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Title: Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders

Abstract

Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and identification of tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.

Inventors:
Issue Date:
Research Org.:
Arch Development Corporation, Chicago, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1176153
Patent Number(s):
7192711
Application Number:
11/087,072
Assignee:
Arch Development Corporation (Chicago, IL)
Patent Classifications (CPCs):
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
DOE Contract Number:  
FG02-86ER60408
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Olopade, Olufunmilayo I. Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders. United States: N. p., 2007. Web.
Olopade, Olufunmilayo I. Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders. United States.
Olopade, Olufunmilayo I. Tue . "Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders". United States. https://www.osti.gov/servlets/purl/1176153.
@article{osti_1176153,
title = {Compositions and methods involving methyladenosine phosphorylase in the diagnosis and treatment of proliferative disorders},
author = {Olopade, Olufunmilayo I.},
abstractNote = {Disclosed are novel nucleic acid and peptide compositions comprising methylthioadenosine phosphorylase (MTAP) and methods of use for MTAP amino acid sequences and DNA segments comprising MTAP in the diagnosis of human cancers and development of MTAP-specific antibodies. Also disclosed are methods for the diagnosis and treatment of tumors and other proliferative cell disorders, and identification of tumor suppressor genes and gene products from the human 9p21-p22 chromosome region. Such methods are useful in the diagnosis of multiple tumor types such as bladder cancer, lung cancer, breast cancer, pancreatic cancer, brain tumors, lymphomas, gliomas, melanomas, and leukemias.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2007},
month = {3}
}

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Works referenced in this record:

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