Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making
Abstract
The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.
- Inventors:
- Issue Date:
- Research Org.:
- US Department of Energy (USDOE), Washington, DC (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1176474
- Patent Number(s):
- 8242284
- Application Number:
- 12/862,168
- Assignee:
- The United States of America as represented by the United States Department of Energy (Washington, DC)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07D - HETEROCYCLIC COMPOUNDS
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Aug 24
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Gakh, Andrei A., Vovk, Mykhaylo V., Mel'nychenko, Nina V., and Sukach, Volodymyr A. Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making. United States: N. p., 2012.
Web.
Gakh, Andrei A., Vovk, Mykhaylo V., Mel'nychenko, Nina V., & Sukach, Volodymyr A. Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making. United States.
Gakh, Andrei A., Vovk, Mykhaylo V., Mel'nychenko, Nina V., and Sukach, Volodymyr A. Tue .
"Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making". United States. https://www.osti.gov/servlets/purl/1176474.
@article{osti_1176474,
title = {Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making},
author = {Gakh, Andrei A. and Vovk, Mykhaylo V. and Mel'nychenko, Nina V. and Sukach, Volodymyr A.},
abstractNote = {The present disclosure relates to novel compounds having the structural Formulas (1a,1b), stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or pharmaceutically acceptable salt and/or solvate thereof as chemotherapy agents for treating of cancer, particularly androgen-independent prostate cancer. The disclosure also relates to methods for preparing said compounds, and to pharmaceutical compositions comprising said compounds.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Aug 14 00:00:00 EDT 2012},
month = {Tue Aug 14 00:00:00 EDT 2012}
}
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Works referenced in this record:
Synthesis of benzamide derivatives as TRPV1 antagonists
journal, February 2008
- Shishido, Yuji; Jinno, Madoka; Ikeda, Takafumi
- Bioorganic & Medicinal Chemistry Letters, Vol. 18, Issue 3