Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof
Abstract
The present invention provides novel non-immunogenic, hydrophilic/cationic block copolymers comprising a neutral-hydrophilic polymer and a cationic polymer, wherein both polymers have well-defined chain-end functionality. A representative example of such a block copolymer comprises poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and poly(N-[3-(dimethylamino)propyl]methacrylamide) (PDMAPMA). Also provided is a synthesis method thereof in aqueous media via reversible addition fragmentation chain transfer (RAFT) polymerization. Further provided are uses of these block copolymers as drug delivery vehicles and protection agents.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of Southern Mississippi, Hattiesburg, MS (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1176304
- Patent Number(s):
- 7718432
- Application Number:
- 11/725,964
- Assignee:
- The University of Southern Mississippi (Hattiesburg, MS)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- FC26-01BC15317
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2007 Mar 20
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; 60 APPLIED LIFE SCIENCES
Citation Formats
Scales, Charles W., Huang, Faqing, and McCormick, Charles L. Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof. United States: N. p., 2010.
Web.
Scales, Charles W., Huang, Faqing, & McCormick, Charles L. Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof. United States.
Scales, Charles W., Huang, Faqing, and McCormick, Charles L. Tue .
"Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof". United States. https://www.osti.gov/servlets/purl/1176304.
@article{osti_1176304,
title = {Non-immunogenic, hydrophilic/cationic block copolymers and uses thereof},
author = {Scales, Charles W. and Huang, Faqing and McCormick, Charles L.},
abstractNote = {The present invention provides novel non-immunogenic, hydrophilic/cationic block copolymers comprising a neutral-hydrophilic polymer and a cationic polymer, wherein both polymers have well-defined chain-end functionality. A representative example of such a block copolymer comprises poly(N-(2-hydroxypropyl)methacrylamide) (PHPMA) and poly(N-[3-(dimethylamino)propyl]methacrylamide) (PDMAPMA). Also provided is a synthesis method thereof in aqueous media via reversible addition fragmentation chain transfer (RAFT) polymerization. Further provided are uses of these block copolymers as drug delivery vehicles and protection agents.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2010},
month = {5}
}
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