DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making

Abstract

The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.

Inventors:
; ; ;
Issue Date:
Research Org.:
US Department of Energy (USDOE), Washington DC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176474
Patent Number(s):
8242284
Application Number:
12/862,168
Assignee:
The United States of America as represented by the United States Department of Energy (Washington, DC)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Aug 24
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Gakh, Andrei A., Vovk, Mykhaylo V., Mel'nychenko, Nina V., and Sukach, Volodymyr A. Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making. United States: N. p., 2012. Web.
Gakh, Andrei A., Vovk, Mykhaylo V., Mel'nychenko, Nina V., & Sukach, Volodymyr A. Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making. United States.
Gakh, Andrei A., Vovk, Mykhaylo V., Mel'nychenko, Nina V., and Sukach, Volodymyr A. Tue . "Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making". United States. https://www.osti.gov/servlets/purl/1176474.
@article{osti_1176474,
title = {Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making},
author = {Gakh, Andrei A. and Vovk, Mykhaylo V. and Mel'nychenko, Nina V. and Sukach, Volodymyr A.},
abstractNote = {The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2012},
month = {8}
}

Works referenced in this record:

Synthesis of benzamide derivatives as TRPV1 antagonists
journal, February 2008