/10.1081/SS-120039343

Process for improving membranes
patent, March 2010

Belfer, Sophia; Fainstein, Rosalia; Kesselman, Luba
US Patent Document 7,677,398
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7677398

Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide
journal, March 2004

Zhu, Yabin; Gao, Changyou; Guan, Jianjun
Journal of Materials Science: Materials in Medicine, Vol. 15, Issue 3
https://doi.org/10.1023/B:JMSM.0000015489.27261.f0

Surface modification of commercial composite polyamide reverse osmosis membranes
journal, February 1998

Belfer, S.; Purinson, Y.; Fainshtein, R.
Journal of Membrane Science, Vol. 139, Issue 2
https://doi.org/10.1016/S0376-7388(97)00248-2

Membrane which comprises a blend of a polysulphone or a polyether sulphone and polyethylene oxide/polypropylene oxide substituted ethylene diamine
patent, December 2002

Heijnen, Martin
US Patent Document 6,495,043
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6495043

Steroid derived antibiotics
patent, February 2002

Savage, Paul B.; Li, Chunhong
US Patent Document 6,350,738
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6350738

Photoinduced graft polymerization of acrylamide on polypropylene microporous membranes for the improvement of antifouling characteristics in a submerged membrane-bioreactor
journal, February 2007

Yu, H.; Xu, Z.; Lei, H.
Separation and Purification Technology, Vol. 53, Issue 1
https://doi.org/10.1016/j.seppur.2006.07.002

Peptide Antimicrobial Agents
journal, July 2006

Jenssen, Håvard; Hamill, Pamela; Hancock, Robert E. W.
Clinical Microbiology Reviews, Vol. 19, Issue 3
https://doi.org/10.1128/CMR.00056-05

Selective membrane having a high fouling resistance
patent, July 2005

Koo, Ja-Young; Hong, Sung-pyo; Kang, Jin Woo
US Patent Document 6,913,694
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6913694

Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid Antibiotics
journal, December 2001

Ding, Bangwei; Guan, Qunying; Walsh, Joshua P.
Journal of Medicinal Chemistry, Vol. 45, Issue 3
https://doi.org/10.1021/jm0105070

Cationic steroid antimicrobial compositions and methods of use
patent, July 2010

Savage, Paul B.; Leung, Donald Y. M.
US Patent Document 7,754,705
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7754705

Origins of Cell Selectivity of Cationic Steroid Antibiotics
journal, October 2004

Ding, Bangwei; Yin, Ning; Liu, Yang
Journal of the American Chemical Society, Vol. 126, Issue 42
https://doi.org/10.1021/ja046909p

Selective membrane having a high fouling resistance
patent, May 2009

Koo, Ja-Young; Hong, Sung-pyo; Lee, Jong-Hwa
US Patent Document 7,537,697
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7537697

Polyamide membrane with coating of polyalkylene oxide and polyacrylamide compounds
patent, October 2010

Mickols, William E.; Zhang, Chunming
US Patent Document 7,815,987
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/7815987

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Similar Records

Title: Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

Abstract

Citation Formats

Synthesis and Characterization of Peptide−Cationic Steroid Antibiotic Conjugates journal, September 2004

Composite membrane with polyalkylene oxide modified polyamide surface patent, August 2001

Polyacrylamide brush coatings preventing microbial adhesion to silicone rubber journal, July 2008

Characterization of isolated polyamide thin films of RO and NF membranes using novel TEM techniques journal, August 2010

Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides journal, July 2008

Composite membrane and method for making the same patent, April 2005

Antibacterial Activities of Thin Films Containing Ceragenins book, May 2008

Functionalized substrates patent, June 2009

Cationic Steroid Antibiotics journal, July 2002

Synthesis and Characterization of Surface-Grafted Polyacrylamide Brushes and Their Inhibition of Microbial Adhesion journal, March 2007

Steroid derived antibiotics patent, July 2004

Fouling of Reverse Osmosis and Ultrafiltration Membranes: A Critical Review journal, January 2005

Process for improving membranes patent, March 2010

Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide journal, March 2004

Surface modification of commercial composite polyamide reverse osmosis membranes journal, February 1998

Membrane which comprises a blend of a polysulphone or a polyether sulphone and polyethylene oxide/polypropylene oxide substituted ethylene diamine patent, December 2002

Steroid derived antibiotics patent, February 2002

Photoinduced graft polymerization of acrylamide on polypropylene microporous membranes for the improvement of antifouling characteristics in a submerged membrane-bioreactor journal, February 2007

Peptide Antimicrobial Agents journal, July 2006

Selective membrane having a high fouling resistance patent, July 2005

Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid Antibiotics journal, December 2001

Cationic steroid antimicrobial compositions and methods of use patent, July 2010

Origins of Cell Selectivity of Cationic Steroid Antibiotics journal, October 2004

Selective membrane having a high fouling resistance patent, May 2009

Polyamide membrane with coating of polyalkylene oxide and polyacrylamide compounds patent, October 2010

Synthesis and Characterization of Peptide−Cationic Steroid Antibiotic Conjugates
journal, September 2004

Composite membrane with polyalkylene oxide modified polyamide surface
patent, August 2001

Polyacrylamide brush coatings preventing microbial adhesion to silicone rubber
journal, July 2008

Characterization of isolated polyamide thin films of RO and NF membranes using novel TEM techniques
journal, August 2010

Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides
journal, July 2008

Composite membrane and method for making the same
patent, April 2005

Antibacterial Activities of Thin Films Containing Ceragenins
book, May 2008

Functionalized substrates
patent, June 2009

Cationic Steroid Antibiotics
journal, July 2002

Synthesis and Characterization of Surface-Grafted Polyacrylamide Brushes and Their Inhibition of Microbial Adhesion
journal, March 2007

Steroid derived antibiotics
patent, July 2004

Fouling of Reverse Osmosis and Ultrafiltration Membranes: A Critical Review
journal, January 2005

Process for improving membranes
patent, March 2010

Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide
journal, March 2004

Surface modification of commercial composite polyamide reverse osmosis membranes
journal, February 1998

Membrane which comprises a blend of a polysulphone or a polyether sulphone and polyethylene oxide/polypropylene oxide substituted ethylene diamine
patent, December 2002

Steroid derived antibiotics
patent, February 2002

Photoinduced graft polymerization of acrylamide on polypropylene microporous membranes for the improvement of antifouling characteristics in a submerged membrane-bioreactor
journal, February 2007

Peptide Antimicrobial Agents
journal, July 2006

Selective membrane having a high fouling resistance
patent, July 2005

Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid Antibiotics
journal, December 2001

Cationic steroid antimicrobial compositions and methods of use
patent, July 2010

Origins of Cell Selectivity of Cationic Steroid Antibiotics
journal, October 2004

Selective membrane having a high fouling resistance
patent, May 2009

Polyamide membrane with coating of polyalkylene oxide and polyacrylamide compounds
patent, October 2010