Title: Water-soluble luminescent quantum dots and biomolecular conjugates thereof and related compositions and methods of use

Abstract

The present invention provides a water-soluble luminescent quantum dot, a biomolecular conjugate thereof and a composition comprising such a quantum dot or conjugate. Additionally, the present invention provides a method of obtaining a luminescent quantum dot, a method of making a biomolecular conjugate thereof, and methods of using a biomolecular conjugate for ultrasensitive nonisotopic detection in vitro and in vivo.

Inventors:

Nie, Shuming; Chan, Warren C. W.; Emory, Stephen

Issue Date:

2007-03-20

Research Org.:

Indiana Univ., Bloomington, IN (United States)

Sponsoring Org.:

USDOE; National Science Foundation (NSF)

OSTI Identifier:

1176155

Patent Number(s):

7192785

Application Number:

10/228,716

Assignee:

Indiana University Research and Technology Corporation (Indianapolis, IN)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

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B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES

B82Y15/00 - Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
B82Y30/00 - Nanotechnology for materials or surface science, e.g. nanocomposites
B82Y5/00 - Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

C12Q1/6816 - characterised by the detection means
C12Q1/6818 - involving interaction of two or more labels, e.g. resonant energy transfer
C12Q1/6834 - Enzymatic or biochemical coupling of nucleic acids to a solid phase
C12Q2565/1015 - labels being on the same oligonucleotide

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N33/588 - {with semiconductor nanocrystal label, e.g. quantum dots}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

Y10T428/2982 - Particulate matter [e.g., sphere, flake, etc.]
Y10T428/2991 - Coated

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DOE Contract Number:  

FG02-98ER24873; CHE-9610254

Resource Type:

Patent

Resource Relation:

Patent File Date: 2002 Aug 27

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES; 47 OTHER INSTRUMENTATION