Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

Hibbs, Michael; Altman, Susan J.; Jones, Howland D.T.; Savage, Paul B.

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Title: Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

Abstract

This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.

Inventors:: Hibbs, Michael; Altman, Susan J.; Jones, Howland D.T.; Savage, Paul B.

Issue Date:: 2013-10-15

Research Org.:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1176511

Patent Number(s):: 8557031

Application Number:: 12/986,215

Assignee:: Sandia Corporation

Patent Classifications (CPCs):: C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS

C - CHEMISTRY C09 - DYES C09D - COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS

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C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08F - MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
C08F2/48 - by ultra-violet or visible light

C - CHEMISTRY C09 - DYES C09D - COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS
C09D5/1637 - {Macromolecular compounds}
C09D5/1675 - {Polyorganosiloxane-containing compositions}

Show less

DOE Contract Number:: AC04-94AL85000

Resource Type:: Patent

Resource Relation:: Patent File Date: 2011 Jan 07

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Hibbs, Michael, Altman, Susan J., Jones, Howland D.T., and Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages.  United States: N. p., 2013. 
        Web.

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                    Hibbs, Michael, Altman, Susan J., Jones, Howland D.T., & Savage, Paul B. Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages.  United States.

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                    Hibbs, Michael, Altman, Susan J., Jones, Howland D.T., and Savage, Paul B. Tue .  
        "Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages".  United States.  https://www.osti.gov/servlets/purl/1176511.

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@article{osti_1176511,

  title        = {Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages},

  author       = {Hibbs, Michael and Altman, Susan J. and Jones, Howland D.T. and Savage, Paul B.},

  abstractNote = {This invention relates to methods for chemically grafting and attaching ceragenin molecules to polymer substrates; methods for synthesizing ceragenin-containing copolymers; methods for making ceragenin-modified water treatment membranes and spacers; and methods of treating contaminated water using ceragenin-modified treatment membranes and spacers. Ceragenins are synthetically produced antimicrobial peptide mimics that display broad-spectrum bactericidal activity. Alkene-functionalized ceragenins (e.g., acrylamide-functionalized ceragenins) can be attached to polyamide reverse osmosis membranes using amine-linking, amide-linking, UV-grafting, or silane-coating methods. In addition, silane-functionalized ceragenins can be directly attached to polymer surfaces that have free hydroxyls.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2013},

  month        = {10}

}

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Similar Records

Title: Methods for attaching polymerizable ceragenins to water treatment membranes using amine and amide linkages

Abstract

Citation Formats

Synthesis and Characterization of Peptide−Cationic Steroid Antibiotic Conjugates journal, September 2004

Composite membrane with polyalkylene oxide modified polyamide surface patent, August 2001

Polyacrylamide brush coatings preventing microbial adhesion to silicone rubber journal, July 2008

Characterization of isolated polyamide thin films of RO and NF membranes using novel TEM techniques journal, August 2010

Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides journal, July 2008

Composite membrane and method for making the same patent, April 2005

Antibacterial Activities of Thin Films Containing Ceragenins book, May 2008

Functionalized substrates patent, June 2009

Cationic Steroid Antibiotics journal, July 2002

Synthesis and Characterization of Surface-Grafted Polyacrylamide Brushes and Their Inhibition of Microbial Adhesion journal, March 2007

Steroid derived antibiotics patent, July 2004

Fouling of Reverse Osmosis and Ultrafiltration Membranes: A Critical Review journal, January 2005

Process for improving membranes patent, March 2010

Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide journal, March 2004

Surface modification of commercial composite polyamide reverse osmosis membranes journal, February 1998

Membrane which comprises a blend of a polysulphone or a polyether sulphone and polyethylene oxide/polypropylene oxide substituted ethylene diamine patent, December 2002

Steroid derived antibiotics patent, February 2002

Photoinduced graft polymerization of acrylamide on polypropylene microporous membranes for the improvement of antifouling characteristics in a submerged membrane-bioreactor journal, February 2007

Peptide Antimicrobial Agents journal, July 2006

Selective membrane having a high fouling resistance patent, July 2005

Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid Antibiotics journal, December 2001

Cationic steroid antimicrobial compositions and methods of use patent, July 2010

Origins of Cell Selectivity of Cationic Steroid Antibiotics journal, October 2004

Selective membrane having a high fouling resistance patent, May 2009

Polyamide membrane with coating of polyalkylene oxide and polyacrylamide compounds patent, October 2010

Synthesis and Characterization of Peptide−Cationic Steroid Antibiotic Conjugates
journal, September 2004

Composite membrane with polyalkylene oxide modified polyamide surface
patent, August 2001

Polyacrylamide brush coatings preventing microbial adhesion to silicone rubber
journal, July 2008

Characterization of isolated polyamide thin films of RO and NF membranes using novel TEM techniques
journal, August 2010

Ceragenins: Cholic Acid-Based Mimics of Antimicrobial Peptides
journal, July 2008

Composite membrane and method for making the same
patent, April 2005

Antibacterial Activities of Thin Films Containing Ceragenins
book, May 2008

Functionalized substrates
patent, June 2009

Cationic Steroid Antibiotics
journal, July 2002

Synthesis and Characterization of Surface-Grafted Polyacrylamide Brushes and Their Inhibition of Microbial Adhesion
journal, March 2007

Steroid derived antibiotics
patent, July 2004

Fouling of Reverse Osmosis and Ultrafiltration Membranes: A Critical Review
journal, January 2005

Process for improving membranes
patent, March 2010

Promoting the cytocompatibility of polyurethane scaffolds via surface photo-grafting polymerization of acrylamide
journal, March 2004

Surface modification of commercial composite polyamide reverse osmosis membranes
journal, February 1998

Membrane which comprises a blend of a polysulphone or a polyether sulphone and polyethylene oxide/polypropylene oxide substituted ethylene diamine
patent, December 2002

Steroid derived antibiotics
patent, February 2002

Photoinduced graft polymerization of acrylamide on polypropylene microporous membranes for the improvement of antifouling characteristics in a submerged membrane-bioreactor
journal, February 2007

Peptide Antimicrobial Agents
journal, July 2006

Selective membrane having a high fouling resistance
patent, July 2005

Correlation of the Antibacterial Activities of Cationic Peptide Antibiotics and Cationic Steroid Antibiotics
journal, December 2001

Cationic steroid antimicrobial compositions and methods of use
patent, July 2010

Origins of Cell Selectivity of Cationic Steroid Antibiotics
journal, October 2004

Selective membrane having a high fouling resistance
patent, May 2009

Polyamide membrane with coating of polyalkylene oxide and polyacrylamide compounds
patent, October 2010