Nucleic acid sequences encoding D1 and D1/D2 domains of human coxsackievirus and adenovirus receptor (CAR)

Freimuth, Paul I.

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Title: Nucleic acid sequences encoding D1 and D1/D2 domains of human coxsackievirus and adenovirus receptor (CAR)

Abstract

The invention provides recombinant human CAR (coxsackievirus and adenovirus receptor) polypeptides which bind adenovirus. Specifically, polypeptides corresponding to adenovirus binding domain D1 and the entire extracellular domain of human CAR protein comprising D1 and D2 are provided. In another aspect, the invention provides nucleic acid sequences encoding these domains and expression vectors for producing the domains and bacterial cells containing such vectors. The invention also includes an isolated fusion protein comprised of the D1 polypeptide fused to a polypeptide which facilitates folding of D1 when expressed in bacteria. The functional D1 domain finds application in a therapeutic method for treating a patient infected with a CAR D1-binding virus, and also in a method for identifying an antiviral compound which interferes with viral attachment. The invention also provides a method for specifically targeting a cell for infection by a virus which binds to D1.

Inventors:: Freimuth, Paul I.

Issue Date:: 2010-04-06

Research Org.:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1176211

Patent Number(s):: 7691627

Application Number:: 11/581,689

Assignee:: Brookhaven Science Associates, LLC (Upton, NY)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K47/42 - Proteins

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K14/705 - Receptors
C07K2319/00 - Fusion polypeptide

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DOE Contract Number:: AC02-98CH10886

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats


                    Freimuth, Paul I. Nucleic acid sequences encoding D1 and D1/D2 domains of human coxsackievirus and adenovirus receptor (CAR).  United States: N. p., 2010. 
        Web.

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                    Freimuth, Paul I. Nucleic acid sequences encoding D1 and D1/D2 domains of human coxsackievirus and adenovirus receptor (CAR).  United States.

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                    Freimuth, Paul I. Tue .  
        "Nucleic acid sequences encoding D1 and D1/D2 domains of human coxsackievirus and adenovirus receptor (CAR)".  United States.  https://www.osti.gov/servlets/purl/1176211.

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@article{osti_1176211,

  title        = {Nucleic acid sequences encoding D1 and D1/D2 domains of human coxsackievirus and adenovirus receptor (CAR)},

  author       = {Freimuth, Paul I.},

  abstractNote = {The invention provides recombinant human CAR (coxsackievirus and adenovirus receptor) polypeptides which bind adenovirus. Specifically, polypeptides corresponding to adenovirus binding domain D1 and the entire extracellular domain of human CAR protein comprising D1 and D2 are provided. In another aspect, the invention provides nucleic acid sequences encoding these domains and expression vectors for producing the domains and bacterial cells containing such vectors. The invention also includes an isolated fusion protein comprised of the D1 polypeptide fused to a polypeptide which facilitates folding of D1 when expressed in bacteria. The functional D1 domain finds application in a therapeutic method for treating a patient infected with a CAR D1-binding virus, and also in a method for identifying an antiviral compound which interferes with viral attachment. The invention also provides a method for specifically targeting a cell for infection by a virus which binds to D1.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2010},

  month        = {4}

}

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Works referenced in this record:

From genes to protein structure and function: novel applications of computational approaches in the genomic era
journal, January 2000

Skolnick, Jeffrey; Fetrow, Jacquelyn S.
Trends in Biotechnology, Vol. 18, Issue 1, p. 34-39
https://doi.org/10.1016/S0167-7799(99)01398-0

Solution Structure of the Coxsackievirus and Adenovirus Receptor Domain 1 ^† ^, ^‡
journal, February 2004

Jiang, Shaokai; Jacobs, Amy; Laue, Thomas M.
Biochemistry, Vol. 43, Issue 7
https://doi.org/10.1021/bi035490x

A single locus on human chromosome 21 directs the expression of a receptor for adenovirus type 2 in mouse A9 cells.
journal, January 1997

Mayr, G. A.; Freimuth, P.
Journal of virology, Vol. 71, Issue 1
https://doi.org/10.1128/JVI.71.1.412-418.1997

Receptor for the group B coxsackieviruses and adenoviruses: CAR
journal, January 2001

Carson, Steven D.
Reviews in Medical Virology, Vol. 11, Issue 4
https://doi.org/10.1002/rmv.318

The Coxsackievirus and Adenovirus Receptor
book, January 2008

Freimuth, P.; Philipson, L.; Carson, S. D.
Current Topics in Microbiology and Immunology
https://doi.org/10.1007/978-3-540-75546-3_4

Human adenovirus-host cell interactions: comparative study with members of subgroups B and C.
journal, January 1990

Defer, C.; Belin, M. T.; Caillet-Boudin, M. L.
Journal of Virology, Vol. 64, Issue 8
https://doi.org/10.1128/JVI.64.8.3661-3673.1990

A human cell line selected for resistance to adenovirus infection has reduced levels of the virus receptor.
journal, January 1996

Freimuth, P.
Journal of virology, Vol. 70, Issue 6
https://doi.org/10.1128/JVI.70.6.4081-4085.1996

Powers and Pitfalls in Sequence Analysis: The 70% Hurdle
journal, April 2000

Bork, P.
Genome Research, Vol. 10, Issue 4, p. 398-400
https://doi.org/10.1101/gr.10.4.398

Crystal structure of the receptor-binding domain of adenovirus type 5 fiberprotein at 1.7 Å resolution
journal, December 1994

Xia, Di; Henry, Lynda J.; Gerard, Robert D.
Structure, Vol. 2, Issue 12
https://doi.org/10.1016/S0969-2126(94)00126-X

Recombinant protein expression in Escherichia coli
journal, October 1999

Baneyx, F.
Current Opinion in Biotechnology, Vol. 10, Issue 5
https://doi.org/10.1016/S0958-1669(99)00003-8

HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
journal, April 1997

Tomko, R. P.; Xu, R.; Philipson, L.
Proceedings of the National Academy of Sciences, Vol. 94, Issue 7
https://doi.org/10.1073/pnas.94.7.3352

The Immunoglobulin Fold Structural Classification, Sequence Patterns and Common Core
journal, September 1994

Bork, P.; Holm, L.; Sander, C.
Journal of Molecular Biology, Vol. 242, Issue 4
https://doi.org/10.1016/S0022-2836(84)71582-8

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Ngo, J. Thomas; Marks, Joe; Karplus, Martin
The Protein Folding Problem and Tertiary Structure Prediction, p. 433-506
https://doi.org/10.1007/978-1-4684-6831-1_14

Coxsackievirus and Adenovirus Receptor Amino-Terminal Immunoglobulin V-Related Domain Binds Adenovirus Type 2 and Fiber Knob from Adenovirus Type 12
journal, February 1999

Freimuth, Paul; Springer, Karen; Berard, Chris
Journal of Virology, Vol. 73, Issue 2
https://doi.org/10.1128/JVI.73.2.1392-1398.1999

Additivity of mutational effects in proteins
journal, September 1990

Wells, James A.
Biochemistry, Vol. 29, Issue 37, p. 8509-8517
https://doi.org/10.1021/bi00489a001

Protein annotation: detective work for function prediction
journal, June 1998

Doerks, T.
Trends in Genetics, Vol. 14, Issue 6
https://doi.org/10.1016/S0168-9525(98)01486-3

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
journal, February 1997

Bergelson, J. M.
Science, Vol. 275, Issue 5304
https://doi.org/10.1126/science.275.5304.1320

Unrelated animal viruses share receptors
journal, February 1976

Lonberg-Holm, K.; Crowell, R. L.; Philipson, L.
Nature, Vol. 259, Issue 5545
https://doi.org/10.1038/259679a0

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Similar Records

Title: Nucleic acid sequences encoding D1 and D1/D2 domains of human coxsackievirus and adenovirus receptor (CAR)

Abstract

Citation Formats

From genes to protein structure and function: novel applications of computational approaches in the genomic era journal, January 2000

Solution Structure of the Coxsackievirus and Adenovirus Receptor Domain 1 † , ‡ journal, February 2004

A single locus on human chromosome 21 directs the expression of a receptor for adenovirus type 2 in mouse A9 cells. journal, January 1997

Receptor for the group B coxsackieviruses and adenoviruses: CAR journal, January 2001

The Coxsackievirus and Adenovirus Receptor book, January 2008

Human adenovirus-host cell interactions: comparative study with members of subgroups B and C. journal, January 1990

A human cell line selected for resistance to adenovirus infection has reduced levels of the virus receptor. journal, January 1996

Powers and Pitfalls in Sequence Analysis: The 70% Hurdle journal, April 2000

Crystal structure of the receptor-binding domain of adenovirus type 5 fiberprotein at 1.7 Å resolution journal, December 1994

Recombinant protein expression in Escherichia coli journal, October 1999

HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses journal, April 1997

The Immunoglobulin Fold Structural Classification, Sequence Patterns and Common Core journal, September 1994

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox book, January 1994

Coxsackievirus and Adenovirus Receptor Amino-Terminal Immunoglobulin V-Related Domain Binds Adenovirus Type 2 and Fiber Knob from Adenovirus Type 12 journal, February 1999

Additivity of mutational effects in proteins journal, September 1990

Protein annotation: detective work for function prediction journal, June 1998

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5 journal, February 1997

Unrelated animal viruses share receptors journal, February 1976

From genes to protein structure and function: novel applications of computational approaches in the genomic era
journal, January 2000

Solution Structure of the Coxsackievirus and Adenovirus Receptor Domain 1 ^† ^, ^‡
journal, February 2004

A single locus on human chromosome 21 directs the expression of a receptor for adenovirus type 2 in mouse A9 cells.
journal, January 1997

Receptor for the group B coxsackieviruses and adenoviruses: CAR
journal, January 2001

The Coxsackievirus and Adenovirus Receptor
book, January 2008

Human adenovirus-host cell interactions: comparative study with members of subgroups B and C.
journal, January 1990

A human cell line selected for resistance to adenovirus infection has reduced levels of the virus receptor.
journal, January 1996

Powers and Pitfalls in Sequence Analysis: The 70% Hurdle
journal, April 2000

Crystal structure of the receptor-binding domain of adenovirus type 5 fiberprotein at 1.7 Å resolution
journal, December 1994

Recombinant protein expression in Escherichia coli
journal, October 1999

HCAR and MCAR: The human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
journal, April 1997

The Immunoglobulin Fold Structural Classification, Sequence Patterns and Common Core
journal, September 1994

Computational Complexity, Protein Structure Prediction, and the Levinthal Paradox
book, January 1994

Coxsackievirus and Adenovirus Receptor Amino-Terminal Immunoglobulin V-Related Domain Binds Adenovirus Type 2 and Fiber Knob from Adenovirus Type 12
journal, February 1999

Additivity of mutational effects in proteins
journal, September 1990

Protein annotation: detective work for function prediction
journal, June 1998

Isolation of a Common Receptor for Coxsackie B Viruses and Adenoviruses 2 and 5
journal, February 1997

Unrelated animal viruses share receptors
journal, February 1976