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Title: Method of identifying hairpin DNA probes by partial fold analysis

Abstract

Methods of identifying molecular beacons in which a secondary structure prediction algorithm is employed to identify oligonucleotide sequences within a target gene having the requisite hairpin structure. Isolated oligonucleotides, molecular beacons prepared from those oligonucleotides, and their use are also disclosed.

Inventors:
;
Issue Date:
Research Org.:
University Of Rochester, Rochester, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176186
Patent Number(s):
7442510
Application Number:
11/553,904
Assignee:
University Of Rochester
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
DOE Contract Number:  
FG02-02ER63410
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES

Citation Formats

Miller, Benjamin L., and Strohsahl, Christopher M. Method of identifying hairpin DNA probes by partial fold analysis. United States: N. p., 2008. Web.
Miller, Benjamin L., & Strohsahl, Christopher M. Method of identifying hairpin DNA probes by partial fold analysis. United States.
Miller, Benjamin L., and Strohsahl, Christopher M. Tue . "Method of identifying hairpin DNA probes by partial fold analysis". United States. https://www.osti.gov/servlets/purl/1176186.
@article{osti_1176186,
title = {Method of identifying hairpin DNA probes by partial fold analysis},
author = {Miller, Benjamin L. and Strohsahl, Christopher M.},
abstractNote = {Methods of identifying molecular beacons in which a secondary structure prediction algorithm is employed to identify oligonucleotide sequences within a target gene having the requisite hairpin structure. Isolated oligonucleotides, molecular beacons prepared from those oligonucleotides, and their use are also disclosed.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2008},
month = {10}
}

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Works referenced in this record:

Effect of Secondary Structure on the Thermodynamics and Kinetics of PNA Hybridization to DNA Hairpins
journal, November 2001


Hybridization-Based Unquenching of DNA Hairpins on Au Surfaces:  Prototypical “Molecular Beacon” Biosensors
journal, April 2003


Rapid Identification of Candida dubliniensis Using a Species-Specific Molecular Beacon
journal, January 2000


Stem-loop oligonucleotides: a robust tool for molecular biology and biotechnology
journal, June 2002


Thermodynamic basis of the enhanced specificity of structured DNA probes
journal, May 1999


Single-mismatch detection using gold-quenched fluorescent oligonucleotides
journal, April 2001